STRINGSTRING
ARHGAP24 ARHGAP24 ARHGAP35 ARHGAP35 RHOB RHOB TBX20 TBX20 FLRT3 FLRT3 E2RLH2_CANLF E2RLH2_CANLF RHOA RHOA CCN1 CCN1 TOR1A TOR1A NOTCH1 NOTCH1 FLNA FLNA DVL1 DVL1 LRG1 LRG1 LAMA1 LAMA1 HOXB2 HOXB2 PDPN PDPN MPP5 MPP5 DVL2 DVL2 PDCD10 PDCD10 DAG1 DAG1 NOTCH2 NOTCH2 LIN7C LIN7C TMEFF2 TMEFF2 DLL4 DLL4 ITGA5 ITGA5 SOS1 SOS1 JAG1 JAG1 MEGF8 MEGF8 ARHGAP12 ARHGAP12 SRF SRF DDR1 DDR1 HOXB4 HOXB4 RHOC RHOC PLET1 PLET1 ENSCAFP00000053930 ENSCAFP00000053930 HBEGF HBEGF CD44 CD44 PHACTR4 PHACTR4 ACVRL1 ACVRL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARHGAP24Rho GTPase activating protein 24. (753 aa)
ARHGAP35Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase- activating protein [...] (1516 aa)
RHOBRas homolog family member B. (199 aa)
TBX20T-box transcription factor 20. (448 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
E2RLH2_CANLFUncharacterized protein. (198 aa)
RHOATransforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (193 aa)
CCN1Cellular communication network factor 1. (385 aa)
TOR1ATorsin. (332 aa)
NOTCH1Notch receptor 1. (2565 aa)
FLNAFilamin A. (2646 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (354 aa)
LAMA1Laminin subunit alpha 1. (3034 aa)
HOXB2Homeobox B2. (342 aa)
PDPNPodoplanin; Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation. Interaction with CD9, on the contrary, attenuates platelet aggregation and pulmonary metastasis induced by PDPN. Mediates effects on cell migration and adhesion through its different partners. Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and tr [...] (192 aa)
MPP5MAGUK p55 subfamily member 5; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells. Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface. Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (By similarity). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebell [...] (675 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
PDCD10Programmed cell death 10. (212 aa)
DAG1Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...] (892 aa)
NOTCH2Notch receptor 2. (2726 aa)
LIN7CProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (197 aa)
TMEFF2Transmembrane protein with EGF like and two follistatin like domains 2. (374 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (732 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1053 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1353 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
MEGF8Multiple EGF like domains 8. (439 aa)
ARHGAP12Rho GTPase activating protein 12. (897 aa)
SRFSerum response factor. (508 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (984 aa)
HOXB4Homeobox B4. (289 aa)
RHOCUncharacterized protein. (229 aa)
PLET1Uncharacterized protein. (277 aa)
ENSCAFP00000053930Uncharacterized protein. (183 aa)
HBEGFHeparin binding EGF like growth factor. (263 aa)
CD44CD44 antigen. (859 aa)
PHACTR4Phosphatase and actin regulator. (732 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (581 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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