STRINGSTRING
MYL6B MYL6B MYL1 MYL1 TNNI3 TNNI3 PPP1R12C PPP1R12C CALD1 CALD1 MYLK3 MYLK3 MYH7B MYH7B ACTA1 ACTA1 MYL9 MYL9 MYBPC3 MYBPC3 CSRP3 CSRP3 TNNI2 TNNI2 LOC483676 LOC483676 TNNI1 TNNI1 ACTN2 ACTN2 XIRP2 XIRP2 SLC9A1 SLC9A1 MYOZ2 MYOZ2 TMOD4 TMOD4 ACTN3 ACTN3 MYPN MYPN MYL4 MYL4 MYOZ1 MYOZ1 TPM2 TPM2 MYL5 MYL5 MYH8 MYH8 MYH1 MYH1 MYH2 MYH2 MYH3 MYH3 PPP1CC PPP1CC DMD DMD MYLK2 MYLK2 MYL7 MYL7 PPP1R14A PPP1R14A NEB NEB TNNT2 TNNT2 TAGLN TAGLN ENSCAFP00000043563 ENSCAFP00000043563 TPM3 TPM3 TCAP TCAP TNNC1 TNNC1 TTN TTN MARF1 MARF1 ENSCAFP00000047500 ENSCAFP00000047500 ACTG2 ACTG2 TPM1 TPM1 ROCK1 ROCK1 PPP1CB PPP1CB DES DES ACTC1 ACTC1 MYH6 MYH6 PDLIM3 PDLIM3 ENSCAFP00000054266 ENSCAFP00000054266 SPIB SPIB TNNT1 TNNT1 ANKRD1 ANKRD1 TNNT3 TNNT3 MYL10 MYL10 MYL6 MYL6 PPP1R12A PPP1R12A MYH9 MYH9 MYL3 MYL3 MYLPF MYLPF ENSCAFP00000057483 ENSCAFP00000057483 MYLK MYLK MYL12B MYL12B RBM20 RBM20 MYH10 MYH10 ENSCAFP00000061338 ENSCAFP00000061338 MYBPC1 MYBPC1 MYH14 MYH14 ACTA2 ACTA2 ENSCAFP00000063142 ENSCAFP00000063142 MYL2 MYL2 ROCK2 ROCK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYL6BMyosin light chain 6B. (209 aa)
MYL1Myosin light chain 1. (232 aa)
TNNI3Troponin I, cardiac muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (211 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (758 aa)
CALD1Caldesmon 1. (766 aa)
MYLK3Myosin light chain kinase 3. (850 aa)
MYH7BMyosin heavy chain 7B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1844 aa)
ACTA1Actin alpha 1, skeletal muscle. (377 aa)
MYL9Myosin light chain 9. (172 aa)
MYBPC3Myosin binding protein C, cardiac. (1293 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
TNNI2Troponin I2, fast skeletal type. (182 aa)
LOC483676Uncharacterized protein; Belongs to the actin family. (380 aa)
TNNI1Troponin I1, slow skeletal type. (270 aa)
ACTN2Actinin alpha 2. (894 aa)
XIRP2Xin actin binding repeat containing 2. (3291 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
MYOZ2Myozenin 2. (264 aa)
TMOD4Tropomodulin 4. (345 aa)
ACTN3Actinin alpha 3. (1061 aa)
MYPNMyopalladin. (1322 aa)
MYL4Myosin light chain 4. (299 aa)
MYOZ1Calsarcin 2. (297 aa)
TPM2Tropomyosin 2; Belongs to the tropomyosin family. (284 aa)
MYL5Myosin light chain 5. (289 aa)
MYH8Myosin-8; Muscle contraction. (1940 aa)
MYH1Myosin-1; Muscle contraction. (1953 aa)
MYH2Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity). (1940 aa)
MYH3Myosin heavy chain 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1940 aa)
PPP1CCSerine/threonine-protein phosphatase PP1-gamma catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- asso [...] (499 aa)
DMDDystrophin; Anchors the extracellular matrix to the cytoskeleton via F- actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. (3680 aa)
MYLK2Myosin light chain kinase 2. (634 aa)
MYL7Uncharacterized protein. (203 aa)
PPP1R14AProtein phosphatase 1 regulatory inhibitor subunit 14A. (77 aa)
NEBNebulin. (6526 aa)
TNNT2Troponin T2, cardiac type. (296 aa)
TAGLNTransgelin; Belongs to the calponin family. (325 aa)
ENSCAFP00000043563Uncharacterized protein. (100 aa)
TPM3Tropomyosin 3; Belongs to the tropomyosin family. (285 aa)
TCAPTitin-cap. (210 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (303 aa)
TTNTitin. (27097 aa)
MARF1Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1979 aa)
ENSCAFP00000047500Uncharacterized protein. (178 aa)
ACTG2Deoxyguanosine kinase. (521 aa)
TPM1Tropomyosin 1; Belongs to the tropomyosin family. (443 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1381 aa)
PPP1CBSerine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] (337 aa)
DESDesmin; Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-ancho [...] (644 aa)
ACTC1Actin alpha cardiac muscle 1. (447 aa)
MYH6Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1894 aa)
PDLIM3PDZ and LIM domain 3. (405 aa)
ENSCAFP00000054266Uncharacterized protein; Belongs to the tropomyosin family. (263 aa)
SPIBMyosin binding protein C, fast type. (1301 aa)
TNNT1Troponin T1, slow skeletal type. (328 aa)
ANKRD1Ankyrin repeat domain 1. (340 aa)
TNNT3Troponin T3, fast skeletal type. (340 aa)
MYL10Myosin light chain 10. (187 aa)
MYL6Uncharacterized protein. (158 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1084 aa)
MYH9Myosin-9; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (By similarity). Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1981 aa)
MYL3Myosin light chain 3. (308 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (181 aa)
ENSCAFP00000057483Uncharacterized protein. (167 aa)
MYLKMyosin light chain kinase. (2017 aa)
MYL12BUncharacterized protein. (259 aa)
RBM20RNA binding motif protein 20. (1287 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2077 aa)
ENSCAFP00000061338Uncharacterized protein. (163 aa)
MYBPC1Myosin binding protein C, slow type. (1203 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2072 aa)
ACTA2Actin alpha 2, smooth muscle. (421 aa)
ENSCAFP00000063142Uncharacterized protein. (102 aa)
MYL2Myosin light chain 2. (175 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1483 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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