(51 nodes) Inclusion body network (Canis lupus familiaris)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HDAC6	Histone deacetylase 6. (1186 aa)
	ATF4	Activating transcription factor 4. (350 aa)
	FBXO7	F-box protein 7. (523 aa)
	POLD1	DNA polymerase. (1107 aa)
	GYS1	Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (735 aa)
	EPS15	Epidermal growth factor receptor pathway substrate 15. (891 aa)
	MT3	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
	RNF32	Ring finger protein 32. (369 aa)
	SFMBT2	Scm like with four mbt domains 2. (894 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
	XRN2	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (950 aa)
	RAD18	RAD18 E3 ubiquitin protein ligase. (503 aa)
	EDEM1	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (376 aa)
	CARD14	Caspase recruitment domain family member 14. (1029 aa)
	ZDHHC17	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (614 aa)
	NUP98	Nucleoporin 98. (1817 aa)
	PRNP	Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...] (255 aa)
	TRIM66	Tripartite motif containing 66. (1374 aa)
	SLF1	SMC5-SMC6 complex localization factor 1. (956 aa)
	LRRK2	Leucine rich repeat kinase 2. (2527 aa)
	NUP153	Nucleoporin 153. (1478 aa)
	TDP2	Tyrosyl-DNA phosphodiesterase 2. (330 aa)
	FGR	Tyrosine-protein kinase. (526 aa)
	STRADB	STE20 related adaptor beta. (414 aa)
	HOXD3	Homeobox D3. (431 aa)
	TPR	Translocated promoter region, nuclear basket protein. (2361 aa)
	HTT	Huntingtin. (3130 aa)
	DVL2	Dishevelled segment polarity protein 2. (736 aa)
	HSPB7	Heat shock protein family B (small) member 7; Belongs to the small heat shock protein (HSP20) family. (275 aa)
	KLF8	Kruppel like factor 8. (352 aa)
	PSEN1	Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (466 aa)
	TRIM37	Tripartite motif containing 37. (973 aa)
	KEAP1	Kelch like ECH associated protein 1. (624 aa)
	ZP2	Processed zona pellucida sperm-binding protein 2; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. (715 aa)
	KLHL14	Kelch like family member 14. (629 aa)
	BAG5	BCL2 associated athanogene 5. (456 aa)
	EEF2	Eukaryotic translation elongation factor 2. (858 aa)
	ZBTB14	Zinc finger and BTB domain containing 14. (449 aa)
	CABIN1	Calcineurin binding protein 1. (2186 aa)
	NBN	Nibrin. (886 aa)
	ATXN1	Ataxin 1. (841 aa)
	PRDM16	PR/SET domain 16. (1263 aa)
	HERPUD1	Homocysteine inducible ER protein with ubiquitin like domain 1. (393 aa)
	SQSTM1	Sequestosome 1. (551 aa)
	RANBP2	RAN binding protein 2. (3187 aa)
	URB2	URB2 ribosome biogenesis homolog. (1521 aa)
	WDFY3	WD repeat and FYVE domain containing 3. (3630 aa)
	SNCB	Beta-synuclein; Belongs to the synuclein family. (245 aa)
	ENSCAFP00000052780	Uncharacterized protein. (377 aa)
	ENSCAFP00000051796	Copine domain-containing protein. (109 aa)
	PRKN	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (464 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF4	EDEM1	ENSCAFP00000001900	ENSCAFP00000008377	Activating transcription factor 4.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.513
ATF4	HERPUD1	ENSCAFP00000001900	ENSCAFP00000039708	Activating transcription factor 4.	Homocysteine inducible ER protein with ubiquitin like domain 1.	0.523
ATXN1	HTT	ENSCAFP00000037698	ENSCAFP00000021648	Ataxin 1.	Huntingtin.	0.667
BAG5	LRRK2	ENSCAFP00000027001	ENSCAFP00000014627	BCL2 associated athanogene 5.	Leucine rich repeat kinase 2.	0.401
BAG5	PRKN	ENSCAFP00000027001	ENSCAFP00000050441	BCL2 associated athanogene 5.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.513
BAG5	SQSTM1	ENSCAFP00000027001	ENSCAFP00000065910	BCL2 associated athanogene 5.	Sequestosome 1.	0.405
CARD14	PRKCQ	ENSCAFP00000008411	ENSCAFP00000007725	Caspase recruitment domain family member 14.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.920
DVL2	EPS15	ENSCAFP00000023701	ENSCAFP00000005777	Dishevelled segment polarity protein 2.	Epidermal growth factor receptor pathway substrate 15.	0.505
EDEM1	ATF4	ENSCAFP00000008377	ENSCAFP00000001900	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	Activating transcription factor 4.	0.513
EDEM1	HERPUD1	ENSCAFP00000008377	ENSCAFP00000039708	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	Homocysteine inducible ER protein with ubiquitin like domain 1.	0.652
EEF2	PRNP	ENSCAFP00000028268	ENSCAFP00000009107	Eukaryotic translation elongation factor 2.	Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...]	0.513
EEF2	RANBP2	ENSCAFP00000028268	ENSCAFP00000062218	Eukaryotic translation elongation factor 2.	RAN binding protein 2.	0.556
EEF2	TRIM37	ENSCAFP00000028268	ENSCAFP00000025911	Eukaryotic translation elongation factor 2.	Tripartite motif containing 37.	0.481
EPS15	DVL2	ENSCAFP00000005777	ENSCAFP00000023701	Epidermal growth factor receptor pathway substrate 15.	Dishevelled segment polarity protein 2.	0.505
FBXO7	PRKN	ENSCAFP00000002556	ENSCAFP00000050441	F-box protein 7.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.601
FGR	TPR	ENSCAFP00000017792	ENSCAFP00000020227	Tyrosine-protein kinase.	Translocated promoter region, nuclear basket protein.	0.436
HDAC6	RANBP2	ENSCAFP00000049288	ENSCAFP00000062218	Histone deacetylase 6.	RAN binding protein 2.	0.428
HDAC6	SQSTM1	ENSCAFP00000049288	ENSCAFP00000065910	Histone deacetylase 6.	Sequestosome 1.	0.798
HERPUD1	ATF4	ENSCAFP00000039708	ENSCAFP00000001900	Homocysteine inducible ER protein with ubiquitin like domain 1.	Activating transcription factor 4.	0.523
HERPUD1	EDEM1	ENSCAFP00000039708	ENSCAFP00000008377	Homocysteine inducible ER protein with ubiquitin like domain 1.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.652