(23 nodes) Protein kinase A signaling network (Canis lupus familiaris)

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Predicted Interactions

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Your Input:
	EDNRA	Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (426 aa)
	MROH1	Maestro heat like repeat family member 1. (1486 aa)
	GCG	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] (180 aa)
	FBN1	Uncharacterized protein. (2871 aa)
	RAB13	Ras-related protein Rab-13; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regu [...] (203 aa)
	LOC609833	Uncharacterized protein. (426 aa)
	MYOM1	Myomesin 1. (1724 aa)
	MROH2B	Maestro heat like repeat family member 2B. (1586 aa)
	MROH7	Uncharacterized protein. (1324 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
	MRO	Maestro. (251 aa)
	LOC102152171	Uncharacterized protein. (898 aa)
	LOC102152141	Maestro heat-like repeat-containing protein family member 7. (898 aa)
	LOC475111	Uncharacterized protein. (1061 aa)
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (350 aa)
	LCP1	Lymphocyte cytosolic protein 1. (753 aa)
	MROH2A	Maestro heat like repeat family member 2A. (1669 aa)
	EDN1	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (202 aa)
	MROH8	Maestro heat like repeat family member 8. (1035 aa)
	LOC100686869	Uncharacterized protein. (195 aa)
	TCP11	T-complex 11. (502 aa)
	MROH5	Maestro heat like repeat family member 5 (gene/pseudogene). (1375 aa)
	EZR	FERM domain-containing protein. (586 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDN1	EDNRA	ENSCAFP00000014389	ENSCAFP00000011497	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).	0.999
EDN1	GCG	ENSCAFP00000014389	ENSCAFP00000015307	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...]	0.557
EDN1	PRKACA	ENSCAFP00000014389	ENSCAFP00000053880	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.499
EDN1	PRKACB	ENSCAFP00000014389	ENSCAFP00000030135	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.499
EDNRA	EDN1	ENSCAFP00000011497	ENSCAFP00000014389	Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.999
EZR	PRKACA	ENSCAFP00000000937	ENSCAFP00000053880	FERM domain-containing protein.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.976
EZR	PRKACB	ENSCAFP00000000937	ENSCAFP00000030135	FERM domain-containing protein.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.976
GCG	EDN1	ENSCAFP00000015307	ENSCAFP00000014389	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...]	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.557
GCG	PRKACA	ENSCAFP00000015307	ENSCAFP00000053880	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...]	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.528
GCG	PRKACB	ENSCAFP00000015307	ENSCAFP00000030135	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...]	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.529
LOC100686869	PRKACA	ENSCAFP00000066226	ENSCAFP00000053880	Uncharacterized protein.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.905
LOC100686869	PRKACB	ENSCAFP00000066226	ENSCAFP00000030135	Uncharacterized protein.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.905
LOC100686869	RAB13	ENSCAFP00000066226	ENSCAFP00000025621	Uncharacterized protein.	Ras-related protein Rab-13; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regu [...]	0.901
MROH2A	MROH2B	ENSCAFP00000017506	ENSCAFP00000027456	Maestro heat like repeat family member 2A.	Maestro heat like repeat family member 2B.	0.466
MROH2A	MROH8	ENSCAFP00000017506	ENSCAFP00000012816	Maestro heat like repeat family member 2A.	Maestro heat like repeat family member 8.	0.478
MROH2B	MROH2A	ENSCAFP00000027456	ENSCAFP00000017506	Maestro heat like repeat family member 2B.	Maestro heat like repeat family member 2A.	0.466
MROH2B	MROH7	ENSCAFP00000027456	ENSCAFP00000028049	Maestro heat like repeat family member 2B.	Uncharacterized protein.	0.405
MROH2B	MROH8	ENSCAFP00000027456	ENSCAFP00000012816	Maestro heat like repeat family member 2B.	Maestro heat like repeat family member 8.	0.454
MROH7	MROH2B	ENSCAFP00000028049	ENSCAFP00000027456	Uncharacterized protein.	Maestro heat like repeat family member 2B.	0.405
MROH8	MROH2A	ENSCAFP00000012816	ENSCAFP00000017506	Maestro heat like repeat family member 8.	Maestro heat like repeat family member 2A.	0.478