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MIP MIP SPRYD4 SPRYD4 KATNA1 KATNA1 RSPH3 RSPH3 SGSM3 SGSM3 TMOD1 TMOD1 ADD2 ADD2 ING3 ING3 ATAD2B ATAD2B DTNB DTNB RAB30 RAB30 CFAP61 CFAP61 SPTBN4 SPTBN4 KIAA1549L KIAA1549L KATNBL1 KATNBL1 AQP5 AQP5 KATNB1 KATNB1 GPD2 GPD2 DMTN DMTN ADD3 ADD3 C18H11orf24 C18H11orf24 C27H12orf71 C27H12orf71 MSANTD2 MSANTD2 EPB42 EPB42 ANK3 ANK3 GUCD1 GUCD1 ATP13A1 ATP13A1 SLC4A1 SLC4A1 SAMD8 SAMD8 TPM4 TPM4 KDM5C KDM5C AQP9 AQP9 AQP8 AQP8 TMEM251 TMEM251 LOC100688010 LOC100688010 AQP4 AQP4 MIB2 MIB2 PPP1R21 PPP1R21 F1PXE0_CANLF F1PXE0_CANLF H9GX31_CANLF H9GX31_CANLF GYPC GYPC THEGL THEGL GYPA GYPA ANK2 ANK2 RIN2 RIN2 AQP2 AQP2 RHAG RHAG LOC480492 LOC480492 J9P6F4_CANLF J9P6F4_CANLF GDPD4 GDPD4 DENND10 DENND10 NEURL1 NEURL1 ENSCAFP00000043564 ENSCAFP00000043564 AQP1 AQP1 FUOM FUOM DENND11 DENND11 DTD1 DTD1 AQP11 AQP11 HAPLN3 HAPLN3 KATNAL1 KATNAL1 EPB41 EPB41 ENSCAFP00000049860 ENSCAFP00000049860 AQP3 AQP3 ENSCAFP00000051653 ENSCAFP00000051653 RALGAPA2 RALGAPA2 ARFGEF1 ARFGEF1 PLEKHA5 PLEKHA5 CXXC4 CXXC4 XYLB XYLB SUN3 SUN3 GK GK SPTBN4-2 SPTBN4-2 TMOD2 TMOD2 DBI DBI RHCE RHCE ADD1 ADD1 ENSCAFP00000066193 ENSCAFP00000066193 ADGRA1 ADGRA1 ENSCAFP00000066757 ENSCAFP00000066757
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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MIPLens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (By similarity). Belongs to the MIP/aquaporin (TC 1.A.8) family. (263 aa)
SPRYD4SPRY domain containing 4. (254 aa)
KATNA1Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal p [...] (491 aa)
RSPH3Radial spoke head 3. (417 aa)
SGSM3Small G protein signaling modulator 3. (751 aa)
TMOD1Tropomodulin 1. (359 aa)
ADD2Adducin 2. (722 aa)
ING3Inhibitor of growth protein. (418 aa)
ATAD2BATPase family AAA domain containing 2B. (1458 aa)
DTNBZZ-type domain-containing protein. (904 aa)
RAB30RAB30, member RAS oncogene family. (203 aa)
CFAP61Cilia and flagella associated protein 61. (1237 aa)
SPTBN4Spectrin beta, non-erythrocytic 4. (844 aa)
KIAA1549LKIAA1549 like. (1821 aa)
KATNBL1Katanin regulatory subunit B1 like 1. (304 aa)
AQP5Aquaporin 5; Belongs to the MIP/aquaporin (TC 1.A.8) family. (147 aa)
KATNB1Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Micr [...] (655 aa)
GPD2Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (713 aa)
DMTNDematin actin binding protein. (399 aa)
ADD3Adducin 3. (706 aa)
C18H11orf24Chromosome 18 C11orf24 homolog. (395 aa)
C27H12orf71Chromosome 27 C12orf71 homolog. (319 aa)
MSANTD2Myb/SANT DNA binding domain containing 2. (643 aa)
EPB42Erythrocyte membrane protein band 4.2. (730 aa)
ANK3Ankyrin 3. (4380 aa)
GUCD1Uncharacterized protein. (240 aa)
ATP13A1Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1206 aa)
SLC4A1Anion exchange protein. (930 aa)
SAMD8Sterile alpha motif domain containing 8. (591 aa)
TPM4Tropomyosin 4; Belongs to the tropomyosin family. (284 aa)
KDM5CLysine-specific demethylase 5C; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. (1559 aa)
