STRINGSTRING
ENSCAFP00000052454 ENSCAFP00000052454 RDH13 RDH13 PHGDH PHGDH CTBP2 CTBP2 PRXL2B PRXL2B PTGR1 PTGR1 ENSCAFP00000050742 ENSCAFP00000050742 ENSCAFP00000050595 ENSCAFP00000050595 LDHA LDHA BDH1 BDH1 LDHD LDHD MDH2 MDH2 ENSCAFP00000048786 ENSCAFP00000048786 HADH HADH ENSCAFP00000048006 ENSCAFP00000048006 ENSCAFP00000047270 ENSCAFP00000047270 UGDH UGDH LOC100856533 LOC100856533 J9NT18_CANLF J9NT18_CANLF DHRS1 DHRS1 J9P7R2_CANLF J9P7R2_CANLF ADH4 ADH4 J9NSR4_CANLF J9NSR4_CANLF J9P3N9_CANLF J9P3N9_CANLF D2HGDH D2HGDH J9P1U5_CANLF J9P1U5_CANLF HSD11B1 HSD11B1 J9NZM5_CANLF J9NZM5_CANLF J9NYH5_CANLF J9NYH5_CANLF SDR42E1 SDR42E1 MDH2-2 MDH2-2 SRD5A2 SRD5A2 J9NWV4_CANLF J9NWV4_CANLF AKR1E2 AKR1E2 J9NVM0_CANLF J9NVM0_CANLF J9NTB4_CANLF J9NTB4_CANLF J9JHZ0_CANLF J9JHZ0_CANLF LOC491379 LOC491379 LDHB LDHB F1PCN7_CANLF F1PCN7_CANLF MDH1 MDH1 LOC608055 LOC608055 ME1 ME1 HSD11B2 HSD11B2 HSD17B2 HSD17B2 G6PD G6PD IDH3G IDH3G NSDHL NSDHL RDH8 RDH8 DHRS11 DHRS11 DHRS7C DHRS7C KCNAB3 KCNAB3 PTGR2 PTGR2 PGD PGD HSD3B7 HSD3B7 CTBP1 CTBP1 RDH12 RDH12 HSD17B10 HSD17B10 DHRS7 DHRS7 AKR7L AKR7L HSD17B1 HSD17B1 LOC610164 LOC610164 L2HGDH L2HGDH IDH3A IDH3A SORD SORD IDH1 IDH1 MDH1B MDH1B EHHADH EHHADH DHRS9 DHRS9 IMPDH2 IMPDH2 LOC490617 LOC490617 DHRS2 DHRS2 DHRSX DHRSX BDH2 BDH2 LOC100856515 LOC100856515 ADH5 ADH5 HSD3B2 HSD3B2 HAO2 HAO2 CBR3 CBR3 UEVLD UEVLD GPD2 GPD2 SPR SPR KCNAB1 KCNAB1 F1P604_CANLF F1P604_CANLF LOC486100 LOC486100 CHDH CHDH GPD1 GPD1 HPGD HPGD CBR4 CBR4 ADHFE1 ADHFE1 CRYL1 CRYL1 SDR16C5 SDR16C5 HSD17B12 HSD17B12 IDH3B IDH3B FASN FASN DCXR DCXR HAO1 HAO1 AKR1C3 AKR1C3 ME3 ME3 HADHA HADHA HSD17B14 HSD17B14 DHDH DHDH HIBADH HIBADH GRHPR GRHPR F1PUW6_CANLF F1PUW6_CANLF IMPDH1 IMPDH1 AKR1B1 AKR1B1 ME2 ME2 RDH16 RDH16 SDR9C7 SDR9C7 HSD17B6 HSD17B6 RDH5 RDH5 ZADH2 ZADH2 LOC607806 LOC607806 LOC482711 LOC482711 DHRS3 DHRS3 HSD17B7 HSD17B7 ENSCAFP00000066231 ENSCAFP00000066231 KCNAB2 KCNAB2 HSD17B11 HSD17B11 IDH2 IDH2 TSTA3 TSTA3 ENSCAFP00000062047 ENSCAFP00000062047 ENSCAFP00000061965 ENSCAFP00000061965 HMGCR HMGCR ENSCAFP00000061079 ENSCAFP00000061079 RDH10 RDH10 LOC477365 LOC477365 ENSCAFP00000059599 ENSCAFP00000059599 ALDH3A2 ALDH3A2 ENSCAFP00000057673 ENSCAFP00000057673 ENSCAFP00000057449 ENSCAFP00000057449 SDR42E2 SDR42E2 LDHC LDHC AKR1A1 AKR1A1 KDSR KDSR ENSCAFP00000056268 ENSCAFP00000056268 GPD1L GPD1L ENSCAFP00000056057 ENSCAFP00000056057 HSD17B4 HSD17B4 ENSCAFP00000054689 ENSCAFP00000054689 H6PD H6PD ENSCAFP00000053230 ENSCAFP00000053230
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCAFP00000052454L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (279 aa)
RDH13Retinol dehydrogenase 13; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (388 aa)
PHGDHD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (646 aa)
CTBP2C-terminal binding protein 2. (914 aa)
PRXL2BPeroxiredoxin like 2B. (304 aa)
PTGR1Prostaglandin reductase 1. (357 aa)
ENSCAFP00000050742Ldh_1_N domain-containing protein. (104 aa)
ENSCAFP00000050595ADH_N domain-containing protein. (127 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (391 aa)
BDH13-hydroxybutyrate dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (323 aa)
LDHDLactate dehydrogenase D. (498 aa)
MDH2Malate dehydrogenase. (377 aa)
ENSCAFP00000048786Uncharacterized protein. (336 aa)
HADHHydroxyacyl-CoA dehydrogenase. (393 aa)
ENSCAFP00000048006Malate dehydrogenase. (322 aa)
ENSCAFP00000047270Ldh_1_N domain-containing protein. (170 aa)
UGDHUDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (501 aa)
LOC100856533PKS_ER domain-containing protein. (397 aa)
J9NT18_CANLFL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
DHRS1Dehydrogenase/reductase 1. (314 aa)
J9P7R2_CANLFAldo_ket_red domain-containing protein. (343 aa)
ADH4Alcohol dehydrogenase 4 (class II), pi polypeptide. (379 aa)
J9NSR4_CANLFLdh_1_N domain-containing protein. (183 aa)
