STRINGSTRING
THBS1 THBS1 DHX36 DHX36 P2RX7 P2RX7 P2RX4 P2RX4 HESX1 HESX1 TRPC1 TRPC1 TRPA1 TRPA1 SLC30A5 SLC30A5 PAM PAM CAT CAT ERCC6 ERCC6 SMPD1 SMPD1 CPNE4 CPNE4 CYP1B1 CYP1B1 PRNP PRNP FOXO1 FOXO1 ADAM9 ADAM9 SYT1 SYT1 STK25 STK25 UCP3 UCP3 CPNE9 CPNE9 SELENOV SELENOV RPS3 RPS3 NET1 NET1 ITPKC ITPKC SPHK1 SPHK1 SCN5A SCN5A AXL AXL SLC6A1 SLC6A1 GSK3A GSK3A SLC30A3 SLC30A3 KHK KHK AOC1 AOC1 ATP7B ATP7B SELENOW SELENOW FKBP1B FKBP1B BRAF BRAF TRPV6 TRPV6 EGFR EGFR CAV1 CAV1 ZNF277 ZNF277 GPHN GPHN ENPP1 ENPP1 MAP3K5 MAP3K5 TNFAIP3 TNFAIP3 SLC30A8 SLC30A8 MAPK13 MAPK13 CER1 CER1 HSF1 HSF1 GUCA1A GUCA1A HMOX1 HMOX1 ANXA1 ANXA1 CCL19 CCL19 VCP VCP KDR KDR SLC25A13 SLC25A13 HAAO HAAO ALG2 ALG2 SYT3 SYT3 NT5E NT5E MTF1 MTF1 ALPL ALPL ADD1 ADD1 ENSCAFP00000065556 ENSCAFP00000065556 TJP1 TJP1 NCSTN NCSTN RASA4B RASA4B HIF1A HIF1A SOD3 SOD3 LRP11 LRP11 ALOX5AP ALOX5AP GLRX2 GLRX2 LOC111090444 LOC111090444 ADA ADA STK39 STK39 MAPK9 MAPK9 FABP4 FABP4 MT1E MT1E PARK7 PARK7 KDM6B KDM6B DLG4 DLG4 CARF CARF ENSCAFP00000060413 ENSCAFP00000060413 CACNA1H CACNA1H ENSCAFP00000059886 ENSCAFP00000059886 STIM1 STIM1 SLC25A12 SLC25A12 GUCY1B1 GUCY1B1 NEK7 NEK7 RAD51 RAD51 MNAT1 MNAT1 RNF112 RNF112 PRDX1 PRDX1 ENSCAFP00000056985 ENSCAFP00000056985 SYT2 SYT2 ENSCAFP00000056705 ENSCAFP00000056705 ZFAND1 ZFAND1 ENSCAFP00000056474 ENSCAFP00000056474 SLC41A1 SLC41A1 SELENOM SELENOM PTCH1 PTCH1 MEF2C MEF2C SYT6 SYT6 ENSCAFP00000052866 ENSCAFP00000052866 ENSCAFP00000052207 ENSCAFP00000052207 SYT5 SYT5 ENSCAFP00000051796 ENSCAFP00000051796 ANKH ANKH ENSCAFP00000051205 ENSCAFP00000051205 TFAP2A TFAP2A CPNE8 CPNE8 CPNE7 CPNE7 SYT9 SYT9 PRKAA1 PRKAA1 ATF1 ATF1 ENSCAFP00000050100 ENSCAFP00000050100 ECT2 ECT2 CPS1 CPS1 TREX1 TREX1 HDAC6 HDAC6 TIMELESS TIMELESS DAXX DAXX ANXA11 ANXA11 NQO1 NQO1 OSER1 OSER1 PIK3CA PIK3CA MAPK3-2 MAPK3-2 ATP2B4 ATP2B4 RIPK3 RIPK3 ENSCAFP00000047314 ENSCAFP00000047314 SLC25A23 SLC25A23 ENSCAFP00000047095 ENSCAFP00000047095 MEF2A MEF2A SLC30A10 SLC30A10 HFE HFE FBP1 FBP1 LOC474798 LOC474798 ZC3H12A ZC3H12A CPNE5 CPNE5 SRC SRC ENSCAFP00000044350 ENSCAFP00000044350 RTF2 RTF2 FANCC FANCC AQP1 AQP1 HVCN1 HVCN1 IMPACT IMPACT SOD2 SOD2 LOC489080 LOC489080 J9PB83_CANLF J9PB83_CANLF SPIDR SPIDR MT3 MT3 TRPC3 TRPC3 CCS CCS RUNX2 RUNX2 SLC38A2 SLC38A2 CYBRD1 CYBRD1 RASGRP2 RASGRP2 KCNJ10 KCNJ10 CUTA CUTA SIGMAR1 SIGMAR1 SYT17 SYT17 J9P7L3_CANLF J9P7L3_CANLF SLC30A1 SLC30A1 ACO1 ACO1 SELENOP SELENOP LOC100856408 LOC100856408 J9P3C7_CANLF J9P3C7_CANLF PPIF PPIF J9P228_CANLF J9P228_CANLF LOC100855763 LOC100855763 PEF1 PEF1 SLC30A2 SLC30A2 NFATC4 NFATC4 ZNF580 ZNF580 LOC100686507 LOC100686507 IL1A IL1A BMP6 BMP6 J9NWJ5_CANLF J9NWJ5_CANLF EZH2 EZH2 RASAL1 RASAL1 TIGAR TIGAR JUNB JUNB KCNMB3 KCNMB3 FXN FXN F1PSH3_CANLF F1PSH3_CANLF BAD BAD NFE2L2 NFE2L2 BNIP3 BNIP3 ACER1 ACER1 PRDX2 PRDX2 DDI1 DDI1 JUND JUND BAP1 BAP1 MAPK1 MAPK1 SMPD3 SMPD3 PLCG2 PLCG2 ABL1 ABL1 SETX SETX DPEP1 DPEP1 AHCYL1 AHCYL1 TRAF2 TRAF2 F1PXS7_CANLF F1PXS7_CANLF PRKAA2 PRKAA2 STK26 STK26 SLC1A3 SLC1A3 MAPK7 MAPK7 GLRA1 GLRA1 GRIA1 GRIA1 SYT4 SYT4 S100A16 S100A16 ATRX ATRX CACNA1G CACNA1G MAPK3 MAPK3 SYT11 SYT11 PCGF2 PCGF2 SLC34A1 SLC34A1 MIEN1 MIEN1 SYT7 SYT7 ITPKB ITPKB ALOX12 ALOX12 ATP13A2 ATP13A2 KCNMB2 KCNMB2 KCNMA1 KCNMA1 SLC13A5 SLC13A5 FGF23 FGF23 ANKZF1 ANKZF1 ABCB6 ABCB6 PDCD10 PDCD10 TXNRD2 TXNRD2 TFR2 TFR2 CRYAB CRYAB ADORA2A ADORA2A CREB1 CREB1 RELA RELA SIRT1 SIRT1 CDKN1B CDKN1B CLIC4 CLIC4 IQGAP1 IQGAP1 BLM BLM ADCY1 ADCY1 PRDX3 PRDX3 CAPN9 CAPN9 SLC18A2 SLC18A2 GLRA2 GLRA2 SYT12 SYT12 CASR CASR CPNE6 CPNE6 GPX1 GPX1 PDCD6 PDCD6 LGMN LGMN TCIRG1 TCIRG1 H9GWA7_CANLF H9GWA7_CANLF CAPN3 CAPN3 PPP3CA PPP3CA CRYAA CRYAA SYT10 SYT10 GPLD1 GPLD1 ADORA1 ADORA1 FIBIN FIBIN SYT8 SYT8 RYR2 RYR2 LRRK2 LRRK2 ADCY7 ADCY7 EDN1 EDN1 DMTN DMTN PPP1R15B PPP1R15B PKD2L1 PKD2L1 PKD2 PKD2 CHUK CHUK ITPKA ITPKA SYT13 SYT13 RIPK1 RIPK1 CRHBP CRHBP LOXL2 LOXL2 MT4 MT4 LOC100686073 LOC100686073 MT2A MT2A HOMER1 HOMER1 SLC12A3 SLC12A3 CPNE2 CPNE2 CPNE3 CPNE3 SOD1 SOD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
