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| | POLI | DNA polymerase iota. (702 aa) |
| | MDC1 | Mediator of DNA damage checkpoint 1. (1912 aa) |
| | GTF2H4 | General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (463 aa) |
| | UBE2B | Ubiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | EP300 | E1A binding protein p300. (2308 aa) |
| | FANCE | FA complementation group E. (539 aa) |
| | RMI1 | RecQ mediated genome instability 1. (634 aa) |
| | POT1 | Protection of telomeres 1. (785 aa) |
| | POLH | DNA polymerase eta. (712 aa) |
| | VCP | Valosin containing protein; Belongs to the AAA ATPase family. (806 aa) |
| | FANCG | FA complementation group G. (806 aa) |
| | POLR2B | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1325 aa) |
| | XPA | XPA, DNA damage recognition and repair factor. (273 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | RPS9 | TCF3 fusion partner. (253 aa) |
| | RAD23B | RAD23 homolog B, nucleotide excision repair protein. (406 aa) |
| | LOC100685589 | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (418 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (519 aa) |
| | POLD1 | DNA polymerase. (1107 aa) |
| | CLSPN | Claspin. (1339 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (908 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (314 aa) |
| | XPC | XPC complex subunit, DNA damage recognition and repair factor. (949 aa) |
| | ERCC3 | ERCC excision repair 3, TFIIH core complex helicase subunit. (779 aa) |
| | SUMO2 | Small ubiquitin-related modifier. (95 aa) |
| | MLH1 | MutL homolog 1. (757 aa) |
| | MBD4 | Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (572 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (279 aa) |
| | PAXIP1 | PAX interacting protein 1. (1035 aa) |
| | WDR48 | WD repeat domain 48. (677 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) |
| | RAD18 | RAD18 E3 ubiquitin protein ligase. (503 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2549 aa) |
| | FAAP100 | FA core complex associated protein 100. (918 aa) |
| | NPLOC4 | NPL4 homolog, ubiquitin recognition factor. (615 aa) |
| | GPS1 | G protein pathway suppressor 1. (449 aa) |
| | ERCC5 | Uncharacterized protein. (1627 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (421 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | CUL4A | Cullin 4A; Belongs to the cullin family. (761 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3446 aa) |
| | PPP4R2 | Protein phosphatase 4 regulatory subunit 2. (416 aa) |
| | HPX | Amyloid beta precursor protein binding family B member 1. (664 aa) |
| | WRN | WRN RecQ like helicase. (1574 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1513 aa) |
| | POLR2I | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1486 aa) |
| | PARG | Poly(ADP-ribose) glycohydrolase. (976 aa) |
| | COPS5 | COP9 signalosome subunit 5. (334 aa) |
| | TDG | Thymine DNA glycosylase. (406 aa) |
| | SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa) |
| | CDK7 | Cyclin dependent kinase 7. (346 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (680 aa) |
| | GTF2H2 | General transcription factor IIH subunit. (395 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | NEIL2 | Nei like DNA glycosylase 2. (373 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (431 aa) |
| | ACTR8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa) |
| | AQR | RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. (1418 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (427 aa) |
| | INO80B | PAPA-1 domain-containing protein. (356 aa) |
| | POLR2C | RNA polymerase II subunit C. (280 aa) |
| | MSH3 | MutS homolog 3; Component of the post-replicative DNA mismatch repair system (MMR). (1058 aa) |
| | DDB2 | Damage specific DNA binding protein 2. (427 aa) |
| | ACTR5 | Actin related protein 5; Belongs to the actin family. (615 aa) |
| | COPS4 | COP9 signalosome subunit 4. (406 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (543 aa) |
| | GTF2H1 | General transcription factor IIH subunit 1. (548 aa) |
| | DCLRE1B | DNA cross-link repair 1B. (530 aa) |
| | POLK | DNA polymerase kappa. (861 aa) |
| | INO80 | INO80 complex ATPase subunit. (1560 aa) |
| | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4929 aa) |
| | RFC5 | Replication factor C subunit 5. (339 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (625 aa) |
| | HMGN1 | High mobility group nucleosome binding domain 1. (101 aa) |
| | NFRKB | Nuclear factor related to kappaB binding protein. (1311 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1029 aa) |
| | TDP2 | Tyrosyl-DNA phosphodiesterase 2. (330 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | CHEK1 | Checkpoint kinase 1. (454 aa) |
| | CHD1L | Chromodomain helicase DNA binding protein 1 like. (883 aa) |
| | DCLRE1A | DNA cross-link repair 1A. (1049 aa) |
| | UBA7 | Ubiquitin like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family. (1008 aa) |
| | ACTL6A | Actin like 6A; Belongs to the actin family. (453 aa) |
| | KPNA2 | Importin subunit alpha; Functions in nuclear protein import. (529 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (390 aa) |
| | CLCF1 | Cardiotrophin like cytokine factor 1. (261 aa) |
| | SPRTN | SprT-like N-terminal domain. (487 aa) |
| | FANCB | FA complementation group B. (850 aa) |
