STRINGSTRING
ERBB3 ERBB3 PIK3CG PIK3CG GATA3 GATA3 LOC606856 LOC606856 MYO16 MYO16 PIK3CB PIK3CB PIK3R1 PIK3R1 PREX2 PREX2 PIK3C2B PIK3C2B EDN1 EDN1 CD160 CD160 PIK3R2 PIK3R2 C1QBP C1QBP ZFP36L1 ZFP36L1 PEAR1 PEAR1 SERPINA12 SERPINA12 RPS6KB1 RPS6KB1 PIK3CD PIK3CD NF1 NF1 KBTBD2 KBTBD2 PIK3C2A PIK3C2A HTR2B HTR2B PRR5 PRR5 NYAP1 NYAP1 PTEN PTEN PIK3CA PIK3CA NYAP2 NYAP2 ENSCAFP00000049628 ENSCAFP00000049628 HTR2A HTR2A PPARD PPARD CD28 CD28 PIK3C2G PIK3C2G SIRT2 SIRT2 PRR5L PRR5L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERBB3Erb-b2 receptor tyrosine kinase 3. (1338 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1104 aa)
GATA3GATA binding protein 3. (444 aa)
LOC606856Uncharacterized protein. (740 aa)
MYO16Myosin XVI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (939 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PREX2Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1605 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (202 aa)
CD160CD160 molecule. (277 aa)
PIK3R2Uncharacterized protein. (726 aa)
C1QBPComplement C1q binding protein. (272 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
PEAR1Platelet endothelial aggregation receptor 1. (1059 aa)
SERPINA12Serpin family A member 12; Belongs to the serpin family. (414 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa)
NF1Neurofibromin 1. (2784 aa)
KBTBD2Kelch repeat and BTB domain containing 2. (565 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1693 aa)
HTR2B5-hydroxytryptamine receptor 2B. (477 aa)
PRR5Proline rich 5. (389 aa)
NYAP1Neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1. (1051 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] (403 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NYAP2Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2. (767 aa)
ENSCAFP00000049628AGC-kinase C-terminal domain-containing protein. (66 aa)
HTR2A5-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. S [...] (512 aa)
PPARDPeroxisome proliferator-activated receptor delta; Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma- linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (By similarity). (473 aa)
CD28CD28 molecule. (246 aa)
PIK3C2GPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1477 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (334 aa)
PRR5LProline rich 5 like. (379 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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