THBS1Thrombospondin 1. (1456 aa)
DHX36DEAH-box helicase 36. (1122 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
HESX1HESX homeobox 1. (186 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1118 aa)
SLC30A5Solute carrier family 30 member 5. (766 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (844 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells. (528 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1486 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (623 aa)
CPNE4Copine 4. (575 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...] (255 aa)
FOXO1Forkhead box O1. (654 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
SYT1Synaptotagmin 1. (422 aa)
STK25Protein kinase domain-containing protein. (426 aa)
UCP3Mitochondrial uncoupling protein 3; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family. (311 aa)
CPNE9Copine family member 9. (553 aa)
SELENOVUncharacterized protein. (424 aa)
RPS340S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8- dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] (243 aa)
NET1Neuroepithelial cell transforming 1. (658 aa)
ITPKCKinase; Belongs to the inositol phosphokinase (IPK) family. (659 aa)
SPHK1Sphingosine kinase 1. (487 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2013 aa)
AXLAXL receptor tyrosine kinase. (879 aa)
SLC6A1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (599 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (482 aa)
SLC30A3Solute carrier family 30 member 3. (388 aa)
KHKKetohexokinase. (300 aa)
AOC1Amine oxidase. (774 aa)
ATP7BATPase copper transporting beta. (1434 aa)
SELENOWSelenoprotein W. (87 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (772 aa)
TRPV6Transient receptor potential cation channel subfamily V member 6; Belongs to the transient receptor (TC 1.A.4) family. (764 aa)
EGFRReceptor protein-tyrosine kinase. (1141 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ZNF277Zinc finger protein 277. (483 aa)
GPHNGephyrin. (804 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (916 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1366 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
SLC30A8Solute carrier family 30 member 8. (369 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
CER1Cerberus 1, DAN family BMP antagonist. (264 aa)
HSF1Heat shock transcription factor 1. (554 aa)
GUCA1AGuanylate cyclase activator 1A. (205 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
ANXA1Annexin. (345 aa)
CCL19C-C motif chemokine. (115 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa)
SLC25A13Solute carrier family 25 member 13; Belongs to the mitochondrial carrier (TC 2.A.29) family. (676 aa)
HAAO3-hydroxyanthranilate 3,4-dioxygenase. (259 aa)
ALG2ALG2 alpha-1,3/1,6-mannosyltransferase. (416 aa)
SYT3Synaptotagmin 3. (591 aa)
NT5E5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (467 aa)
MTF1Metal regulatory transcription factor 1. (873 aa)
ALPLAlkaline phosphatase. (572 aa)
ADD1Adducin 1. (825 aa)
ENSCAFP00000065556Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (235 aa)
TJP1Tight junction protein ZO-1; TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation. Plays a role in the regulation [...] (1865 aa)
NCSTNNcstrn_small domain-containing protein. (708 aa)
RASA4BUncharacterized protein. (887 aa)
HIF1AUncharacterized protein. (823 aa)
SOD3Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (441 aa)