AQP9Aquaporin 9; Belongs to the MIP/aquaporin (TC 1.A.8) family. (295 aa)
AQP8Aquaporin 8; Belongs to the MIP/aquaporin (TC 1.A.8) family. (263 aa)
TMEM251Transmembrane protein 251. (163 aa)
LOC100688010Uncharacterized protein. (264 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (348 aa)
MIB2Mindbomb E3 ubiquitin protein ligase 2. (1005 aa)
PPP1R21Protein phosphatase 1 regulatory subunit 21. (780 aa)
F1PXE0_CANLFUncharacterized protein. (289 aa)
H9GX31_CANLFUncharacterized protein; Belongs to the glycosyl hydrolase 22 family. (90 aa)
GYPCGlycophorin C. (76 aa)
THEGLTheg spermatid protein like. (478 aa)
GYPAGlycophorin-A; Glycophorin A is the major intrinsic membrane sialoglycoprotein of the erythrocyte. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane (By similarity). (129 aa)
ANK2Ankyrin 2. (3953 aa)
RIN2Ras and Rab interactor 2. (922 aa)
AQP2Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
RHAGAmmonium transporter Rh type A; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. Involved in ammonia transport across the erythrocyte membrane. Seems to act in monovalent cation transport. (415 aa)
LOC480492Lysozyme B; Belongs to the glycosyl hydrolase 22 family. (148 aa)
J9P6F4_CANLFKRAB domain-containing protein. (217 aa)
GDPD4Glycerophosphodiester phosphodiesterase domain containing 4. (750 aa)
DENND10Family with sequence similarity 45 member A. (394 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (580 aa)
ENSCAFP00000043564annotation not available (252 aa)
AQP1Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (373 aa)
FUOMUncharacterized protein. (349 aa)
DENND11KIAA1147. (416 aa)
DTD1D-aminoacyl-tRNA deacylase. (357 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (283 aa)
HAPLN3Hyaluronan and proteoglycan link protein 3. (519 aa)
KATNAL1Katanin p60 ATPase-containing subunit A-like 1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neur [...] (532 aa)
EPB41Protein 4.1; Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase. (1039 aa)
ENSCAFP00000049860Uncharacterized protein. (490 aa)
AQP3Uncharacterized protein. (570 aa)
ENSCAFP00000051653Uncharacterized protein. (109 aa)
RALGAPA2Ral GTPase activating protein catalytic alpha subunit 2. (1921 aa)
ARFGEF1ADP ribosylation factor guanine nucleotide exchange factor 1. (1849 aa)
PLEKHA5Pleckstrin homology domain containing A5. (1284 aa)
CXXC4CXXC finger protein 4. (159 aa)
XYLBXylulokinase. (586 aa)
SUN3Sad1 and UNC84 domain containing 3. (413 aa)
GKUncharacterized protein; Belongs to the FGGY kinase family. (567 aa)
SPTBN4-2Uncharacterized protein. (675 aa)
TMOD2Tropomodulin 2. (356 aa)
DBIAcyl-CoA-binding protein. (396 aa)
RHCEAmmonium_transp domain-containing protein; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. (444 aa)
ADD1Adducin 1. (825 aa)
ENSCAFP00000066193Uncharacterized protein. (114 aa)
ADGRA1Adhesion G protein-coupled receptor A1. (584 aa)
ENSCAFP00000066757Uncharacterized protein. (120 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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