STRINGSTRING
TICAM2 TICAM2 TRAF6 TRAF6 RIPK1 RIPK1 CHUK CHUK UBA52 UBA52 BIRC2 BIRC2 SARM1 SARM1 IKBKG IKBKG TLR4 TLR4 RPS27A RPS27A TICAM1 TICAM1 UBE2D2 UBE2D2 UBE2D1 UBE2D1 UBE2N-2 UBE2N-2 UBE2V1 UBE2V1 LY96 LY96 UBE2D3 UBE2D3 RIPK3 RIPK3 IKBKB IKBKB BIRC3 BIRC3 ENSCAFP00000050780 ENSCAFP00000050780
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TICAM2TIR domain-containing protein. (238 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (580 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (669 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
BIRC2Baculoviral IAP repeat containing 2. (617 aa)
SARM1Sterile alpha and TIR motif containing 1. (724 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (751 aa)
UBE2D2Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
UBE2N-2UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
UBE2V1Ubiquitin conjugating enzyme E2 V1. (147 aa)
LY96Lymphocyte antigen 96. (160 aa)
UBE2D3UBIQUITIN_CONJUGAT_2 domain-containing protein. (146 aa)
RIPK3Protein kinase domain-containing protein. (423 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
BIRC3Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...] (635 aa)
ENSCAFP00000050780Ubiquitin-like domain-containing protein. (151 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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