(5 nodes) Toll-like receptor 2 binding, and TRIF-mediated programmed cell death network (Canis lupus familiaris)

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Your Input:
	TLR2	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (802 aa)
	TLR6	Toll like receptor 6; Belongs to the Toll-like receptor family. (797 aa)
	TIRAP	TIR domain containing adaptor protein. (406 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
	LY96	Lymphocyte antigen 96. (160 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LY96	TIRAP	ENSCAFP00000042952	ENSCAFP00000030551	Lymphocyte antigen 96.	TIR domain containing adaptor protein.	0.555
LY96	TLR2	ENSCAFP00000042952	ENSCAFP00000012269	Lymphocyte antigen 96.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.910
LY96	TLR4	ENSCAFP00000042952	ENSCAFP00000031395	Lymphocyte antigen 96.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.964
LY96	TLR6	ENSCAFP00000042952	ENSCAFP00000023836	Lymphocyte antigen 96.	Toll like receptor 6; Belongs to the Toll-like receptor family.	0.729
TIRAP	LY96	ENSCAFP00000030551	ENSCAFP00000042952	TIR domain containing adaptor protein.	Lymphocyte antigen 96.	0.555
TIRAP	TLR2	ENSCAFP00000030551	ENSCAFP00000012269	TIR domain containing adaptor protein.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.988
TIRAP	TLR4	ENSCAFP00000030551	ENSCAFP00000031395	TIR domain containing adaptor protein.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.978
TIRAP	TLR6	ENSCAFP00000030551	ENSCAFP00000023836	TIR domain containing adaptor protein.	Toll like receptor 6; Belongs to the Toll-like receptor family.	0.975
TLR2	LY96	ENSCAFP00000012269	ENSCAFP00000042952	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	Lymphocyte antigen 96.	0.910
TLR2	TIRAP	ENSCAFP00000012269	ENSCAFP00000030551	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	TIR domain containing adaptor protein.	0.988
TLR2	TLR4	ENSCAFP00000012269	ENSCAFP00000031395	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.964
TLR2	TLR6	ENSCAFP00000012269	ENSCAFP00000023836	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	Toll like receptor 6; Belongs to the Toll-like receptor family.	0.999
TLR4	LY96	ENSCAFP00000031395	ENSCAFP00000042952	Toll like receptor 4; Belongs to the Toll-like receptor family.	Lymphocyte antigen 96.	0.964
TLR4	TIRAP	ENSCAFP00000031395	ENSCAFP00000030551	Toll like receptor 4; Belongs to the Toll-like receptor family.	TIR domain containing adaptor protein.	0.978
TLR4	TLR2	ENSCAFP00000031395	ENSCAFP00000012269	Toll like receptor 4; Belongs to the Toll-like receptor family.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.964
TLR4	TLR6	ENSCAFP00000031395	ENSCAFP00000023836	Toll like receptor 4; Belongs to the Toll-like receptor family.	Toll like receptor 6; Belongs to the Toll-like receptor family.	0.962
TLR6	LY96	ENSCAFP00000023836	ENSCAFP00000042952	Toll like receptor 6; Belongs to the Toll-like receptor family.	Lymphocyte antigen 96.	0.729
TLR6	TIRAP	ENSCAFP00000023836	ENSCAFP00000030551	Toll like receptor 6; Belongs to the Toll-like receptor family.	TIR domain containing adaptor protein.	0.975
TLR6	TLR2	ENSCAFP00000023836	ENSCAFP00000012269	Toll like receptor 6; Belongs to the Toll-like receptor family.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.999
TLR6	TLR4	ENSCAFP00000023836	ENSCAFP00000031395	Toll like receptor 6; Belongs to the Toll-like receptor family.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.962