STRINGSTRING
RUVBL2 RUVBL2 RPA1 RPA1 ERCC4 ERCC4 FBXO4 FBXO4 XRCC3 XRCC3 RAD51C RAD51C SLX1A SLX1A INO80E INO80E UPF1 UPF1 E2RCP4_CANLF E2RCP4_CANLF DNA2 DNA2 INO80D INO80D ZNF365 ZNF365 BLM BLM GAR1 GAR1 DCLRE1A DCLRE1A LTO1 LTO1 UCHL5 UCHL5 NFRKB NFRKB PARP3 PARP3 INO80 INO80 CCNE2 CCNE2 DCLRE1B DCLRE1B ACTR8 ACTR8 PINX1 PINX1 TERF1 TERF1 ATR ATR CCNE1 CCNE1 PRKDC PRKDC WRN WRN BRCA2 BRCA2 PCNA PCNA RIF1 RIF1 ERCC1 ERCC1 MRE11 MRE11 RUVBL1 RUVBL1 SLX4 SLX4 RPS9 RPS9 ZSCAN4 ZSCAN4 POT1 POT1 HUS1 HUS1 XRCC1 XRCC1 NHP2 NHP2 ENSCAFP00000062039 ENSCAFP00000062039 RAD51 RAD51 XRCC6 XRCC6 DCLRE1C DCLRE1C SMC6 SMC6 EFNB3 EFNB3 CTC1 CTC1 ENSCAFP00000050766 ENSCAFP00000050766 TERF2 TERF2 TEP1 TEP1 TERT TERT ZNF827 ZNF827 NSMCE2 NSMCE2 APEX1 APEX1 STN1 STN1 SMC5 SMC5 MCRS1 MCRS1 RAD50 RAD50 TELO2 TELO2 XRCC5 XRCC5 NBN NBN ATM ATM TINF2 TINF2 ACD ACD TERF2IP TERF2IP DKC1 DKC1 ZBTB48 ZBTB48
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (902 aa)
FBXO4F-box protein 4. (387 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (349 aa)
RAD51CRAD51 paralog C. (379 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (272 aa)
INO80EINO80 complex subunit E. (244 aa)
UPF1UPF1 RNA helicase and ATPase. (1130 aa)
E2RCP4_CANLFUncharacterized protein. (431 aa)
DNA2DNA replication helicase/nuclease 2. (1017 aa)
INO80DINO80 complex subunit D. (1029 aa)
ZNF365Zinc finger protein 365. (408 aa)
BLMBLM RecQ like helicase. (1420 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (210 aa)
DCLRE1ADNA cross-link repair 1A. (1049 aa)
LTO1LTO1 maturation factor of ABCE1. (261 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (328 aa)
NFRKBNuclear factor related to kappaB binding protein. (1311 aa)
PARP3Poly [ADP-ribose] polymerase. (531 aa)
INO80INO80 complex ATPase subunit. (1560 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (399 aa)
DCLRE1BDNA cross-link repair 1B. (530 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (423 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (431 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (373 aa)
PRKDCDNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act [...] (4067 aa)
WRNWRN RecQ like helicase. (1574 aa)
BRCA2BRCA2 DNA repair associated. (3446 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
RIF1Replication timing regulatory factor 1. (2549 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (314 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1754 aa)
RPS9TCF3 fusion partner. (253 aa)
ZSCAN4Uncharacterized protein. (437 aa)
POT1Protection of telomeres 1. (785 aa)
HUS1HUS1 checkpoint clamp component. (420 aa)
XRCC1Uncharacterized protein. (664 aa)
NHP2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (228 aa)
ENSCAFP00000062039Uncharacterized protein. (273 aa)
RAD51DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Part of a PALB2-scaffolded HR [...] (317 aa)
XRCC6X-ray repair cross complementing 6. (612 aa)
DCLRE1CDNA cross-link repair 1C. (715 aa)
SMC6Structural maintenance of chromosomes 6. (1156 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (798 aa)
CTC1CST telomere replication complex component 1. (1236 aa)
ENSCAFP00000050766G-patch domain-containing protein. (280 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (540 aa)
TEP1Telomerase associated protein 1. (2632 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1253 aa)
ZNF827Zinc finger protein 827. (1347 aa)
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (265 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (460 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (369 aa)
SMC5Structural maintenance of chromosomes 5. (1106 aa)
MCRS1Microspherule protein 1. (518 aa)
RAD50RAD50 double strand break repair protein. (1312 aa)
TELO2Telomere maintenance 2. (844 aa)
XRCC5X-ray repair cross complementing 5. (829 aa)
NBNNibrin. (886 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
TINF2TERF1 interacting nuclear factor 2. (452 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (455 aa)
TERF2IPTERF2 interacting protein. (403 aa)
DKC1Dyskerin pseudouridine synthase 1. (683 aa)
ZBTB48Zinc finger and BTB domain containing 48. (688 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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