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HNRNPU HNRNPU NHP2 NHP2 SMG5 SMG5 ENSCAFP00000054853 ENSCAFP00000054853 EFNB3 EFNB3 TEP1 TEP1 TERT TERT NVL NVL NOP10 NOP10 NAT10 NAT10 GAR1 GAR1 SMG7 SMG7 ACD ACD DKC1 DKC1 SMG6 SMG6 TSR2 TSR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (805 aa)
NHP2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (228 aa)
SMG5SMG5 nonsense mediated mRNA decay factor. (1046 aa)
ENSCAFP00000054853Uncharacterized protein. (217 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (798 aa)
TEP1Telomerase associated protein 1. (2632 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1253 aa)
NVLNuclear VCP like. (855 aa)
NOP10NOP10 ribonucleoprotein. (64 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1025 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (210 aa)
SMG7SMG7 nonsense mediated mRNA decay factor. (1179 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (455 aa)
DKC1Dyskerin pseudouridine synthase 1. (683 aa)
SMG6SMG6 nonsense mediated mRNA decay factor. (1412 aa)
TSR2G protein nucleolar 3 like. (649 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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