STRINGSTRING
TOMM70 TOMM70 SYK SYK TBK1 TBK1 ENSCAFP00000049310 ENSCAFP00000049310 PTPN9 PTPN9 FCN1 FCN1 HMGB1 HMGB1 XRCC5 XRCC5 CASP6 CASP6 KLRD1 KLRD1 KLRK1 KLRK1 HEXIM1 HEXIM1 TLR9-2 TLR9-2 PLCG2 PLCG2 PYCARD PYCARD LOC610648 LOC610648 MNDA MNDA LOC488622 LOC488622 ZNFX1 ZNFX1 XRCC6 XRCC6 PSPC1 PSPC1 FFAR2 FFAR2 CGAS CGAS PQBP1 PQBP1 MATR3 MATR3 SFPQ SFPQ STING1 STING1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TOMM70Translocase of outer mitochondrial membrane 70. (609 aa)
SYKTyrosine-protein kinase. (699 aa)
TBK1TANK binding kinase 1. (772 aa)
ENSCAFP00000049310Uncharacterized protein. (176 aa)
PTPN9SIN3 transcription regulator family member A. (1303 aa)
FCN1Ficolin 1. (322 aa)
HMGB1High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (240 aa)
XRCC5X-ray repair cross complementing 5. (829 aa)
CASP6Caspase 6; Belongs to the peptidase C14A family. (497 aa)
KLRD1Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. (179 aa)
KLRK1Killer cell lectin like receptor K1. (217 aa)
HEXIM1HEXIM P-TEFb complex subunit 1. (229 aa)
TLR9-2Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1032 aa)
PLCG2Phosphoinositide phospholipase C. (1336 aa)
PYCARDPYD and CARD domain containing. (195 aa)
LOC610648RNA binding motif protein 14. (620 aa)
MNDAMyeloid cell nuclear differentiation antigen. (507 aa)
LOC488622Uncharacterized protein. (534 aa)
ZNFX1Zinc finger NFX1-type containing 1. (1918 aa)
XRCC6X-ray repair cross complementing 6. (612 aa)
PSPC1Paraspeckle component 1. (505 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (331 aa)
CGASCyclic GMP-AMP synthase. (501 aa)
PQBP1Polyglutamine binding protein 1. (358 aa)
MATR3Uncharacterized protein. (864 aa)
SFPQSplicing factor proline and glutamine rich. (702 aa)
STING1Transmembrane protein 173. (375 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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