| | EYA3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa) |
| | DTL | Denticleless E3 ubiquitin protein ligase homolog. (730 aa) |
| | BLM | BLM RecQ like helicase. (1420 aa) |
| | ATRIP | ATR interacting protein. (792 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1936 aa) |
| | H2AJ | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | LOC486670 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (551 aa) |
| | INO80D | INO80 complex subunit D. (1029 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1017 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (737 aa) |
| | COPS7A | COP9 signalosome subunit 7A. (275 aa) |
| | UBA52 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa) |
| | COPS6 | COP9 signalosome subunit 6. (321 aa) |
| | ACTG1 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (353 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (336 aa) |
| | POLR2G | RNA polymerase II subunit G. (172 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (255 aa) |
| | EXO1 | Exonuclease 1. (836 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (405 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (972 aa) |
| | DDB1 | Damage specific DNA binding protein 1. (1140 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (720 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (196 aa) |
| | RNF111 | Ring finger protein 111. (1002 aa) |
| | INO80E | INO80 complex subunit E. (244 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (307 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (272 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (286 aa) |
| | TRIM25 | Tripartite motif containing 25. (631 aa) |
| | RAD51C | RAD51 paralog C. (379 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1243 aa) |
| | INO80C | INO80 complex subunit C. (192 aa) |
| | YY1 | YY1 transcription factor. (410 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (909 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (989 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (349 aa) |
| | ALKBH5 | AlkB homolog 5, RNA demethylase. (394 aa) |
| | ZNF830 | Zinc finger protein 830. (371 aa) |
| | COPS3 | COP9 signalosome subunit 3. (423 aa) |
| | USP1 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (785 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (281 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (902 aa) |
| | RMI2 | RecQ mediated genome instability 2. (156 aa) |
| | USP7 | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1086 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (521 aa) |
| | CETN2 | Uncharacterized protein. (172 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1754 aa) |
| | ISG15 | ISG15 ubiquitin like modifier. (168 aa) |
| | NTHL1 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (336 aa) |
| | POLR2E | RNA polymerase II subunit E. (253 aa) |
| | MPG | N-methylpurine DNA glycosylase. (266 aa) |
| | FANCA | FA complementation group A. (1448 aa) |
| | ABL1 | Tyrosine-protein kinase. (1150 aa) |
| | USP10 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (850 aa) |
| | TERF2IP | TERF2 interacting protein. (403 aa) |
| | BAP1 | Ubiquitin carboxyl-terminal hydrolase. (729 aa) |
| | CCNH | Cyclin H; Belongs to the cyclin family. (325 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (156 aa) |
| | ACD | ACD shelterin complex subunit and telomerase recruitment factor. (455 aa) |
| | H2AX | Histone H2A; Belongs to the histone H2A family. (143 aa) |
| | LOC482202 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC102152481 | Uncharacterized protein. (403 aa) |
| | POLR2J | RNA polymerase II subunit J. (185 aa) |
| | TINF2 | TERF1 interacting nuclear factor 2. (452 aa) |
| | POLN | DNA polymerase nu. (899 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | ADPRHL2 | ADP-ribosylhydrolase like 2. (520 aa) |
| | SMUG1 | Single-strand-selective monofunctional uracil-DNA glycosylase 1. (299 aa) |
| | RNF4 | Ring finger protein 4. (190 aa) |
| | GTF2H5 | General transcription factor IIH subunit 5. (71 aa) |
| | LOC478743 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1344 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1355 aa) |
| | UBXN1 | UBX domain protein 1. (308 aa) |
| | POLR2A | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1789 aa) |
| | UBE2I | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (192 aa) |
| | NBN | Nibrin. (886 aa) |
| | J9NWQ8_CANLF | Histone H2A; Belongs to the histone H2A family. (96 aa) |
| | UBE2V2 | Ubiquitin conjugating enzyme E2 V2. (145 aa) |
| | USP43 | Ubiquitin specific peptidase 43; Belongs to the peptidase C19 family. (1121 aa) |
| | COPS8 | PCI domain-containing protein. (209 aa) |
| | UFD1 | Ubiquitin recognition factor in ER associated degradation 1. (307 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (829 aa) |
| | RCHY1 | Ring finger and CHY zinc finger domain containing 1. (259 aa) |
| | SIRT6 | Sirtuin 6. (403 aa) |
| | H2BC21 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | J9P0B2_CANLF | Histone domain-containing protein; Belongs to the histone H2B family. (277 aa) |
| | LOC483168 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | NHEJ1 | Non-homologous end joining factor 1. (299 aa) |
| | LOC611231 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | H2BC18 | Histone H2B; Belongs to the histone H2B family. (135 aa) |
