(52 nodes) Oxidoreductase activity, acting on peroxide as acceptor network (Canis lupus familiaris)

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experimentally determined

Predicted Interactions

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Your Input:
	ENSCAFP00000036430	annotation not available (152 aa)
	RTTN	Rotatin. (2225 aa)
	LTC4S	Leukotriene C4 synthase. (188 aa)
	TPO	Thyroid peroxidase; Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). Belongs to the peroxidase family. XPO subfamily. (944 aa)
	PXDN	Peroxidasin. (1359 aa)
	F1PFM4_CANLF	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (270 aa)
	MFSD11	Major facilitator superfamily domain containing 11. (449 aa)
	PXDNL	Peroxidasin like. (1468 aa)
	CAT	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells. (528 aa)
	GPX1	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (204 aa)
	GPX6	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (220 aa)
	PRDX3	Thioredoxin domain-containing protein. (278 aa)
	MGST1	Microsomal glutathione S-transferase 1. (166 aa)
	MGST3	Microsomal glutathione S-transferase 3. (152 aa)
	PRDX4	Peroxiredoxin 4. (276 aa)
	DUOX2	Dual oxidase 2. (1519 aa)
	DUOX1	Dual oxidase 1; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. (1551 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (604 aa)
	PRDX5	Redoxin domain-containing protein. (174 aa)
	GPX2	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (189 aa)
	LPO	Lactoperoxidase. (714 aa)
	MPO	Myeloperoxidase. (890 aa)
	BTBD6	BTB domain containing 6. (410 aa)
	PRDX2	Peroxiredoxin 2. (198 aa)
	CLIC6	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (247 aa)
	GPX5	Epididymal secretory glutathione peroxidase; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. (221 aa)
	F1PVK0_CANLF	DSBA domain-containing protein. (165 aa)
	GSTK1	Glutathione S-transferase kappa. (226 aa)
	J9NXF3_CANLF	Thioredoxin domain-containing protein. (269 aa)
	GPX8	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
	GPX3	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (225 aa)
	PTGES	Prostaglandin E synthase; Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). (153 aa)
	CLIC2	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (239 aa)
	J9P7L3_CANLF	Thioredoxin domain-containing protein. (199 aa)
	SESN2	Sestrin 2. (485 aa)
	J9PB41_CANLF	Thioredoxin domain-containing protein. (245 aa)
	PTGS1	Prostaglandin G/H synthase 1; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (By similarity). (724 aa)
	ENSCAFP00000047060	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (275 aa)
	ENSCAFP00000052207	Thioredoxin domain-containing protein. (135 aa)
	ENSCAFP00000052214	DSBA domain-containing protein. (175 aa)
	PRDX6	Peroxiredoxin 6. (236 aa)
	SESN1	Sestrin 1. (658 aa)
	EPX	Eosinophil peroxidase. (645 aa)
	ENSCAFP00000055837	Uncharacterized protein. (69 aa)
	ENSCAFP00000056474	1-cysPrx_C domain-containing protein. (96 aa)
	PRDX1	Thioredoxin domain-containing protein. (280 aa)
	SESN3	Sestrin 3. (573 aa)
	PARK7	Parkinsonism associated deglycase. (297 aa)
	ALOX5AP	Arachidonate 5-lipoxygenase activating protein. (255 aa)
	UPK3BL2	Uncharacterized protein. (317 aa)
	TXNRD1	Thioredoxin reductase 1; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (744 aa)
	TXNDC17	Thioredoxin domain containing 17. (131 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALOX5AP	LTC4S	ENSCAFP00000063629	ENSCAFP00000000503	Arachidonate 5-lipoxygenase activating protein.	Leukotriene C4 synthase.	0.754
CAT	ENSCAFP00000047060	ENSCAFP00000010324	ENSCAFP00000047060	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily.	0.400
CAT	ENSCAFP00000052207	ENSCAFP00000010324	ENSCAFP00000052207	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Thioredoxin domain-containing protein.	0.570
CAT	ENSCAFP00000055837	ENSCAFP00000010324	ENSCAFP00000055837	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Uncharacterized protein.	0.644
CAT	ENSCAFP00000056474	ENSCAFP00000010324	ENSCAFP00000056474	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	1-cysPrx_C domain-containing protein.	0.570
CAT	F1PFM4_CANLF	ENSCAFP00000010324	ENSCAFP00000005561	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.555
CAT	GPX1	ENSCAFP00000010324	ENSCAFP00000016889	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.443
CAT	GPX2	ENSCAFP00000010324	ENSCAFP00000023828	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.438
CAT	GPX3	ENSCAFP00000010324	ENSCAFP00000038899	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.438
CAT	GPX5	ENSCAFP00000010324	ENSCAFP00000034092	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Epididymal secretory glutathione peroxidase; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.	0.443
CAT	GPX6	ENSCAFP00000010324	ENSCAFP00000017566	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.438
CAT	GPX8	ENSCAFP00000010324	ENSCAFP00000037980	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.555
CAT	J9NXF3_CANLF	ENSCAFP00000010324	ENSCAFP00000037966	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Thioredoxin domain-containing protein.	0.570
CAT	J9P7L3_CANLF	ENSCAFP00000010324	ENSCAFP00000041651	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Thioredoxin domain-containing protein.	0.570
CAT	J9PB41_CANLF	ENSCAFP00000010324	ENSCAFP00000043019	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Thioredoxin domain-containing protein.	0.566
CAT	PARK7	ENSCAFP00000010324	ENSCAFP00000062561	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Parkinsonism associated deglycase.	0.702
CAT	PRDX1	ENSCAFP00000010324	ENSCAFP00000057261	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Thioredoxin domain-containing protein.	0.572
CAT	PRDX2	ENSCAFP00000010324	ENSCAFP00000031482	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Peroxiredoxin 2.	0.719
CAT	PRDX3	ENSCAFP00000010324	ENSCAFP00000017833	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Thioredoxin domain-containing protein.	0.570
CAT	PRDX4	ENSCAFP00000010324	ENSCAFP00000019709	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.	Peroxiredoxin 4.	0.570