(5 nodes) MET activates PI3K/AKT signaling network (Canis lupus familiaris)

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Your Input:
	GAB1	GRB2 associated binding protein 1. (701 aa)
	HGF	Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	GRB2	Growth factor receptor bound protein 2. (250 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GAB1	GRB2	ENSCAFP00000005384	ENSCAFP00000049390	GRB2 associated binding protein 1.	Growth factor receptor bound protein 2.	0.998
GAB1	HGF	ENSCAFP00000005384	ENSCAFP00000009539	GRB2 associated binding protein 1.	Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily.	0.662
GAB1	PIK3CA	ENSCAFP00000005384	ENSCAFP00000048355	GRB2 associated binding protein 1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.913
GAB1	PIK3R1	ENSCAFP00000005384	ENSCAFP00000011322	GRB2 associated binding protein 1.	Phosphoinositide-3-kinase regulatory subunit 1.	0.978
GRB2	GAB1	ENSCAFP00000049390	ENSCAFP00000005384	Growth factor receptor bound protein 2.	GRB2 associated binding protein 1.	0.998
GRB2	HGF	ENSCAFP00000049390	ENSCAFP00000009539	Growth factor receptor bound protein 2.	Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily.	0.640
GRB2	PIK3CA	ENSCAFP00000049390	ENSCAFP00000048355	Growth factor receptor bound protein 2.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.689
GRB2	PIK3R1	ENSCAFP00000049390	ENSCAFP00000011322	Growth factor receptor bound protein 2.	Phosphoinositide-3-kinase regulatory subunit 1.	0.948
HGF	GAB1	ENSCAFP00000009539	ENSCAFP00000005384	Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily.	GRB2 associated binding protein 1.	0.662
HGF	GRB2	ENSCAFP00000009539	ENSCAFP00000049390	Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily.	Growth factor receptor bound protein 2.	0.640
HGF	PIK3CA	ENSCAFP00000009539	ENSCAFP00000048355	Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.568
HGF	PIK3R1	ENSCAFP00000009539	ENSCAFP00000011322	Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.505
PIK3CA	GAB1	ENSCAFP00000048355	ENSCAFP00000005384	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	GRB2 associated binding protein 1.	0.913
PIK3CA	GRB2	ENSCAFP00000048355	ENSCAFP00000049390	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Growth factor receptor bound protein 2.	0.689
PIK3CA	HGF	ENSCAFP00000048355	ENSCAFP00000009539	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily.	0.568
PIK3CA	PIK3R1	ENSCAFP00000048355	ENSCAFP00000011322	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Phosphoinositide-3-kinase regulatory subunit 1.	0.999
PIK3R1	GAB1	ENSCAFP00000011322	ENSCAFP00000005384	Phosphoinositide-3-kinase regulatory subunit 1.	GRB2 associated binding protein 1.	0.978
PIK3R1	GRB2	ENSCAFP00000011322	ENSCAFP00000049390	Phosphoinositide-3-kinase regulatory subunit 1.	Growth factor receptor bound protein 2.	0.948
PIK3R1	HGF	ENSCAFP00000011322	ENSCAFP00000009539	Phosphoinositide-3-kinase regulatory subunit 1.	Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily.	0.505
PIK3R1	PIK3CA	ENSCAFP00000011322	ENSCAFP00000048355	Phosphoinositide-3-kinase regulatory subunit 1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.999