| | FANCD2 | FA complementation group D2. (1471 aa) |
| | PCLAF | PAF domain-containing protein. (160 aa) |
| | FANCF | FA complementation group F. (494 aa) |
| | FAAP20 | FANCA_interact domain-containing protein. (196 aa) |
| | RAD50 | RAD50 double strand break repair protein. (1312 aa) |
| | MCRS1 | Microspherule protein 1. (518 aa) |
| | UBE2N-2 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | LOC488289 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1275 aa) |
| | H2AC6 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | USP45 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (739 aa) |
| | LOC488290 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | FANCM | FA complementation group M. (2047 aa) |
| | PPIE | Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (328 aa) |
| | NEIL3 | Nei like DNA glycosylase 3. (604 aa) |
| | APEX1 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (460 aa) |
| | XAB2 | XPA binding protein 2. (881 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (941 aa) |
| | BAZ1B | Bromodomain adjacent to zinc finger domain 1B. (1483 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | FANCC | FA complementation group C. (749 aa) |
| | ENSCAFP00000043968 | RPOL4c domain-containing protein. (108 aa) |
| | FANCL | FA complementation group L. (412 aa) |
| | PRPF19 | Pre-mRNA processing factor 19. (522 aa) |
| | LOC488264 | Histone H2B; Belongs to the histone H2B family. (435 aa) |
| | ENSCAFP00000046288 | Histone H2B; Belongs to the histone H2B family. (177 aa) |
| | ENSCAFP00000046717 | MPN domain-containing protein. (239 aa) |
| | POLE4 | CBFD_NFYB_HMF domain-containing protein. (275 aa) |
| | UBE2L6 | Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family. (190 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | COPS2 | COP9 signalosome subunit 2. (462 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (637 aa) |
| | TIMELESS | Timeless circadian regulator. (1297 aa) |
| | ENSCAFP00000049773 | Uncharacterized protein. (64 aa) |
| | TERF2 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (540 aa) |
| | ENSCAFP00000050780 | Ubiquitin-like domain-containing protein. (151 aa) |
| | RFC2 | Replication factor C subunit 2. (367 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3121 aa) |
| | POLE2 | DNA polymerase epsilon 2, accessory subunit. (640 aa) |
| | H2BC10 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | POLR2H | RNA polymerase II subunit H. (122 aa) |
| | RBX1 | Ring-box 1. (108 aa) |
| | KDM4B | Lysine demethylase 4B. (1218 aa) |
| | OGG1 | 8-oxoguanine DNA glycosylase. (344 aa) |
| | TCEA1 | Transcription elongation factor A1. (484 aa) |
| | AFF3 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1346 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (736 aa) |
| | CUL4B | Cullin 4B; Belongs to the cullin family. (1019 aa) |
| | RNF168 | Ring finger protein 168. (585 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (388 aa) |
| | PIAS3 | Protein inhibitor of activated STAT 3. (849 aa) |
| | POLR2F | RNA polymerase II subunit F. (167 aa) |
| | TDP1 | Tyrosyl-DNA phosphodiesterase 1. (639 aa) |
| | RAD23A | RAD23 homolog A, nucleotide excision repair protein. (528 aa) |
| | MUTYH | MutY DNA glycosylase. (729 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2335 aa) |
| | RPA3 | Uncharacterized protein. (351 aa) |
| | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (438 aa) |
| | RAD51B | RAD51 paralog B. (350 aa) |
| | DCLRE1C | DNA cross-link repair 1C. (715 aa) |
| | FANCI | FA complementation group I. (1404 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (612 aa) |
| | MNAT1 | MNAT1 component of CDK activating kinase. (358 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (187 aa) |
| | RAD51 | DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Part of a PALB2-scaffolded HR [...] (317 aa) |
| | PARP2 | Poly [ADP-ribose] polymerase. (602 aa) |
| | LIG3 | DNA ligase. (991 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (585 aa) |
| | UVSSA | UV stimulated scaffold protein A. (719 aa) |
| | KDM4A | Lysine demethylase 4A. (1066 aa) |
| | PPP5C | Serine/threonine-protein phosphatase. (468 aa) |
| | PNKP | Polynucleotide kinase 3'-phosphatase. (589 aa) |
| | POLD3 | DNA polymerase delta 3, accessory subunit. (541 aa) |
| | RPA2 | Replication protein A2. (390 aa) |
| | PMS2 | PMS1 homolog 2, mismatch repair system component. (1571 aa) |
| | ERCC2 | ERCC excision repair 2, TFIIH core complex helicase subunit. (764 aa) |
| | COPS7B | COP9 signalosome subunit 7B. (275 aa) |
| | RFC1 | Replication factor C subunit 1. (1198 aa) |
| | ISY1 | Uncharacterized protein. (402 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (578 aa) |
| | XRCC1 | Uncharacterized protein. (664 aa) |
| | GTF2H3 | General transcription factor IIH subunit 3. (308 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (579 aa) |
| | PIAS1 | Protein inhibitor of activated STAT 1. (655 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (341 aa) |
| | UNG | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (298 aa) |
| | HUS1 | HUS1 checkpoint clamp component. (420 aa) |
| | NEIL1 | Nei like DNA glycosylase 1. (519 aa) |
| | FAAP24 | FA core complex associated protein 24. (253 aa) |
| | LIG1 | DNA ligase. (915 aa) |
