(82 nodes) RAC2 GTPase cycle network (Canis lupus familiaris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LMAN1	Lectin, mannose binding 1. (518 aa)
	SAMM50	SAMM50 sorting and assembly machinery component. (476 aa)
	DEF6	DEF6 guanine nucleotide exchange factor. (631 aa)
	CDC42EP1	CDC42 effector protein 1. (326 aa)
	RAC2	Rac family small GTPase 2. (192 aa)
	NCF4	Neutrophil cytosolic factor 4. (339 aa)
	ARHGAP39	Rho GTPase activating protein 39. (1050 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (820 aa)
	PIK3R3	Uncharacterized protein. (461 aa)
	ABI1	Abl interactor 1. (508 aa)
	BRK1	BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
	SLITRK5	SLIT and NTRK like family member 5. (958 aa)
	LAMTOR1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
	ANKLE2	Ankyrin repeat and LEM domain containing 2. (959 aa)
	NCKAP1L	NCK associated protein 1 like. (1133 aa)
	KIAA0355	KIAA0355. (1041 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
	RBM39	RNA binding motif protein 39. (530 aa)
	STBD1	Starch binding domain 1. (303 aa)
	ARHGAP1	Cdc42 GTPase-activating protein. (439 aa)
	TRIO	Trio Rho guanine nucleotide exchange factor. (3053 aa)
	CYFIP1	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1213 aa)
	TAOK3	TAO kinase 3. (898 aa)
	DOCK3	Dedicator of cytokinesis 3; Belongs to the DOCK family. (2030 aa)
	GIT2	GIT ArfGAP 2. (759 aa)
	VAPB	VAMP associated protein B and C. (243 aa)
	WASF2	WASP family member 2. (498 aa)
	IQGAP1	IQ motif containing GTPase activating protein 1. (1657 aa)
	DOCK1	Dedicator of cytokinesis 1; Belongs to the DOCK family. (1896 aa)
	NCKAP1	NCK associated protein 1. (1102 aa)
	PIK3R2	Uncharacterized protein. (726 aa)
	PLD2	Phospholipase. (837 aa)
	EPHA2	EPH receptor A2. (1121 aa)
	SYDE1	Synapse defective Rho GTPase homolog 1. (735 aa)
	LBR	Lamin B receptor. (618 aa)
	OPHN1	Oligophrenin 1. (802 aa)
	DOCK2	Dedicator of cytokinesis 2; Belongs to the DOCK family. (1830 aa)
	ARHGAP17	Rho GTPase activating protein 17. (918 aa)
	ARMCX3	Armadillo repeat containing X-linked 3. (379 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (845 aa)
	GIT1	GIT ArfGAP 1. (770 aa)
	MCF2	MCF.2 cell line derived transforming sequence. (1058 aa)
	VANGL1	Vang-like protein. (524 aa)
	PGRMC2	Progesterone receptor membrane component 2; Belongs to the cytochrome b5 family. (247 aa)
	PREX1	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1585 aa)
	DIAPH3	Diaphanous related formin 3. (1191 aa)
	ARHGAP35	Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase- activating protein [...] (1516 aa)
	EMD	Emerin. (260 aa)
	RACGAP1	Rac GTPase activating protein 1. (632 aa)
	VRK2	VRK serine/threonine kinase 2. (490 aa)
	SWAP70	Switching B cell complex subunit SWAP70. (590 aa)
	RAB7A	Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] (228 aa)
	PAK1	Non-specific serine/threonine protein kinase. (552 aa)
	ABR	ABR activator of RhoGEF and GTPase. (871 aa)
	MCAM	Melanoma cell adhesion molecule. (723 aa)
	NHS	NHS actin remodeling regulator. (1628 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	MTX1	Metaxin 1. (499 aa)
	BAIAP2L1	BAI1 associated protein 2 like 1. (530 aa)
	ELOVL7	DEP domain containing 1B. (725 aa)
	MPP7	Membrane palmitoylated protein 7; Belongs to the MAGUK family. (618 aa)
	ABI2	Abl interactor 2. (582 aa)