J9P3N9_CANLFL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
D2HGDHD-2-hydroxyglutarate dehydrogenase. (387 aa)
J9P1U5_CANLFUncharacterized protein; Belongs to the LDH/MDH superfamily. (249 aa)
HSD11B1Hydroxysteroid 11-beta dehydrogenase 1. (337 aa)
J9NZM5_CANLFAldo_ket_red domain-containing protein. (95 aa)
J9NYH5_CANLFUncharacterized protein; Belongs to the LDH/MDH superfamily. (328 aa)
SDR42E1Short chain dehydrogenase/reductase family 42E, member 1; Belongs to the 3-beta-HSD family. (393 aa)
MDH2-2Malate dehydrogenase. (347 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
J9NWV4_CANLFUncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (365 aa)
AKR1E2Aldo-keto reductase family 1 member E2. (301 aa)
J9NVM0_CANLFL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (329 aa)
J9NTB4_CANLFUncharacterized protein; Belongs to the LDH/MDH superfamily. (281 aa)
J9JHZ0_CANLFLdh_1_N domain-containing protein. (194 aa)
LOC491379Aldo_ket_red domain-containing protein. (326 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
F1PCN7_CANLFIso_dh domain-containing protein. (366 aa)
MDH1Malate dehydrogenase. (334 aa)
LOC608055D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (572 aa)
ME1Malic enzyme. (563 aa)
HSD11B2Hydroxysteroid 11-beta dehydrogenase 2. (371 aa)
HSD17B2Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (444 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (624 aa)
IDH3GIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (392 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (361 aa)
RDH8Retinol dehydrogenase 8; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (331 aa)
DHRS11Dehydrogenase/reductase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (274 aa)
DHRS7CDehydrogenase/reductase 7C; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
KCNAB3Potassium voltage-gated channel subfamily A regulatory beta subunit 3. (546 aa)
PTGR2Uncharacterized protein. (524 aa)
PGD6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (480 aa)
HSD3B7Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; Belongs to the 3-beta-HSD family. (369 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (423 aa)
RDH12Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (308 aa)
HSD17B10Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa)
DHRS7Dehydrogenase/reductase 7; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (349 aa)
AKR7LAldo-keto reductase family 7 like (gene/pseudogene). (371 aa)
HSD17B1Hydroxysteroid 17-beta dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (310 aa)
LOC610164Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (459 aa)
L2HGDHL-2-hydroxyglutarate dehydrogenase. (674 aa)
IDH3AIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (366 aa)
SORDSorbitol dehydrogenase. (356 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
MDH1BMalate dehydrogenase 1B. (554 aa)
EHHADHEnoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (723 aa)
DHRS9Dehydrogenase/reductase 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (381 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
LOC490617Uncharacterized protein. (285 aa)
DHRS2Dehydrogenase/reductase 2. (293 aa)
DHRSXDehydrogenase/reductase X-linked. (306 aa)
BDH2Uncharacterized protein. (245 aa)
LOC100856515PKS_ER domain-containing protein. (375 aa)
ADH5S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (372 aa)
HSD3B23 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids (By similarity). (373 aa)
HAO2Hydroxyacid oxidase 2. (389 aa)
CBR3Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa)
UEVLDUEV and lactate/malate dehyrogenase domains. (512 aa)
GPD2Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (713 aa)
SPRSepiapterin reductase. (267 aa)
KCNAB1Potassium voltage-gated channel subfamily A member regulatory beta subunit 1. (424 aa)
