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TRMT1L TRMT1L LOC608513 LOC608513 LYRM9 LYRM9 TRMT10A TRMT10A TRMU TRMU ELP6 ELP6 METTL8 METTL8 WDR6 WDR6 DALRD3 DALRD3 TRUB1 TRUB1 MOCS3 MOCS3 LOC479708 LOC479708 TYW5 TYW5 QTRT2 QTRT2 PUS3 PUS3 WDR4 WDR4 NSUN2 NSUN2 OSGEPL1 OSGEPL1 NSUN3 NSUN3 BCDIN3D BCDIN3D ELP3 ELP3 ELP4 ELP4 NAT10 NAT10 TRMT9B TRMT9B THUMPD2 THUMPD2 TRMT6 TRMT6 DPH3 DPH3 ANKRD16 ANKRD16 TRDMT1 TRDMT1 NSUN6 NSUN6 PUS7 PUS7 DUS4L DUS4L KTI12 KTI12 PUS10 PUS10 CTU1 CTU1 MTO1 MTO1 TSTD2 TSTD2 AARS2 AARS2 C1H9orf64 C1H9orf64 DTWD2 DTWD2 GTPBP3 GTPBP3 ELP5 ELP5 HSD17B10 HSD17B10 MTFMT MTFMT ALKBH1 ALKBH1 THG1L THG1L QTRT1 QTRT1 THUMPD1 THUMPD1 DUS3L DUS3L CTU2 CTU2 TRMT13 TRMT13 AARS1 AARS1 DUS2 DUS2 THUMPD3 THUMPD3 RPUSD4 RPUSD4 E2RRU8_CANLF E2RRU8_CANLF CDK5RAP1 CDK5RAP1 F6XPR6_CANLF F6XPR6_CANLF PUS1 PUS1 TRMT10B TRMT10B TRMT61A TRMT61A GON7 GON7 DUS1L DUS1L TRMT10C TRMT10C TRMT5 TRMT5 TRMT61B TRMT61B OSGEP OSGEP URM1 URM1 METTL1 METTL1 YRDC YRDC GTPBP6 GTPBP6 PUSL1 PUSL1 TRMT11 TRMT11 TRIT1 TRIT1 THADA THADA ADAT2 ADAT2 ELP2 ELP2 ELP1 ELP1 TRMT1 TRMT1 TYW3 TYW3 J9P8X0_CANLF J9P8X0_CANLF TARBP1 TARBP1 TRMO TRMO LOC100684019 LOC100684019 METTL2A METTL2A FTSJ1 FTSJ1 DTWD1 DTWD1 TRMT44 TRMT44 TRMT112 TRMT112 TRMT2A TRMT2A CDKAL1 CDKAL1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRMT1LtRNA methyltransferase 1 like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (749 aa)
LOC608513CheR domain-containing protein. (301 aa)
LYRM9Uncharacterized protein; Belongs to the complex I LYR family. (86 aa)
TRMT10AtRNA methyltransferase 10A. (409 aa)
TRMUtRNA 5-methylaminomethyl-2-thiouridylate methyltransferase. (485 aa)
ELP6Elongator acetyltransferase complex subunit 6. (297 aa)
METTL8Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (414 aa)
WDR6WD repeat domain 6. (1119 aa)
DALRD3DALR anticodon binding domain containing 3. (542 aa)
TRUB1TruB pseudouridine synthase family member 1. (350 aa)
MOCS3Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] (498 aa)
LOC479708Flavodoxin-like domain-containing protein. (714 aa)
TYW5tRNA-yW synthesizing protein 5. (315 aa)
QTRT2Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily. (433 aa)
PUS3Pseudouridine synthase 3. (480 aa)
WDR4tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family. (406 aa)
NSUN2NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (780 aa)
OSGEPL1Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. (414 aa)
NSUN3NOP2/Sun RNA methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (334 aa)
BCDIN3DBCDIN3 domain containing RNA methyltransferase. (353 aa)
ELP3Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (524 aa)
ELP4Elongator acetyltransferase complex subunit 4. (479 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1025 aa)
TRMT9BtRNA methyltransferase 9B (putative). (453 aa)
THUMPD2THUMP domain containing 2. (502 aa)
TRMT6tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N1-)- methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. (497 aa)
DPH3Diphthamide biosynthesis 3. (82 aa)
ANKRD16Ankyrin repeat domain 16. (359 aa)
TRDMT1tRNA aspartic acid methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (391 aa)
NSUN6NOP2/Sun RNA methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (469 aa)
PUS7Pseudouridine synthase 7. (695 aa)
DUS4LtRNA-dihydrouridine synthase; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the dus family. (317 aa)
KTI12KTI12 chromatin associated homolog. (339 aa)
PUS10Pseudouridine synthase 10. (532 aa)
