(13 nodes) IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation network (Canis lupus familiaris)

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Your Input:
	PELI1	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (580 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
	UBA52	Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
	PELI2	Pellino E3 ubiquitin protein ligase family member 2. (563 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	UBE2N-2	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
	UBE2V1	Ubiquitin conjugating enzyme E2 V1. (147 aa)
	PELI3	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (750 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
	ENSCAFP00000050780	Ubiquitin-like domain-containing protein. (151 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	ENSCAFP00000050780	ENSCAFP00000014093	ENSCAFP00000050780	Component of inhibitor of nuclear factor kappa B kinase complex.	Ubiquitin-like domain-containing protein.	0.536
CHUK	IKBKB	ENSCAFP00000014093	ENSCAFP00000048001	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.999
CHUK	IKBKG	ENSCAFP00000014093	ENSCAFP00000028998	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.999
CHUK	IRAK1	ENSCAFP00000014093	ENSCAFP00000047467	Component of inhibitor of nuclear factor kappa B kinase complex.	Interleukin 1 receptor associated kinase 1.	0.779
CHUK	PELI1	ENSCAFP00000014093	ENSCAFP00000004720	Component of inhibitor of nuclear factor kappa B kinase complex.	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.614
CHUK	PELI2	ENSCAFP00000014093	ENSCAFP00000022404	Component of inhibitor of nuclear factor kappa B kinase complex.	Pellino E3 ubiquitin protein ligase family member 2.	0.570
CHUK	PELI3	ENSCAFP00000014093	ENSCAFP00000042927	Component of inhibitor of nuclear factor kappa B kinase complex.	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.570
CHUK	RPS27A	ENSCAFP00000014093	ENSCAFP00000031429	Component of inhibitor of nuclear factor kappa B kinase complex.	Ubiquitin-like domain-containing protein.	0.536
CHUK	TRAF6	ENSCAFP00000014093	ENSCAFP00000010159	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.979
CHUK	UBA52	ENSCAFP00000014093	ENSCAFP00000021714	Component of inhibitor of nuclear factor kappa B kinase complex.	Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...]	0.570
CHUK	UBE2N-2	ENSCAFP00000014093	ENSCAFP00000040601	Component of inhibitor of nuclear factor kappa B kinase complex.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.578
CHUK	UBE2V1	ENSCAFP00000014093	ENSCAFP00000041429	Component of inhibitor of nuclear factor kappa B kinase complex.	Ubiquitin conjugating enzyme E2 V1.	0.549
ENSCAFP00000050780	CHUK	ENSCAFP00000050780	ENSCAFP00000014093	Ubiquitin-like domain-containing protein.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.536
ENSCAFP00000050780	IKBKB	ENSCAFP00000050780	ENSCAFP00000048001	Ubiquitin-like domain-containing protein.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.536
ENSCAFP00000050780	IKBKG	ENSCAFP00000050780	ENSCAFP00000028998	Ubiquitin-like domain-containing protein.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.839
ENSCAFP00000050780	IRAK1	ENSCAFP00000050780	ENSCAFP00000047467	Ubiquitin-like domain-containing protein.	Interleukin 1 receptor associated kinase 1.	0.532
ENSCAFP00000050780	RPS27A	ENSCAFP00000050780	ENSCAFP00000031429	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.405
ENSCAFP00000050780	TRAF6	ENSCAFP00000050780	ENSCAFP00000010159	Ubiquitin-like domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.985
ENSCAFP00000050780	UBA52	ENSCAFP00000050780	ENSCAFP00000021714	Ubiquitin-like domain-containing protein.	Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...]	0.972
ENSCAFP00000050780	UBE2N-2	ENSCAFP00000050780	ENSCAFP00000040601	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.808