F1P604_CANLFUncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (329 aa)
LOC486100FAD-binding PCMH-type domain-containing protein. (440 aa)
CHDHCholine dehydrogenase. (703 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
CBR4Carbonyl reductase 4. (316 aa)
ADHFE1Alcohol dehydrogenase iron containing 1. (467 aa)
CRYL1Crystallin lambda 1. (387 aa)
SDR16C5Short chain dehydrogenase/reductase family 16C member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
HSD17B12Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
IDH3BIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (385 aa)
FASNFatty acid synthase. (2478 aa)
DCXRDicarbonyl and L-xylulose reductase. (226 aa)
HAO1Hydroxyacid oxidase 1. (370 aa)
AKR1C3Aldo_ket_red domain-containing protein. (311 aa)
ME3Malic enzyme. (692 aa)
HADHAHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (762 aa)
HSD17B14Hydroxysteroid 17-beta dehydrogenase 14. (270 aa)
DHDHTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family. (335 aa)
HIBADH3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (336 aa)
GRHPRGlyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa)
F1PUW6_CANLFLdh_1_N domain-containing protein. (120 aa)
IMPDH1Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (542 aa)
AKR1B1Uncharacterized protein. (316 aa)
ME2Malic enzyme. (607 aa)
RDH16Retinol dehydrogenase 16; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
SDR9C7Short chain dehydrogenase/reductase family 9C member 7; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (313 aa)
HSD17B6Hydroxysteroid 17-beta dehydrogenase 6; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (331 aa)
RDH5Retinol dehydrogenase 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (318 aa)
ZADH2Zinc binding alcohol dehydrogenase domain containing 2. (377 aa)
LOC607806Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (326 aa)
LOC482711Aldo_ket_red domain-containing protein. (341 aa)
DHRS3Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (323 aa)
HSD17B7Hydroxysteroid 17-beta dehydrogenase 7. (338 aa)
ENSCAFP00000066231L-lactate dehydrogenase. (192 aa)
KCNAB2Potassium voltage-gated channel subfamily A regulatory beta subunit 2. (436 aa)
HSD17B11Hydroxysteroid 17-beta dehydrogenase 13; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (304 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (441 aa)
TSTA3Tissue specific transplantation antigen P35B. (398 aa)
ENSCAFP00000062047Ldh_1_N domain-containing protein. (114 aa)
ENSCAFP00000061965Aldo_ket_red domain-containing protein. (100 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (935 aa)
ENSCAFP00000061079Uncharacterized protein; Belongs to the LDH/MDH superfamily. (170 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (367 aa)
LOC477365Epimerase domain-containing protein. (442 aa)
ENSCAFP00000059599L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (357 aa)
ALDH3A2Multidrug and toxin extrusion protein; Belongs to the aldehyde dehydrogenase family. (1037 aa)
ENSCAFP00000057673L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (305 aa)
ENSCAFP00000057449Uncharacterized protein. (52 aa)
SDR42E2Epimerase domain-containing protein. (356 aa)
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
AKR1A1Aldo_ket_red domain-containing protein. (325 aa)
KDSR3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
ENSCAFP000000562682-Hacid_dh domain-containing protein. (102 aa)
GPD1LGlycerol-3-phosphate dehydrogenase [NAD(+)]. (485 aa)
ENSCAFP00000056057ADH_N domain-containing protein. (118 aa)
HSD17B4Hydroxysteroid 17-beta dehydrogenase 4. (775 aa)
ENSCAFP00000054689Uncharacterized protein. (58 aa)
H6PDHexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (824 aa)
ENSCAFP00000053230Ldh_1_N domain-containing protein. (226 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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