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| | GLS2 | Glutaminase 2. (603 aa) |
| | SHMT2 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (549 aa) |
| | PHYKPL | 5-phosphohydroxy-L-lysine phospho-lyase. (583 aa) |
| | ARG1 | Arginase. (322 aa) |
| | MTHFD1L | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (936 aa) |
| | GCAT | Glycine C-acetyltransferase. (430 aa) |
| | AHCYL2 | Adenosylhomocysteinase like 2; Belongs to the adenosylhomocysteinase family. (648 aa) |
| | GNMT | Glycine N-methyltransferase. (295 aa) |
| | PPAT | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (517 aa) |
| | GRHPR | Glyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa) |
| | LOC100856577 | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Belongs to the acireductone dioxygenase (ARD) family. (139 aa) |
| | AASS | Aminoadipate-semialdehyde synthase. (920 aa) |
| | GLUD1-2 | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (490 aa) |
| | THNSL1 | Threonine synthase like 1. (737 aa) |
| | HAO1 | Hydroxyacid oxidase 1. (370 aa) |
| | DNMT3B | DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (870 aa) |
| | AADAT | Aminoadipate aminotransferase. (551 aa) |
| | MAT2A | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (413 aa) |
| | ALDH18A1 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (795 aa) |
| | MTHFD2 | Uncharacterized protein. (441 aa) |
| | ENOPH1 | Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (366 aa) |
| | PPP1R16B | Protein phosphatase 1 regulatory subunit 16B. (568 aa) |
| | BHMT | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. (407 aa) |
| | BHMT2 | Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. (363 aa) |
| | DMGDH | Dimethylglycine dehydrogenase. (832 aa) |
| | HOGA1 | 4-hydroxy-2-oxoglutarate aldolase 1; Belongs to the DapA family. (327 aa) |
| | LOC100856570 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1011 aa) |
| | ACCS | 1-aminocyclopropane-1-carboxylate synthase homolog (inactive). (524 aa) |
| | GLS | Glutaminase. (754 aa) |
| | ALAS1 | 5'-aminolevulinate synthase 1. (774 aa) |
| | HAO2 | Hydroxyacid oxidase 2. (389 aa) |
| | MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (704 aa) |
| | PSPH | Phosphoserine phosphatase. (225 aa) |
| | CRP | Pentaxin. (248 aa) |
| | FTCD | Formimidoyltransferase cyclodeaminase. (541 aa) |
| | IMPDH2 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa) |
| | LOC607355 | Aminotran_5 domain-containing protein. (463 aa) |
| | GLUL | Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating [...] (413 aa) |
| | MTHFS | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (203 aa) |
| | OTC | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa) |
| | ATIC | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (592 aa) |
| | ALAS2 | 5-aminolevulinate synthase. (538 aa) |
| | NAGS | N-acetylglutamate synthase. (537 aa) |
| | LOC491550 | Beta_elim_lyase domain-containing protein. (495 aa) |
| | MED28 | Mediator complex subunit 28. (175 aa) |
| | L3HYPDH | Trans-L-3-hydroxyproline dehydratase. (359 aa) |
| | MTHFD1 | Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (935 aa) |
| | MRI1 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (368 aa) |
| | MAT2B | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. (334 aa) |
| | CRYM | Crystallin mu. (314 aa) |
| | SHMT1 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa) |
| | TYMS | Thymidylate synthetase. (314 aa) |
| | ADSS1 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (474 aa) |
| | PIPOX | Pipecolic acid and sarcosine oxidase. (392 aa) |
| | AHCYL1 | Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (547 aa) |
| | GCSH | Glycine cleavage system protein H. (306 aa) |
| | FPGS | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (588 aa) |
| | CTH | Cystathionine gamma-lyase. (547 aa) |
| | LOC608055 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (572 aa) |
| | AMT | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (403 aa) |
| | ODC1 | Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (448 aa) |
| | TAT | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (454 aa) |
| | OAT | Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (415 aa) |
| | DHFR | DHFR domain-containing protein. (135 aa) |
| | LOC487740 | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1019 aa) |
| | J9NVM0_CANLF | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (329 aa) |
| | J9NWV4_CANLF | Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (365 aa) |
| | CAD | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2242 aa) |
| | HYKK | Hydroxylysine kinase. (376 aa) |
| | CBS | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (549 aa) |
| | J9P975_CANLF | Aminotran_1_2 domain-containing protein. (251 aa) |
| | GPT | Glutamic--pyruvic transaminase. (153 aa) |
| | APIP | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. (436 aa) |
| | ACY1 | Uncharacterized protein. (708 aa) |
| | ENSCAFP00000044273 | ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (238 aa) |
| | ENSCAFP00000045150 | DHFR domain-containing protein. (135 aa) |
| | ENSCAFP00000045369 | Uncharacterized protein. (172 aa) |
| | ENSCAFP00000045471 | Aspartate aminotransferase. (402 aa) |
| | ENSCAFP00000047141 | Uncharacterized protein. (119 aa) |
| | ASS1 | Argininosuccinate synthase 1. (526 aa) |
| | CPS1 | Carbamoyl-phosphate synthase 1. (1532 aa) |
| | MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase. (1330 aa) |
| | GLDC | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1032 aa) |
| | ENSCAFP00000051631 | Uncharacterized protein. (119 aa) |
| | PHGDH | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (646 aa) |
| | GATM | Uncharacterized protein. (447 aa) |
| | MTAP | Methylthioadenosine phosphorylase. (356 aa) |
| | GLUD1 | ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (946 aa) |
| | ALDH1L2 | Aldehyde dehydrogenase 1 family member L2; Belongs to the aldehyde dehydrogenase family. (1077 aa) |
| | ALDH1L1 | Aldehyde dehydrogenase 1 family member L1; Belongs to the aldehyde dehydrogenase family. (560 aa) |
| | ADI1 | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Belongs to the acireductone dioxygenase (ARD) family. (159 aa) |
| | ENSCAFP00000056268 | 2-Hacid_dh domain-containing protein. (102 aa) |
| | ENSCAFP00000056380 | THF_DHG_CYH domain-containing protein. (110 aa) |
| | ARG2 | Arginase. (384 aa) |
| | KYAT1 | Kynurenine aminotransferase 1. (541 aa) |
| | LOC100855679 | Aminotran_5 domain-containing protein. (537 aa) |
| | ADSS2 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (655 aa) |
| | ENSCAFP00000057890 | GCV_T domain-containing protein. (279 aa) |
| | BCAT2 | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (592 aa) |
| | LOC477365 | Epimerase domain-containing protein. (442 aa) |
| | MTHFD2L | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. (347 aa) |
| | MTHFR | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (749 aa) |
| | ENSCAFP00000060674 | Uncharacterized protein. (69 aa) |
| | SARDH | Sarcosine dehydrogenase. (943 aa) |
| | ALDH7A1 | Aldehyde dehydrogenase 7 family member A1; Belongs to the aldehyde dehydrogenase family. (539 aa) |
| | MAT1A | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (428 aa) |
| | ENSCAFP00000063488 | AdoHcyase_NAD domain-containing protein. (294 aa) |
| | PSAT1 | Phosphoserine aminotransferase. (391 aa) |
| | ENSCAFP00000064683 | Uncharacterized protein. (65 aa) |
| | PFAS | Phosphoribosylformylglycinamidine synthase. (1368 aa) |
| | DAO | D-amino acid oxidase. (376 aa) |
| | ENSCAFP00000066135 | MGS domain-containing protein. (505 aa) |