	DOCK10	Dedicator of cytokinesis 10; Belongs to the DOCK family. (2206 aa)
	CYBA	Cytochrome b-245 alpha chain. (336 aa)
	ARHGAP32	Rho GTPase activating protein 32. (2113 aa)
	NCF2	Neutrophil cytosolic factor 2. (535 aa)
	ARHGAP42	Rho GTPase activating protein 42. (837 aa)
	ARHGAP26	Rho GTPase activating protein 26. (936 aa)
	PAK4	Non-specific serine/threonine protein kinase. (656 aa)
	CDC42-2	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (191 aa)
	ARHGAP21	Rho GTPase activating protein 21. (1940 aa)
	TIAM1	T cell lymphoma invasion and metastasis 1. (1601 aa)
	ESYT1	Extended synaptotagmin 1. (1049 aa)
	VAV2	Vav guanine nucleotide exchange factor 2. (821 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1262 aa)
	ERBIN	Erbb2 interacting protein. (1460 aa)
	VAMP3	Vesicle associated membrane protein 3. (145 aa)
	VAV3	Vav guanine nucleotide exchange factor 3. (859 aa)
	DOCK4	Dedicator of cytokinesis 4; Belongs to the DOCK family. (1974 aa)
	PAK2	Non-specific serine/threonine protein kinase. (718 aa)
	ARHGDIA	Rho GDP dissociation inhibitor alpha. (281 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABI1	ABI2	ENSCAFP00000006495	ENSCAFP00000051949	Abl interactor 1.	Abl interactor 2.	0.564
ABI1	BAIAP2L1	ENSCAFP00000006495	ENSCAFP00000050716	Abl interactor 1.	BAI1 associated protein 2 like 1.	0.557
ABI1	BRK1	ENSCAFP00000006495	ENSCAFP00000007693	Abl interactor 1.	BRICK1 subunit of SCAR/WAVE actin nucleating complex.	0.971
ABI1	CAV1	ENSCAFP00000006495	ENSCAFP00000005060	Abl interactor 1.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.400
ABI1	CDC42-2	ENSCAFP00000006495	ENSCAFP00000060180	Abl interactor 1.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	0.456
ABI1	CDC42EP1	ENSCAFP00000006495	ENSCAFP00000002160	Abl interactor 1.	CDC42 effector protein 1.	0.400
ABI1	CYFIP1	ENSCAFP00000006495	ENSCAFP00000014294	Abl interactor 1.	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	0.966
ABI1	DIAPH3	ENSCAFP00000006495	ENSCAFP00000036887	Abl interactor 1.	Diaphanous related formin 3.	0.491
ABI1	DOCK1	ENSCAFP00000006495	ENSCAFP00000019326	Abl interactor 1.	Dedicator of cytokinesis 1; Belongs to the DOCK family.	0.602
ABI1	ELOVL7	ENSCAFP00000006495	ENSCAFP00000051437	Abl interactor 1.	DEP domain containing 1B.	0.416
ABI1	EPHA2	ENSCAFP00000006495	ENSCAFP00000023602	Abl interactor 1.	EPH receptor A2.	0.638
ABI1	ERBIN	ENSCAFP00000006495	ENSCAFP00000064102	Abl interactor 1.	Erbb2 interacting protein.	0.424
ABI1	GIT1	ENSCAFP00000006495	ENSCAFP00000027951	Abl interactor 1.	GIT ArfGAP 1.	0.446
ABI1	GIT2	ENSCAFP00000006495	ENSCAFP00000015836	Abl interactor 1.	GIT ArfGAP 2.	0.473
ABI1	IQGAP1	ENSCAFP00000006495	ENSCAFP00000018867	Abl interactor 1.	IQ motif containing GTPase activating protein 1.	0.485
ABI1	ITGB1	ENSCAFP00000006495	ENSCAFP00000005722	Abl interactor 1.	Integrin beta; Belongs to the integrin beta chain family.	0.405
ABI1	KIAA0355	ENSCAFP00000006495	ENSCAFP00000010894	Abl interactor 1.	KIAA0355.	0.438
ABI1	LAMTOR1	ENSCAFP00000006495	ENSCAFP00000008656	Abl interactor 1.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	0.400
ABI1	MCAM	ENSCAFP00000006495	ENSCAFP00000045607	Abl interactor 1.	Melanoma cell adhesion molecule.	0.400
ABI1	MPP7	ENSCAFP00000006495	ENSCAFP00000051915	Abl interactor 1.	Membrane palmitoylated protein 7; Belongs to the MAGUK family.	0.409