CTU1ATP_bind_3 domain-containing protein. (181 aa)
MTO1Mitochondrial tRNA translation optimization 1. (672 aa)
TSTD2Thiosulfate sulfurtransferase like domain containing 2. (526 aa)
AARS2Alanyl-tRNA synthetase 2, mitochondrial; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (985 aa)
C1H9orf64Queuosine salvage protein; Involved in salvaging queuosine. (341 aa)
DTWD2DTW domain-containing protein. (232 aa)
GTPBP3GTP binding protein 3, mitochondrial. (492 aa)
ELP5Elongator acetyltransferase complex subunit 5. (315 aa)
HSD17B10Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa)
MTFMTMitochondrial methionyl-tRNA formyltransferase. (458 aa)
ALKBH1AlkB homolog 1, histone H2A dioxygenase. (389 aa)
THG1LtRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. (298 aa)
QTRT1Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (403 aa)
THUMPD1THUMP domain containing 1. (358 aa)
DUS3LtRNA-dihydrouridine(47) synthase [NAD(P)(+)]. (645 aa)
CTU2Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Belongs to the CTU2/NCS2 family. (515 aa)
TRMT13tRNA methyltransferase 13 homolog. (450 aa)
AARS1Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
DUS2Dihydrouridine synthase 2. (493 aa)
THUMPD3THUMP domain-containing protein. (503 aa)
RPUSD4RNA pseudouridine synthase D4. (388 aa)
E2RRU8_CANLFATP_bind_3 domain-containing protein. (284 aa)
CDK5RAP1CDK5 regulatory subunit associated protein 1. (583 aa)
F6XPR6_CANLFTHUMP domain-containing protein. (474 aa)
PUS1Pseudouridine synthase 1. (561 aa)
TRMT10BtRNA methyltransferase 10B. (316 aa)
TRMT61AtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. (289 aa)
GON7GON7 subunit of KEOPS complex. (100 aa)
DUS1LDihydrouridine synthase 1 like. (560 aa)
TRMT10CtRNA methyltransferase 10C, mitochondrial RNase P subunit. (440 aa)
TRMT5tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family. (495 aa)
TRMT61BtRNA methyltransferase 61B. (486 aa)
OSGEPProbable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. (354 aa)
URM1Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for co [...] (139 aa)
METTL1tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (259 aa)
YRDCYrdC N6-threonylcarbamoyltransferase domain containing. (517 aa)
GTPBP6GTP binding protein 6 (putative). (718 aa)
PUSL1Pseudouridine synthase like 1. (564 aa)
TRMT11tRNA methyltransferase 11 homolog. (579 aa)
TRIT1tRNA isopentenyltransferase 1; Belongs to the IPP transferase family. (474 aa)
THADAThyroid adenoma-associated protein homolog; Belongs to the THADA family. (1951 aa)
ADAT2Adenosine deaminase tRNA specific 2. (228 aa)
ELP2Elongator acetyltransferase complex subunit 2. (1098 aa)
ELP1Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. (1337 aa)
TRMT1tRNA (guanine(26)-N(2))-dimethyltransferase. (659 aa)
TYW3tRNA-yW synthesizing protein 3 homolog. (139 aa)
J9P8X0_CANLFDTW domain-containing protein. (240 aa)
TARBP1TAR (HIV-1) RNA binding protein 1. (1633 aa)
TRMOtRNA methyltransferase O. (481 aa)
LOC100684019Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (273 aa)
METTL2AUncharacterized protein. (474 aa)
FTSJ1Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. (329 aa)
DTWD1DTW domain containing 1. (283 aa)
TRMT44C3H1-type domain-containing protein. (744 aa)
TRMT112tRNA methyltransferase subunit 11-2. (125 aa)
TRMT2AtRNA methyltransferase 2 homolog A; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (626 aa)
CDKAL1CDK5 regulatory subunit-associated protein 1-like 1. (578 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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