STRINGSTRING
SKP1 SKP1 EP300 EP300 VCP VCP PSME4 PSME4 CUL1 CUL1 PSMB2 PSMB2 PSMD5 PSMD5 PSMC2 PSMC2 AKT2 AKT2 PSMC4 PSMC4 NPLOC4 NPLOC4 TRIM21 TRIM21 PSMF1 PSMF1 PSMD9 PSMD9 PSMC3 PSMC3 PSMD14 PSMD14 CUL3 CUL3 PSMB5 PSMB5 PSME1 PSME1 PSMA7 PSMA7 PSMD4 PSMD4 PSMD2 PSMD2 PSMB4 PSMB4 PSMC5 PSMC5 UBXN7 UBXN7 PSMA6 PSMA6 UBA52 UBA52 MUL1 MUL1 AKT3 AKT3 PSMB6 PSMB6 PSMD3 PSMD3 MAFK MAFK PSMB3 PSMB3 PSMC1 PSMC1 PSMA8 PSMA8 AKT1 AKT1 PSMD11 PSMD11 SKP2 SKP2 PSMA5 PSMA5 PSMB10 PSMB10 PSMB1 PSMB1 RPS27A RPS27A PSMD10 PSMD10 NFE2L2 NFE2L2 GSK3B GSK3B PSMD13 PSMD13 PSMD12 PSMD12 CREBBP CREBBP PSMB9 PSMB9 UFD1 UFD1 SRXN1 SRXN1 LOC100687259 LOC100687259 J9P2T7_CANLF J9P2T7_CANLF PSMD7 PSMD7 J9P7L3_CANLF J9P7L3_CANLF PSMA3 PSMA3 SESN2 SESN2 MAP1LC3B MAP1LC3B ENSCAFP00000047134 ENSCAFP00000047134 PSMA4 PSMA4 PSMC6 PSMC6 ENSCAFP00000050780 ENSCAFP00000050780 FBXL17 FBXL17 RBX1 RBX1 SESN1 SESN1 PSMB7 PSMB7 PSMA2 PSMA2 PSME2 PSME2 BACH1 BACH1 PSMD1 PSMD1 SQSTM1 SQSTM1 PSMA1 PSMA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
EP300E1A binding protein p300. (2308 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
PSME4Proteasome activator subunit 4. (1762 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMD5Uncharacterized protein. (500 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
AKT2AKT serine/threonine kinase 2. (557 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
NPLOC4NPL4 homolog, ubiquitin recognition factor. (615 aa)
TRIM21Tripartite motif containing 21. (469 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
PSMD9Proteasome 26S subunit, non-ATPase 9. (223 aa)
PSMC3AAA domain-containing protein; Belongs to the AAA ATPase family. (439 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (308 aa)
CUL3Cullin 3; Belongs to the cullin family. (746 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSME1Proteasome activator subunit 1. (249 aa)
PSMA7Proteasome endopeptidase complex. (178 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (377 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
UBXN7UBX domain-containing protein 7. (489 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (483 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PSMB6Proteasome subunit beta. (239 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
MAFKMAF bZIP transcription factor K. (156 aa)
PSMB3Proteasome subunit beta. (205 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
SKP2S-phase kinase associated protein 2. (436 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PSMB10Proteasome subunit beta. (272 aa)
PSMB1Proteasome subunit beta. (241 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (601 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (376 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
CREBBPCREB binding protein. (2442 aa)
PSMB9Proteasome subunit beta. (209 aa)
UFD1Ubiquitin recognition factor in ER associated degradation 1. (307 aa)
SRXN1Sulfiredoxin. (95 aa)
LOC100687259AAA domain-containing protein; Belongs to the AAA ATPase family. (365 aa)
J9P2T7_CANLFUncharacterized protein. (461 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
J9P7L3_CANLFThioredoxin domain-containing protein. (199 aa)
PSMA3Proteasome endopeptidase complex. (257 aa)
SESN2Sestrin 2. (485 aa)
MAP1LC3BUncharacterized protein. (269 aa)
ENSCAFP00000047134Proteasome endopeptidase complex. (216 aa)
PSMA4Proteasome subunit alpha 4. (290 aa)
PSMC6AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
ENSCAFP00000050780Ubiquitin-like domain-containing protein. (151 aa)
FBXL17F-box and leucine rich repeat protein 17. (308 aa)
RBX1Ring-box 1. (108 aa)
SESN1Sestrin 1. (658 aa)
PSMB7Proteasome subunit beta. (315 aa)
PSMA2Proteasome subunit alpha type. (295 aa)
PSME2Proteasome activator subunit 2. (253 aa)
BACH1BTB domain and CNC homolog 1. (773 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
SQSTM1Sequestosome 1. (551 aa)
PSMA1Proteasome subunit alpha type. (267 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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