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| | PRIM1 | Uncharacterized protein. (185 aa) |
| | POLI | DNA polymerase iota. (702 aa) |
| | RPA3-2 | Replication protein A3. (121 aa) |
| | DSCC1 | DNA replication and sister chromatid cohesion 1. (392 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1141 aa) |
| | FANCE | FA complementation group E. (539 aa) |
| | RMI1 | RecQ mediated genome instability 1. (634 aa) |
| | POT1 | Protection of telomeres 1. (785 aa) |
| | DBF4 | RUN domain containing 3B. (679 aa) |
| | POLH | DNA polymerase eta. (712 aa) |
| | FANCG | FA complementation group G. (806 aa) |
| | MCM3 | Minichromosome maintenance complex component 3; Belongs to the MCM family. (817 aa) |
| | XPA | XPA, DNA damage recognition and repair factor. (273 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | RAD23B | RAD23 homolog B, nucleotide excision repair protein. (406 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (519 aa) |
| | POLD1 | DNA polymerase. (1107 aa) |
| | ORC3 | Origin recognition complex subunit 3. (773 aa) |
| | CLSPN | Claspin. (1339 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (908 aa) |
| | ORC5 | Origin recognition complex subunit 5. (435 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) |
| | RAD54L | RAD54 like. (747 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (314 aa) |
| | XPC | XPC complex subunit, DNA damage recognition and repair factor. (949 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (887 aa) |
| | MLH1 | MutL homolog 1. (757 aa) |
| | MBD4 | Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (572 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (989 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (279 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | FBH1 | F-box DNA helicase 1. (1046 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) |
| | NGLY1 | N-glycanase 1. (655 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (291 aa) |
| | FAAP100 | FA core complex associated protein 100. (918 aa) |
| | ERCC5 | Uncharacterized protein. (1627 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3446 aa) |
| | WRN | WRN RecQ like helicase. (1574 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1513 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1486 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (681 aa) |
| | PRIMPOL | Primase and DNA directed polymerase. (581 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (680 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | NEIL2 | Nei like DNA glycosylase 2. (373 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (431 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (427 aa) |
| | GINS3 | GINS complex subunit 3. (216 aa) |
| | MSH3 | MutS homolog 3; Component of the post-replicative DNA mismatch repair system (MMR). (1058 aa) |
| | RAD54B | RAD54 homolog B. (912 aa) |
| | POLK | DNA polymerase kappa. (861 aa) |
| | RFC5 | Replication factor C subunit 5. (339 aa) |
| | CHD1L | Chromodomain helicase DNA binding protein 1 like. (883 aa) |
| | DCLRE1A | DNA cross-link repair 1A. (1049 aa) |
| | POLQ | DNA polymerase theta. (2704 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (390 aa) |
| | CLCF1 | Cardiotrophin like cytokine factor 1. (261 aa) |
| | FANCB | FA complementation group B. (850 aa) |
| | BLM | BLM RecQ like helicase. (1420 aa) |
| | ATRIP | ATR interacting protein. (792 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (551 aa) |
| | POLA1 | DNA polymerase. (1467 aa) |
| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (700 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1017 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (737 aa) |
| | SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (961 aa) |
| | CDC45 | Cell division cycle 45. (569 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | WDHD1 | WD repeat and HMG-box DNA binding protein 1. (1103 aa) |
| | TOP3B | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (255 aa) |
| | EXO1 | Exonuclease 1. (836 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (405 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (196 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (272 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (286 aa) |
| | RAD51C | RAD51 paralog C. (379 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1243 aa) |
| | RADX | RPA1 related single stranded DNA binding protein, X-linked. (862 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (909 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (989 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (349 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (281 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (902 aa) |
| | RMI2 | RecQ mediated genome instability 2. (156 aa) |
| | CETN2 | Uncharacterized protein. (172 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1754 aa) |
| | NTHL1 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (336 aa) |
