STRINGSTRING
LMAN1 LMAN1 ARHGAP39 ARHGAP39 HINT2 HINT2 CAV1 CAV1 ARHGAP12 ARHGAP12 SLC4A7 SLC4A7 PAK5 PAK5 DIAPH1 DIAPH1 PIK3R1 PIK3R1 RBM39 RBM39 STBD1 STBD1 PAK6 PAK6 ARHGAP1 ARHGAP1 ADD3 ADD3 RHOD RHOD MOSPD2 MOSPD2 VAPB VAPB PLXNB1 PLXNB1 WHAMM WHAMM PIK3R2 PIK3R2 ANKFY1 ANKFY1 LBR LBR ARHGAP17 ARHGAP17 GOLGA2 GOLGA2 VANGL1 VANGL1 PGRMC2 PGRMC2 DIAPH3 DIAPH3 ARHGAP35 ARHGAP35 EMD EMD TOR1AIP1 TOR1AIP1 RACGAP1 RACGAP1 VRK2 VRK2 RAB7A RAB7A MCAM MCAM ARHGAP5 ARHGAP5 STEAP3 STEAP3 ACTN1 ACTN1 CPNE8 CPNE8 ELOVL7 ELOVL7 AKAP12 AKAP12 ARHGAP32 ARHGAP32 LMNB1 LMNB1 FILIP1 FILIP1 DIAPH2 DIAPH2 CHCHD6 CHCHD6 ARHGAP26 ARHGAP26 ARHGAP21 ARHGAP21 ESYT1 ESYT1 VAMP3 VAMP3 CAPZB CAPZB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LMAN1Lectin, mannose binding 1. (518 aa)
ARHGAP39Rho GTPase activating protein 39. (1050 aa)
HINT2Histidine triad nucleotide binding protein 2. (163 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ARHGAP12Rho GTPase activating protein 12. (897 aa)
SLC4A7Anion exchange protein. (1212 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
DIAPH1Diaphanous related formin 1. (1283 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
RBM39RNA binding motif protein 39. (530 aa)
STBD1Starch binding domain 1. (303 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
ARHGAP1Cdc42 GTPase-activating protein. (439 aa)
ADD3Adducin 3. (706 aa)
RHODRas homolog family member D. (210 aa)
MOSPD2Motile sperm domain containing 2. (518 aa)
VAPBVAMP associated protein B and C. (243 aa)
PLXNB1Plexin B1. (2137 aa)
WHAMMWASP homolog associated with actin, golgi membranes and microtubules. (809 aa)
PIK3R2Uncharacterized protein. (726 aa)
ANKFY1Ankyrin repeat and FYVE domain containing 1. (1170 aa)
LBRLamin B receptor. (618 aa)
ARHGAP17Rho GTPase activating protein 17. (918 aa)
GOLGA2Uncharacterized protein. (1014 aa)
VANGL1Vang-like protein. (524 aa)
PGRMC2Progesterone receptor membrane component 2; Belongs to the cytochrome b5 family. (247 aa)
DIAPH3Diaphanous related formin 3. (1191 aa)
ARHGAP35Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase- activating protein [...] (1516 aa)
EMDEmerin. (260 aa)
TOR1AIP1Torsin 1A interacting protein 1. (597 aa)
RACGAP1Rac GTPase activating protein 1. (632 aa)
VRK2VRK serine/threonine kinase 2. (490 aa)
RAB7ARas-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] (228 aa)
MCAMMelanoma cell adhesion molecule. (723 aa)
ARHGAP5Rho GTPase activating protein 5. (1503 aa)
STEAP3STEAP3 metalloreductase. (654 aa)
ACTN1Actinin alpha 1. (956 aa)
CPNE8Copine 8. (615 aa)
ELOVL7DEP domain containing 1B. (725 aa)
AKAP12A-kinase anchoring protein 12. (1760 aa)
ARHGAP32Rho GTPase activating protein 32. (2113 aa)
LMNB1Lamin B1; Belongs to the intermediate filament family. (513 aa)
FILIP1Filamin A interacting protein 1. (1203 aa)
DIAPH2Diaphanous related formin 2. (1106 aa)
CHCHD6MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (2248 aa)
ARHGAP26Rho GTPase activating protein 26. (936 aa)
ARHGAP21Rho GTPase activating protein 21. (1940 aa)
ESYT1Extended synaptotagmin 1. (1049 aa)
VAMP3Vesicle associated membrane protein 3. (145 aa)
CAPZBCapping actin protein of muscle Z-line subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (451 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.