STRINGSTRING
NETO1 NETO1 DCC DCC GRM1 GRM1 MAPK8IP2 MAPK8IP2 SYNGAP1 SYNGAP1 ADCY8 ADCY8 PICK1 PICK1 LRRC4 LRRC4 ABHD17B ABHD17B SEMA4C SEMA4C LRRC4B LRRC4B ADD2 ADD2 GRIK2 GRIK2 PRR12 PRR12 SLC8A2 SLC8A2 GRIN2C GRIN2C PAK3 PAK3 ATP2B2 ATP2B2 CAMK1 CAMK1 RPS3 RPS3 LRFN1 LRFN1 PLCB4 PLCB4 ITPR1 ITPR1 PCLO PCLO LZTS3 LZTS3 BFSP2 BFSP2 LRRC4C LRRC4C RGS7BP RGS7BP MAP1B MAP1B P2RX4 P2RX4 HOMER1 HOMER1 PKP4 PKP4 DMTN DMTN DTNBP1 DTNBP1 CAP2 CAP2 PSD PSD LIN7C LIN7C SHANK2 SHANK2 SORCS3 SORCS3 ADD3 ADD3 GAP43 GAP43 RGS9 RGS9 NRGN NRGN DISC1 DISC1 GPER1 GPER1 LRFN4 LRFN4 KPNA1 KPNA1 EIF3A EIF3A ADCY1 ADCY1 ALS2 ALS2 PTPRO PTPRO FBXO45 FBXO45 HOMER2 HOMER2 CADM1 CADM1 IL1RAPL1 IL1RAPL1 DGCR8 DGCR8 MPP2 MPP2 SLITRK3 SLITRK3 HOMER3 HOMER3 GNG3 GNG3 SH2D5 SH2D5 RTN3 RTN3 USP8 USP8 USP50 USP50 GRID1 GRID1 AKAP5 AKAP5 DAGLA DAGLA SYNJ2BP SYNJ2BP SYT11 SYT11 SHISA6 SHISA6 DNM2 DNM2 EEF2K EEF2K GRIA1 GRIA1 ARHGAP44 ARHGAP44 SYNPO SYNPO AK4 AK4 GRIN2A GRIN2A FMR1 FMR1 DVL1 DVL1 ABHD17A ABHD17A PALM PALM TSC1 TSC1 NCS1 NCS1 BMPR2 BMPR2 F1PLY9_CANLF F1PLY9_CANLF GRID2 GRID2 LOC106557533 LOC106557533 GRM5 GRM5 CACNG7 CACNG7 BAALC BAALC DROSHA DROSHA CTNND2 CTNND2 SHISA9 SHISA9 SHISA7 SHISA7 GRM3 GRM3 LRRC7 LRRC7 SAMD14 SAMD14 FABP5 FABP5 GRIN1 GRIN1 NETO2 NETO2 TSC2 TSC2 SLITRK1 SLITRK1 RTN4 RTN4 CLSTN2 CLSTN2 J9P1F7_CANLF J9P1F7_CANLF INSYN2A INSYN2A GRIN2B GRIN2B CACNG5 CACNG5 LOC477516 LOC477516 CACNG8 CACNG8 SIGMAR1 SIGMAR1 INSYN1 INSYN1 NGFR NGFR NEURL1 NEURL1 CACNG3 CACNG3 SORCS2 SORCS2 ENSCAFP00000044350 ENSCAFP00000044350 SYNDIG1 SYNDIG1 SRCIN1 SRCIN1 ENSCAFP00000046421 ENSCAFP00000046421 BSN BSN ENSCAFP00000047314 ENSCAFP00000047314 ERBB4 ERBB4 ADAM10 ADAM10 NPTN NPTN RGS14 RGS14 LIN7B LIN7B ARHGEF9 ARHGEF9 PDE4B PDE4B SCRIB SCRIB LRFN2 LRFN2 LRFN5 LRFN5 DLG5 DLG5 FXR2 FXR2 ENSCAFP00000053140 ENSCAFP00000053140 PPP1R9B PPP1R9B PDPK1 PDPK1 ENSCAFP00000053718 ENSCAFP00000053718 EPS8 EPS8 GSG1L GSG1L CRIPT CRIPT PLEKHA5 PLEKHA5 CDK5 CDK5 DBNL DBNL ADAM22 ADAM22 RNF112 RNF112 CLSTN3 CLSTN3 DBN1 DBN1 PRRT1 PRRT1 ENSCAFP00000060413 ENSCAFP00000060413 DLG4 DLG4 CACNG2 CACNG2 GRIN2D GRIN2D LIN7A LIN7A NTRK2 NTRK2 FXR1 FXR1 CLSTN1 CLSTN1 BCR BCR CPEB4 CPEB4 PAK2 PAK2 ENSCAFP00000065556 ENSCAFP00000065556 ADD1 ADD1 DCLK1 DCLK1 PPP1R9A PPP1R9A ADGRA1 ADGRA1 CACNG4 CACNG4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NETO1Neuropilin and tolloid like 1. (533 aa)
DCCDCC netrin 1 receptor. (1416 aa)
GRM1Glutamate metabotropic receptor 1. (1195 aa)
MAPK8IP2Mitogen-activated protein kinase 8 interacting protein 2. (824 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (612 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
PICK1Protein interacting with PRKCA 1. (417 aa)
LRRC4Leucine rich repeat containing 4. (650 aa)
ABHD17BAbhydrolase domain containing 17B. (293 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
LRRC4BLeucine rich repeat containing 4B. (717 aa)
ADD2Adducin 2. (722 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
PRR12Proline rich 12. (2032 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1077 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (1212 aa)
PAK3P21 (RAC1) activated kinase 3. (583 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (492 aa)
RPS340S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8- dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] (243 aa)
LRFN1Leucine rich repeat and fibronectin type III domain containing 1. (770 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2628 aa)
PCLOPiccolo presynaptic cytomatrix protein. (4823 aa)
LZTS3Leucine zipper tumor suppressor family member 3. (673 aa)
BFSP2Transmembrane protein 108. (572 aa)