LRP11LDL receptor related protein 11. (438 aa)
ALOX5APArachidonate 5-lipoxygenase activating protein. (255 aa)
GLRX2Glutaredoxin 2. (160 aa)
LOC111090444Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (65 aa)
ADAAdenosine deaminase. (402 aa)
STK39Serine/threonine kinase 39. (555 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
FABP4Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (166 aa)
MT1EMetallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (64 aa)
PARK7Parkinsonism associated deglycase. (297 aa)
KDM6BLysine demethylase 6B. (1685 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (744 aa)
CARFCalcium responsive transcription factor. (734 aa)
ENSCAFP00000060413Uncharacterized protein. (88 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2407 aa)
ENSCAFP00000059886Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (142 aa)
STIM1Stromal interaction molecule 1. (825 aa)
SLC25A12Solute carrier family 25 member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (747 aa)
GUCY1B1Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. (672 aa)
NEK7NIMA related kinase 7; Belongs to the protein kinase superfamily. (338 aa)
RAD51DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Part of a PALB2-scaffolded HR [...] (317 aa)
MNAT1MNAT1 component of CDK activating kinase. (358 aa)
RNF112Ring finger protein 112. (895 aa)
PRDX1Thioredoxin domain-containing protein. (280 aa)
ENSCAFP00000056985Thioredoxin domain-containing protein. (100 aa)
SYT2Synaptotagmin 2. (465 aa)
ENSCAFP00000056705Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
ZFAND1Zinc finger AN1-type containing 1. (356 aa)
ENSCAFP000000564741-cysPrx_C domain-containing protein. (96 aa)
SLC41A1Solute carrier family 41 member 1. (562 aa)
SELENOMSep15_SelM domain-containing protein. (141 aa)
PTCH1Patched 1. (1449 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
SYT6Synaptotagmin 6. (528 aa)
ENSCAFP00000052866Uncharacterized protein. (60 aa)
ENSCAFP00000052207Thioredoxin domain-containing protein. (135 aa)
SYT5Synaptotagmin 5. (456 aa)
ENSCAFP00000051796Copine domain-containing protein. (109 aa)
ANKHANKH inorganic pyrophosphate transport regulator. (561 aa)
ENSCAFP00000051205Uncharacterized protein. (134 aa)
TFAP2ATranscription factor AP-2 alpha. (442 aa)
CPNE8Copine 8. (615 aa)
CPNE7Copine 7. (608 aa)
SYT9Olfactomedin like 1. (828 aa)
PRKAA1Non-specific serine/threonine protein kinase. (573 aa)
ATF1Activating transcription factor 1. (429 aa)
ENSCAFP00000050100Uncharacterized protein. (135 aa)
ECT2Epithelial cell transforming 2. (943 aa)
CPS1Carbamoyl-phosphate synthase 1. (1532 aa)
TREX1Three prime repair exonuclease 1. (373 aa)
HDAC6Histone deacetylase 6. (1186 aa)
TIMELESSTimeless circadian regulator. (1297 aa)
DAXXDeath domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 throu [...] (735 aa)
ANXA11Annexin. (713 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (448 aa)
OSER1Oxidative stress responsive serine rich 1. (360 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK3-2Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1206 aa)
RIPK3Protein kinase domain-containing protein. (423 aa)
ENSCAFP00000047314Uncharacterized protein. (153 aa)
SLC25A23Solute carrier family 25 member 23; Belongs to the mitochondrial carrier (TC 2.A.29) family. (735 aa)
ENSCAFP00000047095Uncharacterized protein. (71 aa)
MEF2AMyocyte enhancer factor 2A. (609 aa)
SLC30A10Solute carrier family 30 member 10. (341 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (504 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (363 aa)
LOC474798Thioredoxin domain-containing protein. (184 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (605 aa)
CPNE5Copine 5. (651 aa)
