(11 nodes) Putative peptidoglycan binding domain, and Tissue inhibitor of metalloproteinase family. network (Canis lupus familiaris)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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co-expression

protein homology

Your Input:
	TIMP4	Metalloproteinase inhibitor 4. (224 aa)
	MMP15	Matrix metallopeptidase 15. (618 aa)
	MMP2	Matrix metallopeptidase 2. (610 aa)
	MMP14	Matrix metallopeptidase 14. (582 aa)
	MMP8	Matrix metallopeptidase 8. (476 aa)
	MMP3	Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase (By similarity); Belongs to the peptidase M10A family. (478 aa)
	MMP9	Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). (732 aa)
	TIMP2	Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family. (177 aa)
	MMP1	Matrix metallopeptidase 1. (465 aa)
	TIMP3	TIMP metallopeptidase inhibitor 3. (366 aa)
	TIMP1	Metalloproteinase inhibitor 1. (359 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MMP1	MMP2	ENSCAFP00000038708	ENSCAFP00000013872	Matrix metallopeptidase 1.	Matrix metallopeptidase 2.	0.946
MMP1	MMP3	ENSCAFP00000038708	ENSCAFP00000022195	Matrix metallopeptidase 1.	Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase (By similarity); Belongs to the peptidase M10A family.	0.950
MMP1	MMP9	ENSCAFP00000038708	ENSCAFP00000035167	Matrix metallopeptidase 1.	Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity).	0.952
MMP1	TIMP1	ENSCAFP00000038708	ENSCAFP00000062428	Matrix metallopeptidase 1.	Metalloproteinase inhibitor 1.	0.953
MMP1	TIMP2	ENSCAFP00000038708	ENSCAFP00000035219	Matrix metallopeptidase 1.	Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family.	0.814
MMP1	TIMP3	ENSCAFP00000038708	ENSCAFP00000040576	Matrix metallopeptidase 1.	TIMP metallopeptidase inhibitor 3.	0.668
MMP1	TIMP4	ENSCAFP00000038708	ENSCAFP00000007442	Matrix metallopeptidase 1.	Metalloproteinase inhibitor 4.	0.603
MMP14	MMP15	ENSCAFP00000016472	ENSCAFP00000012558	Matrix metallopeptidase 14.	Matrix metallopeptidase 15.	0.548
MMP14	MMP2	ENSCAFP00000016472	ENSCAFP00000013872	Matrix metallopeptidase 14.	Matrix metallopeptidase 2.	0.711
MMP14	MMP9	ENSCAFP00000016472	ENSCAFP00000035167	Matrix metallopeptidase 14.	Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity).	0.463
MMP14	TIMP1	ENSCAFP00000016472	ENSCAFP00000062428	Matrix metallopeptidase 14.	Metalloproteinase inhibitor 1.	0.959
MMP14	TIMP2	ENSCAFP00000016472	ENSCAFP00000035219	Matrix metallopeptidase 14.	Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family.	0.999
MMP14	TIMP3	ENSCAFP00000016472	ENSCAFP00000040576	Matrix metallopeptidase 14.	TIMP metallopeptidase inhibitor 3.	0.747
MMP14	TIMP4	ENSCAFP00000016472	ENSCAFP00000007442	Matrix metallopeptidase 14.	Metalloproteinase inhibitor 4.	0.660
MMP15	MMP14	ENSCAFP00000012558	ENSCAFP00000016472	Matrix metallopeptidase 15.	Matrix metallopeptidase 14.	0.548
MMP15	MMP9	ENSCAFP00000012558	ENSCAFP00000035167	Matrix metallopeptidase 15.	Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity).	0.496
MMP15	TIMP1	ENSCAFP00000012558	ENSCAFP00000062428	Matrix metallopeptidase 15.	Metalloproteinase inhibitor 1.	0.769
MMP15	TIMP2	ENSCAFP00000012558	ENSCAFP00000035219	Matrix metallopeptidase 15.	Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family.	0.917
MMP15	TIMP3	ENSCAFP00000012558	ENSCAFP00000040576	Matrix metallopeptidase 15.	TIMP metallopeptidase inhibitor 3.	0.729
MMP15	TIMP4	ENSCAFP00000012558	ENSCAFP00000007442	Matrix metallopeptidase 15.	Metalloproteinase inhibitor 4.	0.514