(53 nodes) Cytoprotection by HMOX1 network (Canis lupus familiaris)

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	SCO2	SCO cytochrome c oxidase assembly protein 2. (390 aa)
	HMOX1	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
	LRPPRC	Leucine rich pentatricopeptide repeat containing. (1393 aa)
	CYCS	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	COX18	Cytochrome c oxidase assembly factor COX18. (445 aa)
	NCOA1	Nuclear receptor coactivator. (1410 aa)
	SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (558 aa)
	NCOR2	Nuclear receptor corepressor 2. (2517 aa)
	TGS1	Trimethylguanosine synthase 1. (852 aa)
	FABP1	FABP domain-containing protein. (127 aa)
	NCOA6	Nuclear receptor coactivator 6. (2060 aa)
	CHD9	Chromodomain helicase DNA binding protein 9. (2902 aa)
	TACO1	Translational activator of cytochrome c oxidase I. (298 aa)
	HELZ2	Helicase with zinc finger 2. (2974 aa)
	F1PYD3_CANLF	Cytochrome c oxidase subunit 6A, mitochondrial. (110 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (514 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
	COX16	Cytochrome c oxidase assembly factor COX16. (106 aa)
	ABCC1	Multidrug resistance-associated protein 1; Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (By similarity). Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (By similarity). [...] (1541 aa)
	COX11	Cytochrome c oxidase copper chaperone COX11. (305 aa)
	HMOX2	Heme oxygenase 2. (316 aa)
	COX4I1	Cytochrome c oxidase subunit 4I1. (169 aa)
	COX1	Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (514 aa)
	COX2	Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (227 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	LOC612644	Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (86 aa)
	COX7A2L	Cytochrome c oxidase subunit 7A2 like. (114 aa)
	SCO1	SCO cytochrome c oxidase assembly protein 1. (304 aa)
	COX14	Cytochrome c oxidase assembly factor COX14. (57 aa)
	CREBBP	CREB binding protein. (2442 aa)
	J9NWS5_CANLF	Uncharacterized protein; Belongs to the cytochrome c oxidase subunit 6A family. (92 aa)
	SIN3B	SIN3 transcription regulator family member B. (1125 aa)
	J9P0E1_CANLF	Uncharacterized protein. (69 aa)
	PTPN9	SIN3 transcription regulator family member A. (1303 aa)
	ENSCAFP00000043909	Uncharacterized protein. (79 aa)
	HM13	Histocompatibility minor 13. (421 aa)
	CARM1	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (706 aa)
	LOC100684983	Uncharacterized protein. (80 aa)
	TBL1X	Uncharacterized protein. (592 aa)
	BLVRA	Biliverdin reductase A. (401 aa)
	NDUFA4	Uncharacterized protein. (82 aa)
	ENSCAFP00000050726	Uncharacterized protein. (129 aa)
	BLVRB	Biliverdin reductase B. (245 aa)
	NCOR1	Nuclear receptor corepressor 1. (2542 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and [...] (568 aa)
	RXRA	Retinoid X receptor alpha. (556 aa)
	ENSCAFP00000058407	Uncharacterized protein. (169 aa)
	LOC609990	Uncharacterized protein. (63 aa)
	SURF1	SURF1-like protein; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Belongs to the SURF1 family. (352 aa)
	ENSCAFP00000060857	Uncharacterized protein; Belongs to the cytochrome c oxidase subunit 6A family. (85 aa)
	COX20	Cytochrome c oxidase assembly factor COX20. (163 aa)
	ENSCAFP00000065700	CHCH domain-containing protein. (95 aa)
	NCOA2	Nuclear receptor coactivator 2. (1568 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BLVRA	BLVRB	ENSCAFP00000049116	ENSCAFP00000051083	Biliverdin reductase A.	Biliverdin reductase B.	0.894
BLVRA	HMOX1	ENSCAFP00000049116	ENSCAFP00000002482	Biliverdin reductase A.	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.	0.980
BLVRA	HMOX2	ENSCAFP00000049116	ENSCAFP00000028330	Biliverdin reductase A.	Heme oxygenase 2.	0.957
BLVRB	BLVRA	ENSCAFP00000051083	ENSCAFP00000049116	Biliverdin reductase B.	Biliverdin reductase A.	0.894
BLVRB	COX1	ENSCAFP00000051083	ENSCAFP00000030311	Biliverdin reductase B.	Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...]	0.765
BLVRB	COX2	ENSCAFP00000051083	ENSCAFP00000030312	Biliverdin reductase B.	Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...]	0.719
BLVRB	COX4I1	ENSCAFP00000051083	ENSCAFP00000029506	Biliverdin reductase B.	Cytochrome c oxidase subunit 4I1.	0.476
BLVRB	ENSCAFP00000050726	ENSCAFP00000051083	ENSCAFP00000050726	Biliverdin reductase B.	Uncharacterized protein.	0.465
BLVRB	ENSCAFP00000058407	ENSCAFP00000051083	ENSCAFP00000058407	Biliverdin reductase B.	Uncharacterized protein.	0.601
BLVRB	ENSCAFP00000060857	ENSCAFP00000051083	ENSCAFP00000060857	Biliverdin reductase B.	Uncharacterized protein; Belongs to the cytochrome c oxidase subunit 6A family.	0.414
BLVRB	F1PYD3_CANLF	ENSCAFP00000051083	ENSCAFP00000019954	Biliverdin reductase B.	Cytochrome c oxidase subunit 6A, mitochondrial.	0.414
BLVRB	HM13	ENSCAFP00000051083	ENSCAFP00000044277	Biliverdin reductase B.	Histocompatibility minor 13.	0.648
BLVRB	HMOX1	ENSCAFP00000051083	ENSCAFP00000002482	Biliverdin reductase B.	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.	0.551
BLVRB	HMOX2	ENSCAFP00000051083	ENSCAFP00000028330	Biliverdin reductase B.	Heme oxygenase 2.	0.501
BLVRB	J9NWS5_CANLF	ENSCAFP00000051083	ENSCAFP00000037736	Biliverdin reductase B.	Uncharacterized protein; Belongs to the cytochrome c oxidase subunit 6A family.	0.414
BLVRB	LOC609990	ENSCAFP00000051083	ENSCAFP00000060126	Biliverdin reductase B.	Uncharacterized protein.	0.425
CARM1	CHD9	ENSCAFP00000044963	ENSCAFP00000014262	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Chromodomain helicase DNA binding protein 9.	0.448
CARM1	CREBBP	ENSCAFP00000044963	ENSCAFP00000036447	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	CREB binding protein.	0.729
CARM1	HDAC3	ENSCAFP00000044963	ENSCAFP00000030390	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.533
CARM1	HELZ2	ENSCAFP00000044963	ENSCAFP00000019101	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Helicase with zinc finger 2.	0.532