(26 nodes) IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, and MyD88-dependent toll-like receptor signaling pathway network (Canis lupus familiaris)

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Your Input:
	TICAM2	TIR domain-containing protein. (238 aa)
	TAB2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
	IRAK3	Interleukin 1 receptor associated kinase 3. (650 aa)
	TAB1	TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (964 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	MYD88	MYD88 innate immune signal transduction adaptor. (398 aa)
	IRAK2	Interleukin 1 receptor associated kinase 2. (621 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (580 aa)
	TLR2	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (802 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
	IRAK4	Interleukin 1 receptor associated kinase 4. (466 aa)
	NOD2	Uncharacterized protein. (1013 aa)
	TLR5	TIR domain-containing protein; Belongs to the Toll-like receptor family. (1093 aa)
	TAB3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
	MAP3K14	Mitogen-activated protein kinase kinase kinase 14. (955 aa)
	TLR6	Toll like receptor 6; Belongs to the Toll-like receptor family. (797 aa)
	TIRAP	TIR domain containing adaptor protein. (406 aa)
	TLR9-2	Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1032 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
	TLR1	Toll like receptor 1; Belongs to the Toll-like receptor family. (760 aa)
	TICAM1	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (751 aa)
	LY96	Lymphocyte antigen 96. (160 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (967 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (750 aa)
	TOLLIP	Toll interacting protein. (281 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IRAK1	IRAK2	ENSCAFP00000047467	ENSCAFP00000007680	Interleukin 1 receptor associated kinase 1.	Interleukin 1 receptor associated kinase 2.	0.905
IRAK1	IRAK3	ENSCAFP00000047467	ENSCAFP00000000535	Interleukin 1 receptor associated kinase 1.	Interleukin 1 receptor associated kinase 3.	0.794
IRAK1	IRAK4	ENSCAFP00000047467	ENSCAFP00000014260	Interleukin 1 receptor associated kinase 1.	Interleukin 1 receptor associated kinase 4.	0.996
IRAK1	LY96	ENSCAFP00000047467	ENSCAFP00000042952	Interleukin 1 receptor associated kinase 1.	Lymphocyte antigen 96.	0.550
IRAK1	MAP3K7	ENSCAFP00000047467	ENSCAFP00000004664	Interleukin 1 receptor associated kinase 1.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.794
IRAK1	MYD88	ENSCAFP00000047467	ENSCAFP00000007386	Interleukin 1 receptor associated kinase 1.	MYD88 innate immune signal transduction adaptor.	0.999
IRAK1	NOD1	ENSCAFP00000047467	ENSCAFP00000004572	Interleukin 1 receptor associated kinase 1.	Nucleotide binding oligomerization domain containing 1.	0.651
IRAK1	NOD2	ENSCAFP00000047467	ENSCAFP00000014425	Interleukin 1 receptor associated kinase 1.	Uncharacterized protein.	0.725
IRAK1	RIPK2	ENSCAFP00000047467	ENSCAFP00000013170	Interleukin 1 receptor associated kinase 1.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.609
IRAK1	TAB1	ENSCAFP00000047467	ENSCAFP00000001917	Interleukin 1 receptor associated kinase 1.	TGF-beta activated kinase 1 (MAP3K7) binding protein 1.	0.873
IRAK1	TAB2	ENSCAFP00000047467	ENSCAFP00000000532	Interleukin 1 receptor associated kinase 1.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.992
IRAK1	TAB3	ENSCAFP00000047467	ENSCAFP00000020263	Interleukin 1 receptor associated kinase 1.	TGF-beta activated kinase 1 (MAP3K7) binding protein 3.	0.843
IRAK1	TICAM2	ENSCAFP00000047467	ENSCAFP00000000299	Interleukin 1 receptor associated kinase 1.	TIR domain-containing protein.	0.507
IRAK1	TIRAP	ENSCAFP00000047467	ENSCAFP00000030551	Interleukin 1 receptor associated kinase 1.	TIR domain containing adaptor protein.	0.709
IRAK1	TLR1	ENSCAFP00000047467	ENSCAFP00000032660	Interleukin 1 receptor associated kinase 1.	Toll like receptor 1; Belongs to the Toll-like receptor family.	0.639
IRAK1	TLR2	ENSCAFP00000047467	ENSCAFP00000012269	Interleukin 1 receptor associated kinase 1.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.704
IRAK1	TLR3	ENSCAFP00000047467	ENSCAFP00000044568	Interleukin 1 receptor associated kinase 1.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.694
IRAK1	TLR4	ENSCAFP00000047467	ENSCAFP00000031395	Interleukin 1 receptor associated kinase 1.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.649
IRAK1	TLR5	ENSCAFP00000047467	ENSCAFP00000016726	Interleukin 1 receptor associated kinase 1.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.588
IRAK1	TLR6	ENSCAFP00000047467	ENSCAFP00000023836	Interleukin 1 receptor associated kinase 1.	Toll like receptor 6; Belongs to the Toll-like receptor family.	0.778