(18 nodes) Negative regulation of gliogenesis network (Canis lupus familiaris)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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co-expression

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Your Input:
	NF1	Neurofibromin 1. (2784 aa)
	GPR37L1	G protein-coupled receptor 37 like 1. (458 aa)
	DLX2	Distal-less homeobox 2. (334 aa)
	NF2	Neurofibromin 2. (597 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (385 aa)
	NOTCH1	Notch receptor 1. (2565 aa)
	HES5	Hes family bHLH transcription factor 5. (165 aa)
	TMEM98	Transmembrane protein 98. (226 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (612 aa)
	NKX6-2	NK6 homeobox 2. (309 aa)
	ATOH1	Atonal bHLH transcription factor 1. (356 aa)
	NKX6-1	NK6 homeobox 1. (366 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (445 aa)
	DLX1	Distal-less homeobox 1. (265 aa)
	RB1	RB transcriptional corepressor 1. (927 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (523 aa)
	LDLR	Low density lipoprotein receptor. (888 aa)
	F2	Coagulation factor II, thrombin; Belongs to the peptidase S1 family. (670 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATOH1	HES5	ENSCAFP00000014743	ENSCAFP00000028708	Atonal bHLH transcription factor 1.	Hes family bHLH transcription factor 5.	0.515
ATOH1	NOTCH1	ENSCAFP00000014743	ENSCAFP00000029073	Atonal bHLH transcription factor 1.	Notch receptor 1.	0.519
DLX1	DLX2	ENSCAFP00000064473	ENSCAFP00000031627	Distal-less homeobox 1.	Distal-less homeobox 2.	0.788
DLX1	HES5	ENSCAFP00000064473	ENSCAFP00000028708	Distal-less homeobox 1.	Hes family bHLH transcription factor 5.	0.494
DLX2	DLX1	ENSCAFP00000031627	ENSCAFP00000064473	Distal-less homeobox 2.	Distal-less homeobox 1.	0.788
DLX2	HES5	ENSCAFP00000031627	ENSCAFP00000028708	Distal-less homeobox 2.	Hes family bHLH transcription factor 5.	0.563
HES5	ATOH1	ENSCAFP00000028708	ENSCAFP00000014743	Hes family bHLH transcription factor 5.	Atonal bHLH transcription factor 1.	0.515
HES5	DLX1	ENSCAFP00000028708	ENSCAFP00000064473	Hes family bHLH transcription factor 5.	Distal-less homeobox 1.	0.494
HES5	DLX2	ENSCAFP00000028708	ENSCAFP00000031627	Hes family bHLH transcription factor 5.	Distal-less homeobox 2.	0.563
HES5	NOTCH1	ENSCAFP00000028708	ENSCAFP00000029073	Hes family bHLH transcription factor 5.	Notch receptor 1.	0.658
NF1	NF2	ENSCAFP00000035952	ENSCAFP00000031455	Neurofibromin 1.	Neurofibromin 2.	0.788
NF1	TP53	ENSCAFP00000035952	ENSCAFP00000064590	Neurofibromin 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.748
NF2	NF1	ENSCAFP00000031455	ENSCAFP00000035952	Neurofibromin 2.	Neurofibromin 1.	0.788
NF2	TP53	ENSCAFP00000031455	ENSCAFP00000064590	Neurofibromin 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.536
NOTCH1	ATOH1	ENSCAFP00000029073	ENSCAFP00000014743	Notch receptor 1.	Atonal bHLH transcription factor 1.	0.519
NOTCH1	HES5	ENSCAFP00000029073	ENSCAFP00000028708	Notch receptor 1.	Hes family bHLH transcription factor 5.	0.658
NOTCH1	TP53	ENSCAFP00000029073	ENSCAFP00000064590	Notch receptor 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.685
RB1	TP53	ENSCAFP00000057502	ENSCAFP00000064590	RB transcriptional corepressor 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.468
TP53	NF1	ENSCAFP00000064590	ENSCAFP00000035952	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	Neurofibromin 1.	0.748
TP53	NF2	ENSCAFP00000064590	ENSCAFP00000031455	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	Neurofibromin 2.	0.536