(15 nodes) Arginine biosynthesis, and Citrulline metabolic process network (Canis lupus familiaris)

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Your Input:
	GLS2	Glutaminase 2. (603 aa)
	ARG1	Arginase. (322 aa)
	GLUD1-2	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (490 aa)
	ALDH18A1	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (795 aa)
	GLS	Glutaminase. (754 aa)
	GLUL	Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating [...] (413 aa)
	OTC	Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa)
	NAGS	N-acetylglutamate synthase. (537 aa)
	ODC1	Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (448 aa)
	OAT	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (415 aa)
	CAD	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2242 aa)
	ACY1	Uncharacterized protein. (708 aa)
	ASS1	Argininosuccinate synthase 1. (526 aa)
	CPS1	Carbamoyl-phosphate synthase 1. (1532 aa)
	GLUD1	ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (946 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACY1	ALDH18A1	ENSCAFP00000043871	ENSCAFP00000012319	Uncharacterized protein.	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	0.629
ACY1	ARG1	ENSCAFP00000043871	ENSCAFP00000000548	Uncharacterized protein.	Arginase.	0.920
ACY1	ASS1	ENSCAFP00000043871	ENSCAFP00000047568	Uncharacterized protein.	Argininosuccinate synthase 1.	0.822
ACY1	CAD	ENSCAFP00000043871	ENSCAFP00000039642	Uncharacterized protein.	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase.	0.469
ACY1	CPS1	ENSCAFP00000043871	ENSCAFP00000049536	Uncharacterized protein.	Carbamoyl-phosphate synthase 1.	0.466
ACY1	NAGS	ENSCAFP00000043871	ENSCAFP00000021231	Uncharacterized protein.	N-acetylglutamate synthase.	0.414
ACY1	OAT	ENSCAFP00000043871	ENSCAFP00000035720	Uncharacterized protein.	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.767
ACY1	ODC1	ENSCAFP00000043871	ENSCAFP00000032017	Uncharacterized protein.	Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.527
ACY1	OTC	ENSCAFP00000043871	ENSCAFP00000020690	Uncharacterized protein.	Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily.	0.973
ALDH18A1	ACY1	ENSCAFP00000012319	ENSCAFP00000043871	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Uncharacterized protein.	0.629
ALDH18A1	ARG1	ENSCAFP00000012319	ENSCAFP00000000548	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Arginase.	0.518
ALDH18A1	ASS1	ENSCAFP00000012319	ENSCAFP00000047568	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Argininosuccinate synthase 1.	0.806
ALDH18A1	CAD	ENSCAFP00000012319	ENSCAFP00000039642	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase.	0.832
ALDH18A1	CPS1	ENSCAFP00000012319	ENSCAFP00000049536	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Carbamoyl-phosphate synthase 1.	0.826
ALDH18A1	GLS	ENSCAFP00000012319	ENSCAFP00000013987	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Glutaminase.	0.959
ALDH18A1	GLS2	ENSCAFP00000012319	ENSCAFP00000000194	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Glutaminase 2.	0.962
ALDH18A1	GLUD1	ENSCAFP00000012319	ENSCAFP00000053992	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.879
ALDH18A1	GLUD1-2	ENSCAFP00000012319	ENSCAFP00000006270	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.974
ALDH18A1	GLUL	ENSCAFP00000012319	ENSCAFP00000019307	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating [...]	0.916
ALDH18A1	NAGS	ENSCAFP00000012319	ENSCAFP00000021231	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	N-acetylglutamate synthase.	0.779