| | FANCA | FA complementation group A. (1448 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (769 aa) |
| | PIEZO1 | Piezo-type mechanosensitive ion channel component. (2638 aa) |
| | TERF2IP | TERF2 interacting protein. (403 aa) |
| | CDC7 | Cell division cycle 7. (576 aa) |
| | PRIM2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (509 aa) |
| | HELB | DNA helicase B. (1135 aa) |
| | TDRD3 | Tudor domain containing 3. (648 aa) |
| | ACD | ACD shelterin complex subunit and telomerase recruitment factor. (455 aa) |
| | LOC606761 | zf-4CXXC_R1 domain-containing protein. (407 aa) |
| | MGMT | Methylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated; Belongs to the MGMT family. (210 aa) |
| | TINF2 | TERF1 interacting nuclear factor 2. (452 aa) |
| | POLN | DNA polymerase nu. (899 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | SMUG1 | Single-strand-selective monofunctional uracil-DNA glycosylase 1. (299 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (810 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1825 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1355 aa) |
| | NBN | Nibrin. (886 aa) |
| | GINS1 | GINS complex subunit 1. (196 aa) |
| | RCHY1 | Ring finger and CHY zinc finger domain containing 1. (259 aa) |
| | HELQ | Helicase, POLQ like. (1072 aa) |
| | TEN1 | TEN1 subunit of CST complex. (121 aa) |
| | J9P2V5_CANLF | Uncharacterized protein. (599 aa) |
| | FANCD2 | FA complementation group D2. (1471 aa) |
| | FANCF | FA complementation group F. (494 aa) |
| | FAAP20 | FANCA_interact domain-containing protein. (196 aa) |
| | RAD50 | RAD50 double strand break repair protein. (1312 aa) |
| | UBQLNL | Ubiquilin like. (583 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1275 aa) |
| | FANCM | FA complementation group M. (2047 aa) |
| | NEIL3 | Nei like DNA glycosylase 3. (604 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (933 aa) |
| | CHTF8 | Chromosome transmission fidelity factor 8. (121 aa) |
| | STN1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (369 aa) |
| | APEX1 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (460 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | ENSCAFP00000043611 | Uncharacterized protein. (109 aa) |
| | FANCC | FA complementation group C. (749 aa) |
| | FANCL | FA complementation group L. (412 aa) |
| | ORC2 | Origin recognition complex subunit 2. (610 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (864 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (803 aa) |
| | POLE4 | CBFD_NFYB_HMF domain-containing protein. (275 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1921 aa) |
| | TIMELESS | Timeless circadian regulator. (1297 aa) |
| | GINS2 | GINS complex subunit 2. (198 aa) |
| | TERF2 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (540 aa) |
| | MCM5 | Minichromosome maintenance complex component 5; Belongs to the MCM family. (689 aa) |
| | RFC2 | Replication factor C subunit 2. (367 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3121 aa) |
| | POLE2 | DNA polymerase epsilon 2, accessory subunit. (640 aa) |
| | CTC1 | CST telomere replication complex component 1. (1236 aa) |
| | OGG1 | 8-oxoguanine DNA glycosylase. (344 aa) |
| | AFF3 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1346 aa) |
| | ENSCAFP00000053494 | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (258 aa) |
| | RAD23A | RAD23 homolog A, nucleotide excision repair protein. (528 aa) |
| | MUTYH | MutY DNA glycosylase. (729 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2335 aa) |
| | RPA3 | Uncharacterized protein. (351 aa) |
| | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (438 aa) |
| | RAD51B | RAD51 paralog B. (350 aa) |
| | FANCI | FA complementation group I. (1404 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1416 aa) |
| | RAD51 | DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Part of a PALB2-scaffolded HR [...] (317 aa) |
| | LIG3 | DNA ligase. (991 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (585 aa) |
| | UVSSA | UV stimulated scaffold protein A. (719 aa) |
| | PMS1 | PMS1 homolog 1, mismatch repair system component. (930 aa) |
| | MCM8 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (848 aa) |
| | POLD3 | DNA polymerase delta 3, accessory subunit. (541 aa) |
| | RPA2 | Replication protein A2. (390 aa) |
| | CHTF18 | Chromosome transmission fidelity factor 18. (1107 aa) |
| | PMS2 | PMS1 homolog 2, mismatch repair system component. (1571 aa) |
| | ENSCAFP00000062039 | Uncharacterized protein. (273 aa) |
| | RFC1 | Replication factor C subunit 1. (1198 aa) |
| | XRCC1 | Uncharacterized protein. (664 aa) |
| | ORC4 | Origin recognition complex subunit 4. (581 aa) |
| | ORC6 | Origin recognition complex subunit 6. (395 aa) |
| | UNG | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (298 aa) |
| | HUS1 | HUS1 checkpoint clamp component. (420 aa) |
| | NEIL1 | Nei like DNA glycosylase 1. (519 aa) |
| | FAAP24 | FA core complex associated protein 24. (253 aa) |
| | LIG1 | DNA ligase. (915 aa) |
