(38 nodes) Heart looping network (Canis lupus familiaris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AHI1	Abelson helper integration site 1. (1178 aa)
	FOXH1	Forkhead box H1. (399 aa)
	SRF	Serum response factor. (508 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (689 aa)
	GAA	Glucosidase alpha, acid. (1187 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (256 aa)
	MICAL2	Microtubule associated monooxygenase, calponin and LIM domain containing 2. (1948 aa)
	ARL13B	ADP ribosylation factor like GTPase 13B. (430 aa)
	IFT52	Intraflagellar transport 52. (446 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (874 aa)
	IFT57	Intraflagellar transport 57. (482 aa)
	SUFU	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
	NOTCH2	Notch receptor 2. (2726 aa)
	CCDC103	Coiled-coil domain containing 103. (242 aa)
	TBX6	T-box transcription factor 6. (436 aa)
	SMAD3	Mothers against decapentaplegic homolog. (611 aa)
	ASB2	Ankyrin repeat and SOCS box containing 2. (630 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (218 aa)
	ZIC3	Zic family member 3. (466 aa)
	NOTCH1	Notch receptor 1. (2565 aa)
	DNAAF1	Dynein assembly factor 1, axonemal. (639 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (398 aa)
	TBX20	T-box transcription factor 20. (448 aa)
	TBX2	T-box transcription factor TBX2; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be Required for cardiac atrioventricular canal formation (By similarity). (655 aa)
	SOX17	SRY-box 17. (418 aa)
	MIB1	Mindbomb E3 ubiquitin protein ligase 1. (939 aa)
	NODAL	Nodal growth differentiation factor. (378 aa)
	LBX1	Ladybird homeobox 1. (281 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	MESP1	Mesoderm posterior bHLH transcription factor 1. (265 aa)
	ENG	Endoglin. (652 aa)
	TBX3	T-box transcription factor 3. (720 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (593 aa)
	CLUAP1	Clusterin associated protein 1. (498 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (760 aa)
	HIF1A	Uncharacterized protein. (823 aa)
	NPHP3	Nephrocystin 3. (1378 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHI1	ARL13B	ENSCAFP00000000339	ENSCAFP00000013262	Abelson helper integration site 1.	ADP ribosylation factor like GTPase 13B.	0.600
AHI1	NPHP3	ENSCAFP00000000339	ENSCAFP00000066560	Abelson helper integration site 1.	Nephrocystin 3.	0.656
ARL13B	AHI1	ENSCAFP00000013262	ENSCAFP00000000339	ADP ribosylation factor like GTPase 13B.	Abelson helper integration site 1.	0.600
ARL13B	IFT52	ENSCAFP00000013262	ENSCAFP00000013725	ADP ribosylation factor like GTPase 13B.	Intraflagellar transport 52.	0.739
ARL13B	IFT57	ENSCAFP00000013262	ENSCAFP00000014569	ADP ribosylation factor like GTPase 13B.	Intraflagellar transport 57.	0.752
ARL13B	NPHP3	ENSCAFP00000013262	ENSCAFP00000066560	ADP ribosylation factor like GTPase 13B.	Nephrocystin 3.	0.751
ARL13B	PKD2	ENSCAFP00000013262	ENSCAFP00000014105	ADP ribosylation factor like GTPase 13B.	Polycystin 2, transient receptor potential cation channel.	0.790
ARL13B	SHH	ENSCAFP00000013262	ENSCAFP00000050657	ADP ribosylation factor like GTPase 13B.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.736
ARL13B	SMO	ENSCAFP00000013262	ENSCAFP00000060116	ADP ribosylation factor like GTPase 13B.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.846
ARL13B	SUFU	ENSCAFP00000013262	ENSCAFP00000015018	ADP ribosylation factor like GTPase 13B.	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	0.477
CCDC103	DNAAF1	ENSCAFP00000020601	ENSCAFP00000029580	Coiled-coil domain containing 103.	Dynein assembly factor 1, axonemal.	0.808
CCDC103	GAA	ENSCAFP00000020601	ENSCAFP00000008338	Coiled-coil domain containing 103.	Glucosidase alpha, acid.	0.880
CITED2	HIF1A	ENSCAFP00000035991	ENSCAFP00000064837	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2.	Uncharacterized protein.	0.616
CLUAP1	IFT52	ENSCAFP00000052203	ENSCAFP00000013725	Clusterin associated protein 1.	Intraflagellar transport 52.	0.982
CLUAP1	IFT57	ENSCAFP00000052203	ENSCAFP00000014569	Clusterin associated protein 1.	Intraflagellar transport 57.	0.989
DLL1	MIB1	ENSCAFP00000006075	ENSCAFP00000037904	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mindbomb E3 ubiquitin protein ligase 1.	0.415
DLL1	NOTCH1	ENSCAFP00000006075	ENSCAFP00000029073	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.996
DLL1	NOTCH2	ENSCAFP00000006075	ENSCAFP00000015629	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 2.	0.986
DNAAF1	CCDC103	ENSCAFP00000029580	ENSCAFP00000020601	Dynein assembly factor 1, axonemal.	Coiled-coil domain containing 103.	0.808
DNAAF1	GAA	ENSCAFP00000029580	ENSCAFP00000008338	Dynein assembly factor 1, axonemal.	Glucosidase alpha, acid.	0.745