LRRC4CLeucine rich repeat containing 4C. (639 aa)
RGS7BPRegulator of G protein signaling 7 binding protein. (257 aa)
MAP1BMicrotubule associated protein 1B. (2576 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
HOMER1Homer scaffold protein 1. (354 aa)
PKP4Plakophilin 4. (1222 aa)
DMTNDematin actin binding protein. (399 aa)
DTNBP1Dystrobrevin binding protein 1. (341 aa)
CAP2Adenylyl cyclase-associated protein; Belongs to the CAP family. (477 aa)
PSDPleckstrin and Sec7 domain containing. (1028 aa)
LIN7CProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (197 aa)
SHANK2SH3 and multiple ankyrin repeat domains 2. (1476 aa)
SORCS3Sortilin related VPS10 domain containing receptor 3. (1206 aa)
ADD3Adducin 3. (706 aa)
GAP43Growth associated protein 43. (291 aa)
RGS9Regulator of G protein signaling 9. (847 aa)
NRGNNeurogranin. (78 aa)
DISC1DISC1 scaffold protein. (848 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (384 aa)
LRFN4Leucine rich repeat and fibronectin type III domain containing 4. (636 aa)
KPNA1Importin subunit alpha; Functions in nuclear protein import. (538 aa)
EIF3AEukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] (1350 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1179 aa)
ALS2Alsin Rho guanine nucleotide exchange factor ALS2. (1656 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1450 aa)
FBXO45F-box protein 45. (106 aa)
HOMER2Homer scaffold protein 2. (370 aa)
CADM1Cell adhesion molecule 1. (474 aa)
IL1RAPL1Interleukin 1 receptor accessory protein like 1. (696 aa)
DGCR8DGCR8 microprocessor complex subunit. (773 aa)
MPP2Membrane palmitoylated protein 2; Belongs to the MAGUK family. (593 aa)
SLITRK3SLIT and NTRK like family member 3. (979 aa)
HOMER3Homer scaffold protein 3. (360 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
SH2D5SH2 domain containing 5. (532 aa)
RTN3Reticulon. (1034 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1116 aa)
USP50Ubiquitin specific peptidase 50; Belongs to the peptidase C19 family. (373 aa)
GRID1Glutamate ionotropic receptor delta type subunit 1. (1054 aa)
AKAP5A-kinase anchoring protein 5. (428 aa)
DAGLADiacylglycerol lipase alpha. (901 aa)
SYNJ2BPPDZ domain-containing protein. (145 aa)
SYT11Synaptotagmin 11. (431 aa)
SHISA6Shisa family member 6. (266 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (880 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (938 aa)
ARHGAP44Rho GTPase activating protein 44. (813 aa)
SYNPOSynaptopodin. (1017 aa)
AK4DnaJ heat shock protein family (Hsp40) member C6. (1016 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
FMR1Fragile X mental retardation 1. (615 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
ABHD17AAbhydrolase domain containing 17A. (310 aa)
PALMParalemmin. (517 aa)
TSC1TSC complex subunit 1. (1169 aa)
NCS1Neuronal calcium sensor 1. (180 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
F1PLY9_CANLFUncharacterized protein. (106 aa)
GRID2Glutamate ionotropic receptor delta type subunit 2. (1007 aa)
LOC106557533Uncharacterized protein. (114 aa)
GRM5Glutamate metabotropic receptor 5. (1238 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
BAALCBAALC binder of MAP3K1 and KLF4. (145 aa)
DROSHADrosha ribonuclease III. (1398 aa)
CTNND2Catenin delta 2. (1246 aa)
SHISA9Shisa family member 9. (424 aa)
SHISA7Shisa family member 7. (535 aa)
GRM3Glutamate metabotropic receptor 3. (875 aa)
LRRC7Leucine rich repeat containing 7. (1574 aa)
SAMD14Sterile alpha motif domain containing 14. (417 aa)
FABP5Uncharacterized protein. (165 aa)
GRIN1Glutamate receptor ionotropic, NMDA 1; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily. (914 aa)
