6 items (Canis lupus familiaris) - STRING interaction network

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Your Input:
	TCF7L1	Transcription factor 7 like 1. (588 aa)
	JUP	Uncharacterized protein. (744 aa)
	NLK	Serine/threonine-protein kinase NLK; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhi [...] (527 aa)
	TCF7L2	Transcription factor 7 like 2. (565 aa)
	TCF7	Transcription factor 7. (484 aa)
	TERT	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1253 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
JUP	NLK	ENSCAFP00000023403	ENSCAFP00000027521	Uncharacterized protein.	Serine/threonine-protein kinase NLK; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhi [...]	0.554
JUP	TCF7	ENSCAFP00000023403	ENSCAFP00000043629	Uncharacterized protein.	Transcription factor 7.	0.962
JUP	TCF7L1	ENSCAFP00000023403	ENSCAFP00000011603	Uncharacterized protein.	Transcription factor 7 like 1.	0.961
JUP	TCF7L2	ENSCAFP00000023403	ENSCAFP00000039879	Uncharacterized protein.	Transcription factor 7 like 2.	0.963
NLK	JUP	ENSCAFP00000027521	ENSCAFP00000023403	Serine/threonine-protein kinase NLK; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhi [...]	Uncharacterized protein.	0.554
NLK	TCF7	ENSCAFP00000027521	ENSCAFP00000043629	Serine/threonine-protein kinase NLK; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhi [...]	Transcription factor 7.	0.963
NLK	TCF7L1	ENSCAFP00000027521	ENSCAFP00000011603	Serine/threonine-protein kinase NLK; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhi [...]	Transcription factor 7 like 1.	0.963
NLK	TCF7L2	ENSCAFP00000027521	ENSCAFP00000039879	Serine/threonine-protein kinase NLK; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhi [...]	Transcription factor 7 like 2.	0.963
TCF7	JUP	ENSCAFP00000043629	ENSCAFP00000023403	Transcription factor 7.	Uncharacterized protein.	0.962
TCF7	NLK	ENSCAFP00000043629	ENSCAFP00000027521	Transcription factor 7.	Serine/threonine-protein kinase NLK; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhi [...]	0.963
TCF7	TCF7L1	ENSCAFP00000043629	ENSCAFP00000011603	Transcription factor 7.	Transcription factor 7 like 1.	0.910
TCF7	TCF7L2	ENSCAFP00000043629	ENSCAFP00000039879	Transcription factor 7.	Transcription factor 7 like 2.	0.916
TCF7	TERT	ENSCAFP00000043629	ENSCAFP00000048407	Transcription factor 7.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]	0.900
TCF7L1	JUP	ENSCAFP00000011603	ENSCAFP00000023403	Transcription factor 7 like 1.	Uncharacterized protein.	0.961
TCF7L1	NLK	ENSCAFP00000011603	ENSCAFP00000027521	Transcription factor 7 like 1.	Serine/threonine-protein kinase NLK; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhi [...]	0.963
TCF7L1	TCF7	ENSCAFP00000011603	ENSCAFP00000043629	Transcription factor 7 like 1.	Transcription factor 7.	0.910
TCF7L1	TCF7L2	ENSCAFP00000011603	ENSCAFP00000039879	Transcription factor 7 like 1.	Transcription factor 7 like 2.	0.920
TCF7L1	TERT	ENSCAFP00000011603	ENSCAFP00000048407	Transcription factor 7 like 1.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]	0.946
TCF7L2	JUP	ENSCAFP00000039879	ENSCAFP00000023403	Transcription factor 7 like 2.	Uncharacterized protein.	0.963
TCF7L2	NLK	ENSCAFP00000039879	ENSCAFP00000027521	Transcription factor 7 like 2.	Serine/threonine-protein kinase NLK; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhi [...]	0.963