STRINGSTRING
STAT2 STAT2 IFNGR1 IFNGR1 IFNG IFNG IL3 IL3 IL5 IL5 IL13 IL13 IL4 IL4 IL2RB IL2RB CSF2RB CSF2RB IFNB1 IFNB1 IL15 IL15 IL2 IL2 IL2RA IL2RA IL5RA IL5RA IL7 IL7 LOC609830 LOC609830 CRLF2 CRLF2 CSF2RA CSF2RA IL3RA IL3RA IL7R IL7R LOC611642 LOC611642 IL13RA1 IL13RA1 CSF2 CSF2 IL15RA IL15RA LOC100686341 LOC100686341 JAK1 JAK1 TSLP TSLP IL2RG IL2RG IL4R IL4R IFNGR2 IFNGR2 LOC100683416 LOC100683416 IFNA5 IFNA5 LOC100687692 LOC100687692 STAT6 STAT6 STAT1 STAT1 LOC478404 LOC478404 IFNAR1 IFNAR1 TYK2 TYK2 IFNA7 IFNA7 LOC100687857 LOC100687857 IL9 IL9 IL13RA2 IL13RA2 LOC487739 LOC487739 IFNAR2 IFNAR2 LOC100683567 LOC100683567
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STAT2Signal transducer and activator of transcription. (844 aa)
IFNGR1Interferon gamma receptor 1. (475 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (143 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IL13Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. (131 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (132 aa)
IL2RBFibronectin type-III domain-containing protein. (556 aa)
CSF2RBColony stimulating factor 2 receptor beta common subunit. (902 aa)
IFNB1Interferon-beta. (186 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (155 aa)
IL2RAInterleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (268 aa)
IL5RAInterleukin 5 receptor subunit alpha. (420 aa)
IL7Interleukin 7. (155 aa)
LOC609830Uncharacterized protein. (569 aa)
CRLF2Cytokine receptor like factor 2. (373 aa)
CSF2RAColony stimulating factor 2 receptor alpha subunit. (576 aa)
IL3RAInterleukin 3 receptor subunit alpha. (489 aa)
IL7RInterleukin 7 receptor. (456 aa)
LOC611642Fibronectin type-III domain-containing protein. (505 aa)
IL13RA1Interleukin 13 receptor subunit alpha 1. (427 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (144 aa)
IL15RAInterleukin 15 receptor subunit alpha. (251 aa)
LOC100686341Fibronectin type-III domain-containing protein. (402 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
TSLPThymic stromal lymphopoietin. (117 aa)
IL2RGCytokine receptor common subunit gamma; Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). Belongs to the type I cytokine receptor family. Type 5 subfamily. (373 aa)
IL4RInterleukin 4 receptor. (835 aa)
IFNGR2Uncharacterized protein. (435 aa)
LOC100683416Uncharacterized protein. (178 aa)
IFNA5Interferon alpha-3; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (187 aa)
LOC100687692Uncharacterized protein. (187 aa)
STAT6Signal transducer and activator of transcription. (927 aa)
STAT1Signal transducer and activator of transcription. (774 aa)
LOC478404Uncharacterized protein. (528 aa)
IFNAR1Uncharacterized protein. (572 aa)
TYK2Tyrosine-protein kinase. (1173 aa)
IFNA7Interferon-alpha. (187 aa)
LOC100687857Uncharacterized protein. (187 aa)
IL9Interleukin 9. (139 aa)
IL13RA2Interleukin-13 receptor subunit alpha-2; Binds as a monomer with high affinity to interleukin-13 (IL13); Belongs to the type I cytokine receptor family. Type 5 subfamily. (406 aa)
LOC487739Uncharacterized protein. (363 aa)
IFNAR2Uncharacterized protein. (522 aa)
LOC100683567Uncharacterized protein. (196 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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