NETO2Neuropilin and tolloid like 2. (513 aa)
TSC2TSC complex subunit 2. (1783 aa)
SLITRK1SLIT and NTRK like family member 1. (696 aa)
RTN4Reticulon. (993 aa)
CLSTN2Calsyntenin 2. (957 aa)
J9P1F7_CANLFUncharacterized protein. (94 aa)
INSYN2AInhibitory synaptic factor 2A. (475 aa)
GRIN2BGlutamate receptor ionotropic, NMDA 2B; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition (By similarity). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator fo [...] (1485 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (326 aa)
LOC477516Uncharacterized protein. (315 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (406 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1. (370 aa)
INSYN1Inhibitory synaptic factor 1. (287 aa)
NGFRNerve growth factor receptor. (429 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (580 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
SORCS2Sortilin related VPS10 domain containing receptor 2. (1131 aa)
ENSCAFP00000044350Uncharacterized protein. (209 aa)
SYNDIG1Synapse differentiation inducing 1. (350 aa)
SRCIN1SRC kinase signaling inhibitor 1. (1587 aa)
ENSCAFP00000046421Uncharacterized protein. (175 aa)
BSNBassoon presynaptic cytomatrix protein. (3905 aa)
ENSCAFP00000047314Uncharacterized protein. (153 aa)
ERBB4Receptor protein-tyrosine kinase. (1324 aa)
ADAM10ADAM metallopeptidase domain 10. (750 aa)
NPTNNeuroplastin. (367 aa)
RGS14Regulator of G protein signaling 14. (564 aa)
LIN7BLin-7 homolog B, crumbs cell polarity complex component. (499 aa)
ARHGEF9Cdc42 guanine nucleotide exchange factor 9. (534 aa)
PDE4BPhosphodiesterase. (737 aa)
SCRIBScribble planar cell polarity protein. (1568 aa)
LRFN2Leucine rich repeat and fibronectin type III domain containing 2. (832 aa)
LRFN5Leucine rich repeat and fibronectin type III domain containing 5. (722 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1940 aa)
FXR2FMR1 autosomal homolog 2. (690 aa)
ENSCAFP00000053140Uncharacterized protein. (59 aa)
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (882 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (551 aa)
ENSCAFP00000053718Uncharacterized protein. (290 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (834 aa)
GSG1LGSG1 like. (463 aa)
CRIPTCXXC repeat containing interactor of PDZ3 domain. (342 aa)
PLEKHA5Pleckstrin homology domain containing A5. (1284 aa)
CDK5Cyclin dependent kinase 5. (390 aa)
DBNLDrebrin like. (472 aa)
ADAM22ADAM metallopeptidase domain 22. (970 aa)
RNF112Ring finger protein 112. (895 aa)
CLSTN3Calsyntenin 3. (990 aa)
DBN1Drebrin 1. (847 aa)
PRRT1Proline rich transmembrane protein 1. (374 aa)
ENSCAFP00000060413Uncharacterized protein. (88 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (744 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (343 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1172 aa)
LIN7AProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (228 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
FXR1FMR1 autosomal homolog 1. (648 aa)
CLSTN1Calsyntenin 1. (1013 aa)
BCRBCR activator of RhoGEF and GTPase. (1262 aa)
CPEB4Cytoplasmic polyadenylation element binding protein 4. (742 aa)
PAK2Non-specific serine/threonine protein kinase. (718 aa)
ENSCAFP00000065556Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (235 aa)
ADD1Adducin 1. (825 aa)
DCLK1Doublecortin like kinase 1. (760 aa)
PPP1R9AProtein phosphatase 1 regulatory subunit 9A. (1369 aa)
ADGRA1Adhesion G protein-coupled receptor A1. (584 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (314 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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