(78 nodes) Antioxidant activity network (Canis lupus familiaris)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	J9P228_CANLF	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (152 aa)
	GPX1	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (204 aa)
	GSTO1	Glutathione S-transferase omega 1; Belongs to the GST superfamily. (361 aa)
	TP53INP1	Tumor protein p53 inducible nuclear protein 1. (239 aa)
	SOD1	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. (148 aa)
	GLRX	Glutaredoxin. (106 aa)
	CAT	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells. (528 aa)
	PXDNL	Peroxidasin like. (1468 aa)
	GSR	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (521 aa)
	YIPF5	Protein YIPF. (257 aa)
	MFSD11	Major facilitator superfamily domain containing 11. (449 aa)
	APOE	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (336 aa)
	SELENOW	Selenoprotein W. (87 aa)
	TXNRD3	Thioredoxin reductase 3. (464 aa)
	F1PFM4_CANLF	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (270 aa)
	PXDN	Peroxidasin. (1359 aa)
	TPO	Thyroid peroxidase; Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). Belongs to the peroxidase family. XPO subfamily. (944 aa)
	PRXL2C	Peroxiredoxin like 2C. (230 aa)
	APOM	Apolipoprotein M. (188 aa)
	LTC4S	Leukotriene C4 synthase. (188 aa)
	TXNL1	Thioredoxin like 1. (289 aa)
	RTTN	Rotatin. (2225 aa)
	PARK7	Parkinsonism associated deglycase. (297 aa)
	GSTO2	Glutathione S-transferase omega 2; Belongs to the GST superfamily. (337 aa)
	PRDX1	Thioredoxin domain-containing protein. (280 aa)
	ENSCAFP00000056474	1-cysPrx_C domain-containing protein. (96 aa)
	ENSCAFP00000055837	Uncharacterized protein. (69 aa)
	EPX	Eosinophil peroxidase. (645 aa)
	PRDX6	Peroxiredoxin 6. (236 aa)
	ENSCAFP00000052214	DSBA domain-containing protein. (175 aa)
	ENSCAFP00000052207	Thioredoxin domain-containing protein. (135 aa)
	PRXL2B	Peroxiredoxin like 2B. (304 aa)
	ENSCAFP00000047060	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (275 aa)
	S100A9	EF-hand domain-containing protein; Belongs to the S-100 family. (186 aa)
	PTGS1	Prostaglandin G/H synthase 1; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (By similarity). (724 aa)
	SOD2	Superoxide dismutase [Mn], mitochondrial. (570 aa)
	J9PB41_CANLF	Thioredoxin domain-containing protein. (245 aa)
	SESN2	Sestrin 2. (485 aa)
	CSN1S1	Casein alpha s1. (177 aa)
	J9P7L3_CANLF	Thioredoxin domain-containing protein. (199 aa)
	CLIC2	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (239 aa)
	PTGES	Prostaglandin E synthase; Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). (153 aa)
	SRXN1	Sulfiredoxin. (95 aa)
	GPX3	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (225 aa)
	SELENOT	Selenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (194 aa)
	GPX8	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
	J9NXF3_CANLF	Thioredoxin domain-containing protein. (269 aa)
	SELENOS	Selenoprotein S. (189 aa)
	ENSCAFP00000036430	annotation not available (152 aa)
	GSTK1	Glutathione S-transferase kappa. (226 aa)
	F1PVK0_CANLF	DSBA domain-containing protein. (165 aa)
	GPX5	Epididymal secretory glutathione peroxidase; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. (221 aa)
	CLIC6	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (247 aa)
	PRDX2	Peroxiredoxin 2. (198 aa)
	LOC479668	Haptoglobin alpha chain; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pat [...] (347 aa)
	NXN	Nucleoredoxin. (540 aa)
	BTBD6	BTB domain containing 6. (410 aa)
	MPO	Myeloperoxidase. (890 aa)
	LPO	Lactoperoxidase. (714 aa)
	UBIAD1	UbiA prenyltransferase domain containing 1. (337 aa)
	GPX2	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (189 aa)
	PRXL2A	Peroxiredoxin like 2A. (489 aa)
	TMEM221	Uncharacterized protein. (291 aa)
	PRDX5	Redoxin domain-containing protein. (174 aa)
	TXNRD2	Thioredoxin reductase 2. (536 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (604 aa)
	DUOX1	Dual oxidase 1; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. (1551 aa)
	DUOX2	Dual oxidase 2. (1519 aa)
	PRDX4	Peroxiredoxin 4. (276 aa)
	MGST3	Microsomal glutathione S-transferase 3. (152 aa)
	MGST1	Microsomal glutathione S-transferase 1. (166 aa)
	PRDX3	Thioredoxin domain-containing protein. (278 aa)
	GPX6	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (220 aa)
	ALOX5AP	Arachidonate 5-lipoxygenase activating protein. (255 aa)
	UPK3BL2	Uncharacterized protein. (317 aa)
	SOD3	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (441 aa)
	TXNRD1	Thioredoxin reductase 1; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (744 aa)
	TXNDC17	Thioredoxin domain containing 17. (131 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALOX5AP	LTC4S	ENSCAFP00000063629	ENSCAFP00000000503	Arachidonate 5-lipoxygenase activating protein.	Leukotriene C4 synthase.	0.754
APOE	APOM	ENSCAFP00000006888	ENSCAFP00000000845	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Apolipoprotein M.	0.487
APOE	GPX1	ENSCAFP00000006888	ENSCAFP00000016889	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.483
APOE	LOC479668	ENSCAFP00000006888	ENSCAFP00000029992	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Haptoglobin alpha chain; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pat [...]	0.481
APOE	PTGS2	ENSCAFP00000006888	ENSCAFP00000020288	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Prostaglandin-endoperoxide synthase 2.	0.431
APOE	PXDN	ENSCAFP00000006888	ENSCAFP00000004792	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Peroxidasin.	0.581
APOE	PXDNL	ENSCAFP00000006888	ENSCAFP00000010033	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Peroxidasin like.	0.466
APOM	APOE	ENSCAFP00000000845	ENSCAFP00000006888	Apolipoprotein M.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.487
CAT	ENSCAFP00000047060	ENSCAFP00000010324	ENSCAFP00000047060	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily.	0.400
CAT	ENSCAFP00000052207	ENSCAFP00000010324	ENSCAFP00000052207	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Thioredoxin domain-containing protein.	0.570
CAT	ENSCAFP00000055837	ENSCAFP00000010324	ENSCAFP00000055837	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Uncharacterized protein.	0.644
CAT	ENSCAFP00000056474	ENSCAFP00000010324	ENSCAFP00000056474	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	1-cysPrx_C domain-containing protein.	0.570
CAT	F1PFM4_CANLF	ENSCAFP00000010324	ENSCAFP00000005561	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.555
CAT	GLRX	ENSCAFP00000010324	ENSCAFP00000011683	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Glutaredoxin.	0.409
CAT	GPX1	ENSCAFP00000010324	ENSCAFP00000016889	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.443
CAT	GPX2	ENSCAFP00000010324	ENSCAFP00000023828	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.438
CAT	GPX3	ENSCAFP00000010324	ENSCAFP00000038899	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.438
CAT	GPX5	ENSCAFP00000010324	ENSCAFP00000034092	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Epididymal secretory glutathione peroxidase; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.	0.443
CAT	GPX6	ENSCAFP00000010324	ENSCAFP00000017566	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.438
CAT	GPX8	ENSCAFP00000010324	ENSCAFP00000037980	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.555