STRINGSTRING
IL4 IL4 HMOX1 HMOX1 C11H9orf72 C11H9orf72 KDR KDR SPTLC1 SPTLC1 SNX30 SNX30 NOD1 NOD1 SCOC SCOC WAC WAC PIP4K2C PIP4K2C PIP4K2A PIP4K2A OPTN OPTN RALB RALB STING1 STING1 DCN DCN RIPK2 RIPK2 NOD2 NOD2 RAB3GAP2 RAB3GAP2 IRF9 IRF9 BAG3 BAG3 SNX4 SNX4 SIRT1 SIRT1 FYCO1 FYCO1 HTT HTT VPS13D VPS13D CALCOCO2 CALCOCO2 MAPK3 MAPK3 LARP1 LARP1 SMCR8 SMCR8 ADRB2 ADRB2 F1PXS7_CANLF F1PXS7_CANLF WDR24 WDR24 SNX7 SNX7 SPTLC2 SPTLC2 BNIP3 BNIP3 RUFY4 RUFY4 LOC609558 LOC609558 TSC2 TSC2 J9P7B7_CANLF J9P7B7_CANLF ATG2A ATG2A SESN2 SESN2 PAFAH1B2 PAFAH1B2 PRAF2 PRAF2 MAPK3-2 MAPK3-2 TBK1 TBK1 SNX18 SNX18 ENSCAFP00000050634 ENSCAFP00000050634 SESN1 SESN1 ENSCAFP00000053367 ENSCAFP00000053367 LRSAM1 LRSAM1 TRIM13 TRIM13 PINK1 PINK1 RAB3GAP1 RAB3GAP1 SH3GLB1 SH3GLB1 SESN3 SESN3 AMBRA1 AMBRA1 WIPI1 WIPI1 SUPT5H SUPT5H HIF1A HIF1A PIP4K2B PIP4K2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (132 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
C11H9orf72Chromosome 11 C9orf72 homolog. (481 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (473 aa)
SNX30Sorting nexin family member 30. (446 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (964 aa)
SCOCShort coiled-coil protein. (122 aa)
WACWW domain-containing protein. (599 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (352 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (406 aa)
OPTNOptineurin. (608 aa)
RALBRAS like proto-oncogene B. (206 aa)
STING1Transmembrane protein 173. (375 aa)
DCNDecorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (360 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
NOD2Uncharacterized protein. (1013 aa)
RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2. (1540 aa)
IRF9Uncharacterized protein. (1136 aa)
BAG3BCL2 associated athanogene 3. (579 aa)
SNX4Sorting nexin 4. (433 aa)
SIRT1Sirtuin 1. (745 aa)
FYCO1FYVE and coiled-coil domain containing 1. (1459 aa)
HTTHuntingtin. (3130 aa)
VPS13DVacuolar protein sorting 13 homolog D. (4325 aa)
CALCOCO2Calcium binding and coiled-coil domain 2. (502 aa)
MAPK3Mitogen-activated protein kinase. (283 aa)
LARP1La ribonucleoprotein domain family member 1. (1069 aa)
SMCR8SMCR8-C9orf72 complex subunit. (935 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. (422 aa)
F1PXS7_CANLFProtein kinase domain-containing protein. (232 aa)
WDR24WD repeat domain 24. (735 aa)
SNX7Sorting nexin 7. (390 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (610 aa)
BNIP3BCL2 interacting protein 3. (354 aa)
RUFY4RUN and FYVE domain containing 4. (664 aa)
LOC609558Uncharacterized protein. (157 aa)
TSC2TSC complex subunit 2. (1783 aa)
J9P7B7_CANLFUncharacterized protein. (187 aa)
ATG2AAutophagy related 2A. (1936 aa)
SESN2Sestrin 2. (485 aa)
PAFAH1B2Platelet activating factor acetylhydrolase 1b catalytic subunit 2. (280 aa)
PRAF2WD repeat domain 45. (403 aa)
MAPK3-2Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
TBK1TANK binding kinase 1. (772 aa)
SNX18Sorting nexin 18. (849 aa)
ENSCAFP00000050634Uncharacterized protein. (501 aa)
SESN1Sestrin 1. (658 aa)
ENSCAFP00000053367Uncharacterized protein. (82 aa)
LRSAM1Leucine rich repeat and sterile alpha motif containing 1. (743 aa)
TRIM13Tripartite motif containing 13. (455 aa)
PINK1PTEN induced kinase 1. (558 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (988 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (369 aa)
SESN3Sestrin 3. (573 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1301 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (624 aa)
SUPT5HTranscription elongation factor SPT5. (1120 aa)
HIF1AUncharacterized protein. (823 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (441 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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