(7 nodes) Mixed, incl. Nuclear estrogen receptor activity, and PAS domain network (Canis lupus familiaris)

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Your Input:
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (598 aa)
	LOC609469	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (314 aa)
	PGR	Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor (By similarity). [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Belongs to the nuclear hormone receptor family. NR3 subfamily. (939 aa)
	NCOA1	Nuclear receptor coactivator. (1410 aa)
	SP1	Sp1 transcription factor. (782 aa)
	ESR2	Estrogen receptor 2. (549 aa)
	SRC	Tyrosine-protein kinase. (553 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ESR1	ESR2	ENSCAFP00000000624	ENSCAFP00000023305	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Estrogen receptor 2.	0.974
ESR1	LOC609469	ENSCAFP00000000624	ENSCAFP00000003011	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.924
ESR1	NCOA1	ENSCAFP00000000624	ENSCAFP00000006049	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator.	0.994
ESR1	PGR	ENSCAFP00000000624	ENSCAFP00000005906	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor (By similarity). [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.944
ESR1	SP1	ENSCAFP00000000624	ENSCAFP00000010330	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Sp1 transcription factor.	0.986
ESR1	SRC	ENSCAFP00000000624	ENSCAFP00000044994	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Tyrosine-protein kinase.	0.995
ESR2	ESR1	ENSCAFP00000023305	ENSCAFP00000000624	Estrogen receptor 2.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.974
ESR2	LOC609469	ENSCAFP00000023305	ENSCAFP00000003011	Estrogen receptor 2.	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.909
ESR2	NCOA1	ENSCAFP00000023305	ENSCAFP00000006049	Estrogen receptor 2.	Nuclear receptor coactivator.	0.988
ESR2	PGR	ENSCAFP00000023305	ENSCAFP00000005906	Estrogen receptor 2.	Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor (By similarity). [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.723
ESR2	SP1	ENSCAFP00000023305	ENSCAFP00000010330	Estrogen receptor 2.	Sp1 transcription factor.	0.963
ESR2	SRC	ENSCAFP00000023305	ENSCAFP00000044994	Estrogen receptor 2.	Tyrosine-protein kinase.	0.956
LOC609469	ESR1	ENSCAFP00000003011	ENSCAFP00000000624	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.924
LOC609469	ESR2	ENSCAFP00000003011	ENSCAFP00000023305	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Estrogen receptor 2.	0.909
LOC609469	NCOA1	ENSCAFP00000003011	ENSCAFP00000006049	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor coactivator.	0.460
LOC609469	SP1	ENSCAFP00000003011	ENSCAFP00000010330	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Sp1 transcription factor.	0.904
LOC609469	SRC	ENSCAFP00000003011	ENSCAFP00000044994	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Tyrosine-protein kinase.	0.911
NCOA1	ESR1	ENSCAFP00000006049	ENSCAFP00000000624	Nuclear receptor coactivator.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.994
NCOA1	ESR2	ENSCAFP00000006049	ENSCAFP00000023305	Nuclear receptor coactivator.	Estrogen receptor 2.	0.988
NCOA1	LOC609469	ENSCAFP00000006049	ENSCAFP00000003011	Nuclear receptor coactivator.	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.460