5 items (Canis lupus familiaris) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	TCF7L1	Transcription factor 7 like 1. (588 aa)
	RUNX3	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (408 aa)
	TCF7L2	Transcription factor 7 like 2. (565 aa)
	TCF7	Transcription factor 7. (484 aa)
	LEF1	Lymphoid enhancer binding factor 1. (481 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LEF1	RUNX3	ENSCAFP00000056485	ENSCAFP00000019008	Lymphoid enhancer binding factor 1.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.627
LEF1	TCF7	ENSCAFP00000056485	ENSCAFP00000043629	Lymphoid enhancer binding factor 1.	Transcription factor 7.	0.664
LEF1	TCF7L1	ENSCAFP00000056485	ENSCAFP00000011603	Lymphoid enhancer binding factor 1.	Transcription factor 7 like 1.	0.527
LEF1	TCF7L2	ENSCAFP00000056485	ENSCAFP00000039879	Lymphoid enhancer binding factor 1.	Transcription factor 7 like 2.	0.842
RUNX3	LEF1	ENSCAFP00000019008	ENSCAFP00000056485	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	Lymphoid enhancer binding factor 1.	0.627
RUNX3	TCF7	ENSCAFP00000019008	ENSCAFP00000043629	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	Transcription factor 7.	0.598
RUNX3	TCF7L1	ENSCAFP00000019008	ENSCAFP00000011603	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	Transcription factor 7 like 1.	0.579
RUNX3	TCF7L2	ENSCAFP00000019008	ENSCAFP00000039879	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	Transcription factor 7 like 2.	0.584
TCF7	LEF1	ENSCAFP00000043629	ENSCAFP00000056485	Transcription factor 7.	Lymphoid enhancer binding factor 1.	0.664
TCF7	RUNX3	ENSCAFP00000043629	ENSCAFP00000019008	Transcription factor 7.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.598
TCF7	TCF7L1	ENSCAFP00000043629	ENSCAFP00000011603	Transcription factor 7.	Transcription factor 7 like 1.	0.910
TCF7	TCF7L2	ENSCAFP00000043629	ENSCAFP00000039879	Transcription factor 7.	Transcription factor 7 like 2.	0.916
TCF7L1	LEF1	ENSCAFP00000011603	ENSCAFP00000056485	Transcription factor 7 like 1.	Lymphoid enhancer binding factor 1.	0.527
TCF7L1	RUNX3	ENSCAFP00000011603	ENSCAFP00000019008	Transcription factor 7 like 1.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.579
TCF7L1	TCF7	ENSCAFP00000011603	ENSCAFP00000043629	Transcription factor 7 like 1.	Transcription factor 7.	0.910
TCF7L1	TCF7L2	ENSCAFP00000011603	ENSCAFP00000039879	Transcription factor 7 like 1.	Transcription factor 7 like 2.	0.920
TCF7L2	LEF1	ENSCAFP00000039879	ENSCAFP00000056485	Transcription factor 7 like 2.	Lymphoid enhancer binding factor 1.	0.842
TCF7L2	RUNX3	ENSCAFP00000039879	ENSCAFP00000019008	Transcription factor 7 like 2.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.584
TCF7L2	TCF7	ENSCAFP00000039879	ENSCAFP00000043629	Transcription factor 7 like 2.	Transcription factor 7.	0.916
TCF7L2	TCF7L1	ENSCAFP00000039879	ENSCAFP00000011603	Transcription factor 7 like 2.	Transcription factor 7 like 1.	0.920