(23 nodes) Mixed, incl. Class II Aldolase and Adducin N-terminal domain, and Pointed-end actin filament capping network (Canis lupus familiaris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TMOD1	Tropomodulin 1. (359 aa)
	ADD2	Adducin 2. (722 aa)
	CFAP61	Cilia and flagella associated protein 61. (1237 aa)
	DMTN	Dematin actin binding protein. (399 aa)
	ADD3	Adducin 3. (706 aa)
	EPB42	Erythrocyte membrane protein band 4.2. (730 aa)
	ANK3	Ankyrin 3. (4380 aa)
	GUCD1	Uncharacterized protein. (240 aa)
	SLC4A1	Anion exchange protein. (930 aa)
	TPM4	Tropomyosin 4; Belongs to the tropomyosin family. (284 aa)
	GYPC	Glycophorin C. (76 aa)
	THEGL	Theg spermatid protein like. (478 aa)
	GYPA	Glycophorin-A; Glycophorin A is the major intrinsic membrane sialoglycoprotein of the erythrocyte. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane (By similarity). (129 aa)
	ANK2	Ankyrin 2. (3953 aa)
	RIN2	Ras and Rab interactor 2. (922 aa)
	RHAG	Ammonium transporter Rh type A; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. Involved in ammonia transport across the erythrocyte membrane. Seems to act in monovalent cation transport. (415 aa)
	EPB41	Protein 4.1; Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase. (1039 aa)
	RALGAPA2	Ral GTPase activating protein catalytic alpha subunit 2. (1921 aa)
	CXXC4	CXXC finger protein 4. (159 aa)
	SUN3	Sad1 and UNC84 domain containing 3. (413 aa)
	TMOD2	Tropomodulin 2. (356 aa)
	RHCE	Ammonium_transp domain-containing protein; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. (444 aa)
	ADD1	Adducin 1. (825 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADD1	ADD2	ENSCAFP00000065621	ENSCAFP00000005087	Adducin 1.	Adducin 2.	0.963
ADD1	ADD3	ENSCAFP00000065621	ENSCAFP00000015741	Adducin 1.	Adducin 3.	0.949
ADD1	ANK2	ENSCAFP00000065621	ENSCAFP00000038225	Adducin 1.	Ankyrin 2.	0.674
ADD1	ANK3	ENSCAFP00000065621	ENSCAFP00000018833	Adducin 1.	Ankyrin 3.	0.675
ADD1	DMTN	ENSCAFP00000065621	ENSCAFP00000014298	Adducin 1.	Dematin actin binding protein.	0.857
ADD1	EPB41	ENSCAFP00000065621	ENSCAFP00000048815	Adducin 1.	Protein 4.1; Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.	0.844
ADD1	GYPC	ENSCAFP00000065621	ENSCAFP00000036216	Adducin 1.	Glycophorin C.	0.681
ADD1	RHAG	ENSCAFP00000065621	ENSCAFP00000040637	Adducin 1.	Ammonium transporter Rh type A; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. Involved in ammonia transport across the erythrocyte membrane. Seems to act in monovalent cation transport.	0.422
ADD1	SLC4A1	ENSCAFP00000065621	ENSCAFP00000020983	Adducin 1.	Anion exchange protein.	0.408
ADD1	TMOD1	ENSCAFP00000065621	ENSCAFP00000003547	Adducin 1.	Tropomodulin 1.	0.856
ADD1	TMOD2	ENSCAFP00000065621	ENSCAFP00000062539	Adducin 1.	Tropomodulin 2.	0.713
ADD2	ADD1	ENSCAFP00000005087	ENSCAFP00000065621	Adducin 2.	Adducin 1.	0.963
ADD2	ANK2	ENSCAFP00000005087	ENSCAFP00000038225	Adducin 2.	Ankyrin 2.	0.638
ADD2	ANK3	ENSCAFP00000005087	ENSCAFP00000018833	Adducin 2.	Ankyrin 3.	0.646
ADD2	DMTN	ENSCAFP00000005087	ENSCAFP00000014298	Adducin 2.	Dematin actin binding protein.	0.891
ADD2	EPB41	ENSCAFP00000005087	ENSCAFP00000048815	Adducin 2.	Protein 4.1; Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.	0.869
ADD2	EPB42	ENSCAFP00000005087	ENSCAFP00000017635	Adducin 2.	Erythrocyte membrane protein band 4.2.	0.429
ADD2	GYPC	ENSCAFP00000005087	ENSCAFP00000036216	Adducin 2.	Glycophorin C.	0.586
ADD2	RHAG	ENSCAFP00000005087	ENSCAFP00000040637	Adducin 2.	Ammonium transporter Rh type A; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. Involved in ammonia transport across the erythrocyte membrane. Seems to act in monovalent cation transport.	0.569
ADD2	RHCE	ENSCAFP00000005087	ENSCAFP00000063512	Adducin 2.	Ammonium_transp domain-containing protein; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.	0.403