(22 nodes) Notch signaling pathway, and MamL-1 domain network (Canis lupus familiaris)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAML1	Mastermind like transcriptional coactivator 1. (1011 aa)
	NOTCH4	Notch receptor 4. (1773 aa)
	MFNG	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (315 aa)
	MAML3	Mastermind like transcriptional coactivator 3. (1098 aa)
	MAML2	Mastermind like transcriptional coactivator 2. (1124 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (689 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	RFNG	RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (205 aa)
	HEY1	Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...] (276 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (732 aa)
	NOTCH2	Notch receptor 2. (2726 aa)
	DTX2	Deltex E3 ubiquitin ligase 2. (621 aa)
	NOTCH3	Notch receptor 3. (2148 aa)
	LFNG	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (248 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1135 aa)
	HES5	Hes family bHLH transcription factor 5. (165 aa)
	NRARP	NOTCH regulated ankyrin repeat protein. (114 aa)
	HES3	Hes family bHLH transcription factor 3. (175 aa)
	HES2	Hes family bHLH transcription factor 2. (241 aa)
	NOTCH1	Notch receptor 1. (2565 aa)
	HES7	Hes family bHLH transcription factor 7. (345 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (513 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLL1	DLL4	ENSCAFP00000006075	ENSCAFP00000013852	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.915
DLL1	HES5	ENSCAFP00000006075	ENSCAFP00000028708	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 5.	0.761
DLL1	HEY1	ENSCAFP00000006075	ENSCAFP00000012336	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...]	0.612
DLL1	LFNG	ENSCAFP00000006075	ENSCAFP00000024136	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase.	0.598
DLL1	MAML1	ENSCAFP00000006075	ENSCAFP00000000502	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 1.	0.711
DLL1	MAML2	ENSCAFP00000006075	ENSCAFP00000006055	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 2.	0.587
DLL1	MAML3	ENSCAFP00000006075	ENSCAFP00000005512	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 3.	0.573
DLL1	MFNG	ENSCAFP00000006075	ENSCAFP00000002164	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase.	0.538
DLL1	NOTCH1	ENSCAFP00000006075	ENSCAFP00000029073	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.996
DLL1	NOTCH2	ENSCAFP00000006075	ENSCAFP00000015629	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 2.	0.986
DLL1	NOTCH3	ENSCAFP00000006075	ENSCAFP00000023739	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.982
DLL1	NOTCH4	ENSCAFP00000006075	ENSCAFP00000001124	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 4.	0.820
DLL1	NRARP	ENSCAFP00000006075	ENSCAFP00000028757	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	NOTCH regulated ankyrin repeat protein.	0.525
DLL1	RBPJ	ENSCAFP00000006075	ENSCAFP00000064615	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region.	0.779
DLL4	DLL1	ENSCAFP00000013852	ENSCAFP00000006075	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.915
DLL4	HES5	ENSCAFP00000013852	ENSCAFP00000028708	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 5.	0.595
DLL4	HEY1	ENSCAFP00000013852	ENSCAFP00000012336	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...]	0.824
DLL4	JAG2	ENSCAFP00000013852	ENSCAFP00000027180	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.440
DLL4	LFNG	ENSCAFP00000013852	ENSCAFP00000024136	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase.	0.603
DLL4	MAML1	ENSCAFP00000013852	ENSCAFP00000000502	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 1.	0.670