(77 nodes) Immunoglobulin mediated immune response network (Canis lupus familiaris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	JDP2	Jun dimerization protein 2. (358 aa)
	F1PP29_CANLF	Uncharacterized protein. (499 aa)
	C6	Complement C6. (956 aa)
	DEF6	DEF6 guanine nucleotide exchange factor. (631 aa)
	UNG	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (298 aa)
	ENSCAFP00000062222	Uncharacterized protein. (167 aa)
	ENSCAFP00000062039	Uncharacterized protein. (273 aa)
	C7	Complement C7. (892 aa)
	C3	Complement C3. (1566 aa)
	MORN5	MORN repeat containing 5. (278 aa)
	C9	Complement C9. (568 aa)
	C8B	Complement C8 beta chain. (590 aa)
	CD40LG	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (260 aa)
	CARD9	Caspase recruitment domain family member 9. (536 aa)
	LOC611642	Fibronectin type-III domain-containing protein. (505 aa)
	BCL10	BCL10 immune signaling adaptor. (233 aa)
	ATAD5	ATPase family AAA domain containing 5. (1825 aa)
	IL21R	Interleukin 21 receptor. (543 aa)
	NBN	Nibrin. (886 aa)
	C4BPB	Complement component 4 binding protein beta. (255 aa)
	C1QB	Complement C1q B chain. (250 aa)
	C1QA	Complement C1q A chain. (264 aa)
	C2	Complement C2; Belongs to the peptidase S1 family. (780 aa)
	HV02_CANLF	Ig heavy chain V region MOO. (150 aa)
	INPP5D	Inositol polyphosphate-5-phosphatase D. (1501 aa)
	ENSCAFP00000055668	Ig-like domain-containing protein. (142 aa)
	LOC484960	Anaphylatoxin-like domain-containing protein. (1593 aa)
	ENSCAFP00000054037	Ig-like domain-containing protein. (150 aa)
	RNF168	Ring finger protein 168. (585 aa)
	ENSCAFP00000053494	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (258 aa)
	ENSCAFP00000053409	SEFIR domain-containing protein. (199 aa)
	RNF8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (736 aa)
	ENSCAFP00000052690	Uncharacterized protein. (70 aa)
	HV01_CANLF	Ig heavy chain V region GOM. (474 aa)
	ENSCAFP00000050605	Uncharacterized protein. (360 aa)
	TREX1	Three prime repair exonuclease 1. (373 aa)
	ENSCAFP00000049448	Ig-like domain-containing protein. (105 aa)
	C8A	Complement C8 alpha chain. (608 aa)
	EXOSC6	Exosome component 6. (395 aa)
	ENSCAFP00000048133	Ig-like domain-containing protein. (138 aa)
	STAT6	Signal transducer and activator of transcription. (927 aa)
	CD74	CD74 molecule. (272 aa)
	CCR6	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (470 aa)
	ENSCAFP00000044582	Ig-like domain-containing protein. (144 aa)
	C1S	Complement C1s; Belongs to the peptidase S1 family. (696 aa)
	IL4R	Interleukin 4 receptor. (835 aa)
	ENSCAFP00000044033	Ig-like domain-containing protein. (150 aa)
	BTK	Tyrosine-protein kinase. (687 aa)
	SWAP70	Switching B cell complex subunit SWAP70. (590 aa)
	LOC481722	Uncharacterized protein. (1738 aa)
	C1RL	Complement C1r subcomponent like; Belongs to the peptidase S1 family. (555 aa)
	MSH6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1275 aa)
	CSF2RB	Colony stimulating factor 2 receptor beta common subunit. (902 aa)
	EXOSC3	Exosome component 3. (275 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
	PEX13	KIAA1841. (747 aa)
	C5	Complement C5. (1611 aa)
	TRAF3IP2	TRAF3 interacting protein 2. (560 aa)
	ERCC1	ERCC excision repair 1, endonuclease non-catalytic subunit. (314 aa)
	BCL3	BCL3 transcription coactivator. (566 aa)
	MYD88	MYD88 innate immune signal transduction adaptor. (398 aa)
