(18 nodes) Mixed, incl. Cellular response to interleukin-15, and Interleukin-4 and Interleukin-13 signaling network (Canis lupus familiaris)

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Your Input:
	IL13	Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. (131 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (132 aa)
	IL2RB	Fibronectin type-III domain-containing protein. (556 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (155 aa)
	IL2RA	Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (268 aa)
	IL7	Interleukin 7. (155 aa)
	CRLF2	Cytokine receptor like factor 2. (373 aa)
	IL7R	Interleukin 7 receptor. (456 aa)
	LOC611642	Fibronectin type-III domain-containing protein. (505 aa)
	IL13RA1	Interleukin 13 receptor subunit alpha 1. (427 aa)
	IL15RA	Interleukin 15 receptor subunit alpha. (251 aa)
	TSLP	Thymic stromal lymphopoietin. (117 aa)
	IL2RG	Cytokine receptor common subunit gamma; Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). Belongs to the type I cytokine receptor family. Type 5 subfamily. (373 aa)
	IL4R	Interleukin 4 receptor. (835 aa)
	STAT6	Signal transducer and activator of transcription. (927 aa)
	IL9	Interleukin 9. (139 aa)
	IL13RA2	Interleukin-13 receptor subunit alpha-2; Binds as a monomer with high affinity to interleukin-13 (IL13); Belongs to the type I cytokine receptor family. Type 5 subfamily. (406 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRLF2	IL13	ENSCAFP00000016256	ENSCAFP00000001250	Cytokine receptor like factor 2.	Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.	0.721
CRLF2	IL15	ENSCAFP00000016256	ENSCAFP00000005401	Cytokine receptor like factor 2.	Interleukin; Belongs to the IL-15/IL-21 family.	0.673
CRLF2	IL2	ENSCAFP00000016256	ENSCAFP00000005941	Cytokine receptor like factor 2.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.	0.680
CRLF2	IL2RB	ENSCAFP00000016256	ENSCAFP00000002178	Cytokine receptor like factor 2.	Fibronectin type-III domain-containing protein.	0.423
CRLF2	IL4	ENSCAFP00000016256	ENSCAFP00000001253	Cytokine receptor like factor 2.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.732
CRLF2	IL7	ENSCAFP00000016256	ENSCAFP00000012305	Cytokine receptor like factor 2.	Interleukin 7.	0.770
CRLF2	IL7R	ENSCAFP00000016256	ENSCAFP00000027663	Cytokine receptor like factor 2.	Interleukin 7 receptor.	0.993
CRLF2	IL9	ENSCAFP00000016256	ENSCAFP00000056083	Cytokine receptor like factor 2.	Interleukin 9.	0.691
CRLF2	TSLP	ENSCAFP00000016256	ENSCAFP00000040916	Cytokine receptor like factor 2.	Thymic stromal lymphopoietin.	0.993
IL13	CRLF2	ENSCAFP00000001250	ENSCAFP00000016256	Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.	Cytokine receptor like factor 2.	0.721
IL13	IL13RA1	ENSCAFP00000001250	ENSCAFP00000030717	Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.	Interleukin 13 receptor subunit alpha 1.	0.997
IL13	IL13RA2	ENSCAFP00000001250	ENSCAFP00000056821	Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.	Interleukin-13 receptor subunit alpha-2; Binds as a monomer with high affinity to interleukin-13 (IL13); Belongs to the type I cytokine receptor family. Type 5 subfamily.	0.998
IL13	IL15	ENSCAFP00000001250	ENSCAFP00000005401	Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.	Interleukin; Belongs to the IL-15/IL-21 family.	0.861
IL13	IL2	ENSCAFP00000001250	ENSCAFP00000005941	Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family.	0.887
IL13	IL2RA	ENSCAFP00000001250	ENSCAFP00000007785	Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.	Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.	0.784
IL13	IL2RB	ENSCAFP00000001250	ENSCAFP00000002178	Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.	Fibronectin type-III domain-containing protein.	0.687
IL13	IL2RG	ENSCAFP00000001250	ENSCAFP00000041465	Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.	Cytokine receptor common subunit gamma; Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). Belongs to the type I cytokine receptor family. Type 5 subfamily.	0.799
IL13	IL4	ENSCAFP00000001250	ENSCAFP00000001253	Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.951
IL13	IL4R	ENSCAFP00000001250	ENSCAFP00000044111	Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.	Interleukin 4 receptor.	0.988
IL13	IL7	ENSCAFP00000001250	ENSCAFP00000012305	Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.	Interleukin 7.	0.840