node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACD | DKC1 | ENSCAFP00000032488 | ENSCAFP00000029020 | ACD shelterin complex subunit and telomerase recruitment factor. | Dyskerin pseudouridine synthase 1. | 0.563 |
ACD | GAR1 | ENSCAFP00000032488 | ENSCAFP00000016895 | ACD shelterin complex subunit and telomerase recruitment factor. | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. | 0.542 |
ACD | NHP2 | ENSCAFP00000032488 | ENSCAFP00000063376 | ACD shelterin complex subunit and telomerase recruitment factor. | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. | 0.561 |
ACD | POT1 | ENSCAFP00000032488 | ENSCAFP00000002549 | ACD shelterin complex subunit and telomerase recruitment factor. | Protection of telomeres 1. | 0.994 |
ACD | RAD50 | ENSCAFP00000032488 | ENSCAFP00000040203 | ACD shelterin complex subunit and telomerase recruitment factor. | RAD50 double strand break repair protein. | 0.500 |
ACD | RPA1 | ENSCAFP00000032488 | ENSCAFP00000028391 | ACD shelterin complex subunit and telomerase recruitment factor. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.507 |
ACD | TERF1 | ENSCAFP00000032488 | ENSCAFP00000011804 | ACD shelterin complex subunit and telomerase recruitment factor. | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. | 0.915 |
ACD | TERT | ENSCAFP00000032488 | ENSCAFP00000048407 | ACD shelterin complex subunit and telomerase recruitment factor. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.837 |
DKC1 | ACD | ENSCAFP00000029020 | ENSCAFP00000032488 | Dyskerin pseudouridine synthase 1. | ACD shelterin complex subunit and telomerase recruitment factor. | 0.563 |
DKC1 | EFNB3 | ENSCAFP00000029020 | ENSCAFP00000053849 | Dyskerin pseudouridine synthase 1. | Ephrin B3; Belongs to the ephrin family. | 0.963 |
DKC1 | GAR1 | ENSCAFP00000029020 | ENSCAFP00000016895 | Dyskerin pseudouridine synthase 1. | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. | 0.999 |
DKC1 | NHP2 | ENSCAFP00000029020 | ENSCAFP00000063376 | Dyskerin pseudouridine synthase 1. | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. | 0.999 |
DKC1 | POT1 | ENSCAFP00000029020 | ENSCAFP00000002549 | Dyskerin pseudouridine synthase 1. | Protection of telomeres 1. | 0.653 |
DKC1 | TERF1 | ENSCAFP00000029020 | ENSCAFP00000011804 | Dyskerin pseudouridine synthase 1. | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. | 0.683 |
DKC1 | TERT | ENSCAFP00000029020 | ENSCAFP00000048407 | Dyskerin pseudouridine synthase 1. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.833 |
EFNB3 | DKC1 | ENSCAFP00000053849 | ENSCAFP00000029020 | Ephrin B3; Belongs to the ephrin family. | Dyskerin pseudouridine synthase 1. | 0.963 |
EFNB3 | GAR1 | ENSCAFP00000053849 | ENSCAFP00000016895 | Ephrin B3; Belongs to the ephrin family. | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. | 0.893 |
EFNB3 | NHP2 | ENSCAFP00000053849 | ENSCAFP00000063376 | Ephrin B3; Belongs to the ephrin family. | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. | 0.929 |
EFNB3 | TERT | ENSCAFP00000053849 | ENSCAFP00000048407 | Ephrin B3; Belongs to the ephrin family. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.589 |
ENSCAFP00000050766 | GAR1 | ENSCAFP00000050766 | ENSCAFP00000016895 | G-patch domain-containing protein. | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. | 0.449 |