	LIG4	DNA ligase. (911 aa)
	F6Y518_CANLF	IRF-3 domain-containing protein. (90 aa)
	CD81	Tetraspanin. (233 aa)
	TCIRG1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
	FCGR1A	Uncharacterized protein. (428 aa)
	FCER1G	Fc fragment of IgE receptor Ig. (86 aa)
	ZP3	Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. (441 aa)
	BCL6	B-cell lymphoma 6 protein. (706 aa)
	C1R	Complement C1r; Belongs to the peptidase S1 family. (719 aa)
	C1QC	Complement C1q C chain. (235 aa)
	C1QBP	Complement C1q binding protein. (272 aa)
	EXO1	Exonuclease 1. (836 aa)
	FOXP3	Forkhead box P3. (452 aa)
	MASP2	Mannan binding lectin serine peptidase 2; Belongs to the peptidase S1 family. (686 aa)
	CD19	CD19 molecule. (611 aa)
	ZP2	Processed zona pellucida sperm-binding protein 2; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. (715 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	EXO1	ENSCAFP00000036629	ENSCAFP00000023179	ATPase family AAA domain containing 5.	Exonuclease 1.	0.864
ATAD5	MSH2	ENSCAFP00000036629	ENSCAFP00000003876	ATPase family AAA domain containing 5.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.402
ATAD5	MSH6	ENSCAFP00000036629	ENSCAFP00000040899	ATPase family AAA domain containing 5.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.456
BCL10	CARD9	ENSCAFP00000030083	ENSCAFP00000029129	BCL10 immune signaling adaptor.	Caspase recruitment domain family member 9.	0.999
BCL10	ENSCAFP00000053409	ENSCAFP00000030083	ENSCAFP00000053409	BCL10 immune signaling adaptor.	SEFIR domain-containing protein.	0.449
BCL10	FCER1G	ENSCAFP00000030083	ENSCAFP00000018972	BCL10 immune signaling adaptor.	Fc fragment of IgE receptor Ig.	0.482
BCL10	TRAF3IP2	ENSCAFP00000030083	ENSCAFP00000005890	BCL10 immune signaling adaptor.	TRAF3 interacting protein 2.	0.449
BCL6	CCR6	ENSCAFP00000020491	ENSCAFP00000044791	B-cell lymphoma 6 protein.	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	0.762
BCL6	CD19	ENSCAFP00000020491	ENSCAFP00000025493	B-cell lymphoma 6 protein.	CD19 molecule.	0.670
BCL6	CD40LG	ENSCAFP00000020491	ENSCAFP00000027967	B-cell lymphoma 6 protein.	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	0.784
BCL6	FOXP3	ENSCAFP00000020491	ENSCAFP00000023435	B-cell lymphoma 6 protein.	Forkhead box P3.	0.828
BCL6	IL21R	ENSCAFP00000020491	ENSCAFP00000037398	B-cell lymphoma 6 protein.	Interleukin 21 receptor.	0.867
BCL6	JDP2	ENSCAFP00000020491	ENSCAFP00000055478	B-cell lymphoma 6 protein.	Jun dimerization protein 2.	0.529
BCL6	STAT6	ENSCAFP00000020491	ENSCAFP00000046565	B-cell lymphoma 6 protein.	Signal transducer and activator of transcription.	0.406
BTK	CD19	ENSCAFP00000043729	ENSCAFP00000025493	Tyrosine-protein kinase.	CD19 molecule.	0.711
BTK	CD40LG	ENSCAFP00000043729	ENSCAFP00000027967	Tyrosine-protein kinase.	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	0.509
BTK	CSF2RB	ENSCAFP00000043729	ENSCAFP00000002191	Tyrosine-protein kinase.	Colony stimulating factor 2 receptor beta common subunit.	0.479
BTK	ENSCAFP00000044033	ENSCAFP00000043729	ENSCAFP00000044033	Tyrosine-protein kinase.	Ig-like domain-containing protein.	0.555
BTK	ENSCAFP00000044582	ENSCAFP00000043729	ENSCAFP00000044582	Tyrosine-protein kinase.	Ig-like domain-containing protein.	0.547
BTK	ENSCAFP00000048133	ENSCAFP00000043729	ENSCAFP00000048133	Tyrosine-protein kinase.	Ig-like domain-containing protein.	0.555