STRINGSTRING
POLR2B POLR2B ORC4 ORC4 DOT1L DOT1L XRCC1 XRCC1 ENSCAFP00000062039 ENSCAFP00000062039 LRWD1 LRWD1 CDK2 CDK2 RAD51 RAD51 SMCHD1 SMCHD1 ENSCAFP00000058271 ENSCAFP00000058271 SMC6 SMC6 EFNB3 EFNB3 RNF8 RNF8 KDM1A KDM1A THOC6 THOC6 ENSCAFP00000052503 ENSCAFP00000052503 CTC1 CTC1 ENSCAFP00000050766 ENSCAFP00000050766 TERF2 TERF2 RBBP4 RBBP4 PML PML TERT TERT ZNF827 ZNF827 ORC1 ORC1 GALK1 GALK1 NSMCE2 NSMCE2 ORC2 ORC2 FEN1 FEN1 STN1 STN1 NABP1 NABP1 SMC5 SMC5 SUN2 SUN2 RAD50 RAD50 TEN1 TEN1 SIRT6 SIRT6 XRCC5 XRCC5 NBN NBN NABP2 NABP2 EZH2 EZH2 ATM ATM TINF2 TINF2 ACD ACD THOC7 THOC7 TERB1 TERB1 TERF2IP TERF2IP LRIF1 LRIF1 ZBTB48 ZBTB48 SLX4 SLX4 ERCC4 ERCC4 THOC1 THOC1 NSMCE1 NSMCE1 GATAD2B GATAD2B ATRX ATRX MTA2 MTA2 CHD4 CHD4 UPF1 UPF1 THOC3 THOC3 E2RCP4_CANLF E2RCP4_CANLF DNA2 DNA2 TERB2 TERB2 HAT1 HAT1 RBBP7 RBBP7 TP53BP1 TP53BP1 NSMCE4A NSMCE4A BLM BLM THOC5 THOC5 RAE1 RAE1 TFIP11 TFIP11 GAR1 GAR1 CHEK1 CHEK1 DCLRE1B DCLRE1B WRNIP1 WRNIP1 DHX36 DHX36 ZBTB10 ZBTB10 PINX1 PINX1 TERF1 TERF1 RAD17 RAD17 TNKS TNKS CBX5 CBX5 WRN WRN BRCA2 BRCA2 RIF1 RIF1 TOX4 TOX4 ERCC1 ERCC1 MRE11 MRE11 CCDC155 CCDC155 POLD1 POLD1 ZSCAN4 ZSCAN4 POT1 POT1 DMC1 DMC1 PPP1R10 PPP1R10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1325 aa)
ORC4Origin recognition complex subunit 4. (581 aa)
DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specific. (1735 aa)
XRCC1Uncharacterized protein. (664 aa)
ENSCAFP00000062039Uncharacterized protein. (273 aa)
LRWD1Leucine rich repeats and WD repeat domain containing 1. (716 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
RAD51DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Part of a PALB2-scaffolded HR [...] (317 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (3051 aa)
ENSCAFP00000058271WD_REPEATS_REGION domain-containing protein. (409 aa)
SMC6Structural maintenance of chromosomes 6. (1156 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (798 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (736 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (877 aa)
THOC6THO complex 6. (371 aa)
ENSCAFP00000052503WD_REPEATS_REGION domain-containing protein. (327 aa)
CTC1CST telomere replication complex component 1. (1236 aa)
ENSCAFP00000050766G-patch domain-containing protein. (280 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (540 aa)
RBBP4RB binding protein 4, chromatin remodeling factor. (430 aa)
PMLPromyelocytic leukemia. (933 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1253 aa)
ZNF827Zinc finger protein 827. (1347 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (864 aa)
GALK1Galactokinase; Major enzyme for galactose metabolism; Belongs to the GHMP kinase family. GalK subfamily. (431 aa)
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (265 aa)
ORC2Origin recognition complex subunit 2. (610 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (369 aa)
NABP1Nucleic acid binding protein 1. (124 aa)
SMC5Structural maintenance of chromosomes 5. (1106 aa)
SUN2Sad1 and UNC84 domain containing 2. (725 aa)
RAD50RAD50 double strand break repair protein. (1312 aa)
TEN1TEN1 subunit of CST complex. (121 aa)
SIRT6Sirtuin 6. (403 aa)
XRCC5X-ray repair cross complementing 5. (829 aa)
NBNNibrin. (886 aa)
NABP2Nucleic acid binding protein 2. (280 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (842 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
TINF2TERF1 interacting nuclear factor 2. (452 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (455 aa)
THOC7THO complex 7. (234 aa)
TERB1Telomere repeat binding bouquet formation protein 1. (721 aa)
TERF2IPTERF2 interacting protein. (403 aa)
LRIF1Ligand dependent nuclear receptor interacting factor 1. (757 aa)
ZBTB48Zinc finger and BTB domain containing 48. (688 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1754 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (902 aa)
THOC1THO complex 1. (657 aa)
NSMCE1NSE1 homolog, SMC5-SMC6 complex component. (283 aa)
GATAD2BGATA zinc finger domain containing 2B. (610 aa)
ATRXATRX chromatin remodeler. (2489 aa)
MTA2Metastasis associated 1 family member 2. (668 aa)
CHD4Chromodomain helicase DNA binding protein 4. (1984 aa)
UPF1UPF1 RNA helicase and ATPase. (1130 aa)
THOC3THO complex 3. (355 aa)
E2RCP4_CANLFUncharacterized protein. (431 aa)
DNA2DNA replication helicase/nuclease 2. (1017 aa)
TERB2Telomere repeat binding bouquet formation protein 2. (221 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (469 aa)
TP53BP1Tumor protein p53 binding protein 1. (1936 aa)
NSMCE4ANon-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (161 aa)
BLMBLM RecQ like helicase. (1420 aa)
THOC5THO complex 5. (719 aa)
RAE1SPO11 initiator of meiotic double stranded breaks. (396 aa)
TFIP11Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] (837 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (210 aa)
CHEK1Checkpoint kinase 1. (454 aa)
DCLRE1BDNA cross-link repair 1B. (530 aa)
WRNIP1Werner helicase interacting protein 1. (445 aa)
DHX36DEAH-box helicase 36. (1122 aa)
ZBTB10Zinc finger and BTB domain containing 10. (634 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (423 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (431 aa)
RAD17RAD17 checkpoint clamp loader component. (680 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
CBX5Chromobox 5. (191 aa)
WRNWRN RecQ like helicase. (1574 aa)
BRCA2BRCA2 DNA repair associated. (3446 aa)
RIF1Replication timing regulatory factor 1. (2549 aa)
TOX4TOX high mobility group box family member 4. (594 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (314 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
CCDC155Coiled-coil domain containing 155. (566 aa)
POLD1DNA polymerase. (1107 aa)
ZSCAN4Uncharacterized protein. (437 aa)
POT1Protection of telomeres 1. (785 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa)
PPP1R10Protein phosphatase 1 regulatory subunit 10. (940 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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