(5 nodes) NADP biosynthetic process, and Glutaminase activity network (Canis lupus familiaris)

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Your Input:
	NADK	NAD kinase. (515 aa)
	NMNAT1	Nicotinamide-nucleotide adenylyltransferase. (279 aa)
	NADSYN1	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (714 aa)
	SIRT4	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (345 aa)
	NADK2	NAD kinase 2, mitochondrial. (625 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NADK	NADK2	ENSCAFP00000028345	ENSCAFP00000055194	NAD kinase.	NAD kinase 2, mitochondrial.	0.949
NADK	NADSYN1	ENSCAFP00000028345	ENSCAFP00000052521	NAD kinase.	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	0.953
NADK	NMNAT1	ENSCAFP00000028345	ENSCAFP00000039234	NAD kinase.	Nicotinamide-nucleotide adenylyltransferase.	0.955
NADK	SIRT4	ENSCAFP00000028345	ENSCAFP00000053475	NAD kinase.	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	0.941
NADK2	NADK	ENSCAFP00000055194	ENSCAFP00000028345	NAD kinase 2, mitochondrial.	NAD kinase.	0.949
NADK2	NADSYN1	ENSCAFP00000055194	ENSCAFP00000052521	NAD kinase 2, mitochondrial.	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	0.945
NADK2	NMNAT1	ENSCAFP00000055194	ENSCAFP00000039234	NAD kinase 2, mitochondrial.	Nicotinamide-nucleotide adenylyltransferase.	0.926
NADK2	SIRT4	ENSCAFP00000055194	ENSCAFP00000053475	NAD kinase 2, mitochondrial.	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	0.900
NADSYN1	NADK	ENSCAFP00000052521	ENSCAFP00000028345	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	NAD kinase.	0.953
NADSYN1	NADK2	ENSCAFP00000052521	ENSCAFP00000055194	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	NAD kinase 2, mitochondrial.	0.945
NADSYN1	NMNAT1	ENSCAFP00000052521	ENSCAFP00000039234	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	Nicotinamide-nucleotide adenylyltransferase.	0.993
NADSYN1	SIRT4	ENSCAFP00000052521	ENSCAFP00000053475	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	0.935
NMNAT1	NADK	ENSCAFP00000039234	ENSCAFP00000028345	Nicotinamide-nucleotide adenylyltransferase.	NAD kinase.	0.955
NMNAT1	NADK2	ENSCAFP00000039234	ENSCAFP00000055194	Nicotinamide-nucleotide adenylyltransferase.	NAD kinase 2, mitochondrial.	0.926
NMNAT1	NADSYN1	ENSCAFP00000039234	ENSCAFP00000052521	Nicotinamide-nucleotide adenylyltransferase.	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	0.993
NMNAT1	SIRT4	ENSCAFP00000039234	ENSCAFP00000053475	Nicotinamide-nucleotide adenylyltransferase.	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	0.919
SIRT4	NADK	ENSCAFP00000053475	ENSCAFP00000028345	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	NAD kinase.	0.941
SIRT4	NADK2	ENSCAFP00000053475	ENSCAFP00000055194	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	NAD kinase 2, mitochondrial.	0.900
SIRT4	NADSYN1	ENSCAFP00000053475	ENSCAFP00000052521	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	0.935
SIRT4	NMNAT1	ENSCAFP00000053475	ENSCAFP00000039234	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	Nicotinamide-nucleotide adenylyltransferase.	0.919