(16 nodes) RHOJ GTPase cycle network (Canis lupus familiaris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
	ARHGAP1	Cdc42 GTPase-activating protein. (439 aa)
	TRIO	Trio Rho guanine nucleotide exchange factor. (3053 aa)
	PIK3R2	Uncharacterized protein. (726 aa)
	RHOJ	Ras homolog family member J. (214 aa)
	SYDE1	Synapse defective Rho GTPase homolog 1. (735 aa)
	OPHN1	Oligophrenin 1. (802 aa)
	OCRL	OCRL inositol polyphosphate-5-phosphatase. (881 aa)
	PREX1	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1585 aa)
	ARHGAP35	Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase- activating protein [...] (1516 aa)
	ARHGAP5	Rho GTPase activating protein 5. (1503 aa)
	ELOVL7	DEP domain containing 1B. (725 aa)
	ARHGAP32	Rho GTPase activating protein 32. (2113 aa)
	ARHGAP26	Rho GTPase activating protein 26. (936 aa)
	DOCK8	Dedicator of cytokinesis 8; Belongs to the DOCK family. (2093 aa)
	ARHGAP21	Rho GTPase activating protein 21. (1940 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP1	ELOVL7	ENSCAFP00000013467	ENSCAFP00000051437	Cdc42 GTPase-activating protein.	DEP domain containing 1B.	0.450
ARHGAP1	RHOJ	ENSCAFP00000013467	ENSCAFP00000023197	Cdc42 GTPase-activating protein.	Ras homolog family member J.	0.591
ARHGAP21	RHOJ	ENSCAFP00000061254	ENSCAFP00000023197	Rho GTPase activating protein 21.	Ras homolog family member J.	0.462
ARHGAP26	RHOJ	ENSCAFP00000058275	ENSCAFP00000023197	Rho GTPase activating protein 26.	Ras homolog family member J.	0.432
ARHGAP32	RHOJ	ENSCAFP00000054528	ENSCAFP00000023197	Rho GTPase activating protein 32.	Ras homolog family member J.	0.471
ARHGAP35	ARHGAP5	ENSCAFP00000036971	ENSCAFP00000047479	Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase- activating protein [...]	Rho GTPase activating protein 5.	0.900
ARHGAP35	RHOJ	ENSCAFP00000036971	ENSCAFP00000023197	Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase- activating protein [...]	Ras homolog family member J.	0.534
ARHGAP5	ARHGAP35	ENSCAFP00000047479	ENSCAFP00000036971	Rho GTPase activating protein 5.	Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase- activating protein [...]	0.900
ARHGAP5	RHOJ	ENSCAFP00000047479	ENSCAFP00000023197	Rho GTPase activating protein 5.	Ras homolog family member J.	0.520
DOCK8	RHOJ	ENSCAFP00000060841	ENSCAFP00000023197	Dedicator of cytokinesis 8; Belongs to the DOCK family.	Ras homolog family member J.	0.645
ELOVL7	ARHGAP1	ENSCAFP00000051437	ENSCAFP00000013467	DEP domain containing 1B.	Cdc42 GTPase-activating protein.	0.450
ELOVL7	PIK3R1	ENSCAFP00000051437	ENSCAFP00000011322	DEP domain containing 1B.	Phosphoinositide-3-kinase regulatory subunit 1.	0.400
ELOVL7	PIK3R2	ENSCAFP00000051437	ENSCAFP00000022072	DEP domain containing 1B.	Uncharacterized protein.	0.403
ELOVL7	RHOJ	ENSCAFP00000051437	ENSCAFP00000023197	DEP domain containing 1B.	Ras homolog family member J.	0.419
OCRL	PIK3R1	ENSCAFP00000027583	ENSCAFP00000011322	OCRL inositol polyphosphate-5-phosphatase.	Phosphoinositide-3-kinase regulatory subunit 1.	0.675
OCRL	PIK3R2	ENSCAFP00000027583	ENSCAFP00000022072	OCRL inositol polyphosphate-5-phosphatase.	Uncharacterized protein.	0.739
OCRL	RHOJ	ENSCAFP00000027583	ENSCAFP00000023197	OCRL inositol polyphosphate-5-phosphatase.	Ras homolog family member J.	0.441
OPHN1	RHOJ	ENSCAFP00000024556	ENSCAFP00000023197	Oligophrenin 1.	Ras homolog family member J.	0.440
OPHN1	TRIO	ENSCAFP00000024556	ENSCAFP00000013586	Oligophrenin 1.	Trio Rho guanine nucleotide exchange factor.	0.415
PIK3R1	ELOVL7	ENSCAFP00000011322	ENSCAFP00000051437	Phosphoinositide-3-kinase regulatory subunit 1.	DEP domain containing 1B.	0.400