SRCTyrosine-protein kinase. (553 aa)
ENSCAFP00000044350Uncharacterized protein. (209 aa)
RTF2Replication termination factor 2. (349 aa)
FANCCFA complementation group C. (749 aa)
AQP1Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (373 aa)
HVCN1Hydrogen voltage gated channel 1. (271 aa)
IMPACTImpact RWD domain protein. (421 aa)
SOD2Superoxide dismutase [Mn], mitochondrial. (570 aa)
LOC489080Uncharacterized protein. (549 aa)
J9PB83_CANLFFABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (120 aa)
SPIDRScaffold protein involved in DNA repair. (941 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (925 aa)
CCSSuperoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (317 aa)
RUNX2RUNX family transcription factor 2. (476 aa)
SLC38A2Solute carrier family 38 member 2. (573 aa)
CYBRD1Cytochrome b reductase 1. (281 aa)
RASGRP2RAS guanyl releasing protein 2. (633 aa)
KCNJ10Potassium voltage-gated channel subfamily J member 10. (414 aa)
CUTACutA divalent cation tolerance homolog. (194 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1. (370 aa)
SYT17Synaptotagmin 17. (562 aa)
J9P7L3_CANLFThioredoxin domain-containing protein. (199 aa)
SLC30A1Solute carrier family 30 member 1. (492 aa)
ACO1Aconitase 1; Belongs to the aconitase/IPM isomerase family. (901 aa)
SELENOPSelP_N domain-containing protein. (208 aa)
LOC100856408Uncharacterized protein. (206 aa)
J9P3C7_CANLFFABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (109 aa)
J9P228_CANLFSuperoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (152 aa)
LOC100855763Nudix hydrolase domain-containing protein. (1496 aa)
PEF1Penta-EF-hand domain containing 1. (121 aa)
SLC30A2Solute carrier family 30 member 2. (511 aa)
NFATC4Nuclear factor of activated T cells 4. (946 aa)
ZNF580Zinc finger protein 580. (172 aa)
LOC100686507FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (172 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (273 aa)
BMP6Bone morphogenetic protein 6. (335 aa)
J9NWJ5_CANLFThioredoxin; Belongs to the thioredoxin family. (106 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (842 aa)
RASAL1RAS protein activator like 1. (805 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (318 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
KCNMB3Potassium calcium-activated channel subfamily M regulatory beta subunit 3. (283 aa)
FXNFrataxin. (211 aa)
F1PSH3_CANLFC2 domain-containing protein. (153 aa)
BADBCL2 associated agonist of cell death. (167 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (601 aa)
BNIP3BCL2 interacting protein 3. (354 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (263 aa)
PRDX2Peroxiredoxin 2. (198 aa)
DDI1DNA damage inducible 1 homolog 1. (395 aa)
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (539 aa)
BAP1Ubiquitin carboxyl-terminal hydrolase. (729 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (658 aa)
PLCG2Phosphoinositide phospholipase C. (1336 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
SETXSenataxin. (2700 aa)
DPEP1Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (446 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (547 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
F1PXS7_CANLFProtein kinase domain-containing protein. (232 aa)
PRKAA2Non-specific serine/threonine protein kinase. (532 aa)
STK26Serine/threonine kinase 26. (443 aa)
SLC1A3Amino acid transporter. (542 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (806 aa)
GLRA1Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (938 aa)
SYT4Synaptotagmin 4. (438 aa)
S100A16Protein S100; Belongs to the S-100 family. (103 aa)
ATRXATRX chromatin remodeler. (2489 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2380 aa)
