STRINGSTRING
SIRT3 SIRT3 LOC489397 LOC489397 BST1 BST1 NADK NADK QPRT QPRT NMNAT1 NMNAT1 NAPRT NAPRT NNMT NNMT CD38 CD38 NMNAT2 NMNAT2 NNT NNT NADSYN1 NADSYN1 SIRT4 SIRT4 NMRK1 NMRK1 SIRT2 SIRT2 NADK2 NADK2 NOL7 NOL7 NMNAT3 NMNAT3 NAMPT NAMPT
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (372 aa)
LOC489397Uncharacterized protein. (263 aa)
BST1Bone marrow stromal cell antigen 1. (311 aa)
NADKNAD kinase. (515 aa)
QPRTNicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (299 aa)
NMNAT1Nicotinamide-nucleotide adenylyltransferase. (279 aa)
NAPRTNicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (534 aa)
NNMTNicotinamide N-methyltransferase. (264 aa)
CD38CD38 molecule. (361 aa)
NMNAT2Nicotinamide nucleotide adenylyltransferase 2. (333 aa)
NNTNicotinamide nucleotide transhydrogenase. (1114 aa)
NADSYN1Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (714 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (345 aa)
NMRK1Nicotinamide riboside kinase 1. (227 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (334 aa)
NADK2NAD kinase 2, mitochondrial. (625 aa)
NOL7NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinyla [...] (417 aa)
NMNAT3Nicotinamide-nucleotide adenylyltransferase. (293 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (534 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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