MAPK3Mitogen-activated protein kinase. (283 aa)
SYT11Synaptotagmin 11. (431 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
SLC34A1Solute carrier family 34 member 1. (639 aa)
MIEN1Migration and invasion enhancer 1. (115 aa)
SYT7Synaptotagmin 7. (853 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (936 aa)
ALOX12Arachidonate 15-lipoxygenase. (664 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1125 aa)
KCNMB2Potassium calcium-activated channel subfamily M regulatory beta subunit 2. (235 aa)
KCNMA1Calcium-activated potassium channel subunit alpha-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in t [...] (1206 aa)
SLC13A5Solute carrier family 13 member 5. (571 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (312 aa)
ANKZF1Ankyrin repeat and zinc finger domain containing 1. (721 aa)
ABCB6ATP binding cassette subfamily B member 6. (972 aa)
PDCD10Programmed cell death 10. (212 aa)
TXNRD2Thioredoxin reductase 2. (536 aa)
TFR2Transferrin receptor 2. (806 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
ADORA2AAdenosine receptor A2a; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. (412 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
RELARELA proto-oncogene, NF-kB subunit. (542 aa)
SIRT1Sirtuin 1. (745 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (198 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
BLMBLM RecQ like helicase. (1420 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1179 aa)
PRDX3Thioredoxin domain-containing protein. (278 aa)
CAPN9Calpain 9; Belongs to the peptidase C2 family. (692 aa)
SLC18A2Solute carrier family 18 member A2. (669 aa)
GLRA2Glycine receptor alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (452 aa)
SYT12Synaptotagmin 12. (447 aa)
CASRCalcium-sensing receptor. (1075 aa)
CPNE6Copine 6. (557 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (204 aa)
PDCD6Programmed cell death 6. (187 aa)
LGMNLegumain. (470 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
H9GWA7_CANLFIon_trans domain-containing protein. (622 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (821 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CRYAAAlpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. (173 aa)
SYT10Synaptotagmin 10. (576 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (842 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
FIBINFin bud initiation factor homolog (zebrafish). (211 aa)
SYT8Synaptotagmin 8. (403 aa)
RYR2Ryanodine receptor 2. (4903 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1055 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (202 aa)
DMTNDematin actin binding protein. (399 aa)
PPP1R15BProtein phosphatase 1 regulatory subunit 15B. (709 aa)
PKD2L1Polycystin 2 like 1, transient receptor potential cation channel. (858 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (874 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
ITPKAKinase; Belongs to the inositol phosphokinase (IPK) family. (453 aa)
SYT13Synaptotagmin 13. (426 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (669 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
LOXL2Lysyl oxidase like 2. (774 aa)
MT4Metallothionein-4; Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia (By similarity). (62 aa)
LOC100686073Metallothionein-1; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family. (61 aa)
MT2AMetallothionein-2; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. (268 aa)
HOMER1Homer scaffold protein 1. (354 aa)
SLC12A3Solute carrier family 12 member 3. (1030 aa)
CPNE2Copine 2. (548 aa)
CPNE3Copine 3. (555 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. (148 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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