STRINGSTRING
ZC3HAV1 ZC3HAV1 XYLT1 XYLT1 PARP8 PARP8 UPP1 UPP1 PARP11 PARP11 LACC1 LACC1 MROH6 MROH6 PARP9 PARP9 PARP14 PARP14 SIRT4 SIRT4 MTAP MTAP SIRT2 SIRT2 UPP1-2 UPP1-2 ART3 ART3 PARP2 PARP2 ENSCAFP00000063281 ENSCAFP00000063281 POGLUT3 POGLUT3 NAMPT NAMPT RXYLT1 RXYLT1 FAM162B FAM162B LARGE1 LARGE1 PPAT PPAT PARP12 PARP12 PRTFDC1 PRTFDC1 PNP PNP ART5 ART5 ART1 ART1 GXYLT2 GXYLT2 TNKS TNKS TNKS2 TNKS2 PARP4 PARP4 TIPARP TIPARP LARGE2 LARGE2 GXYLT1 GXYLT1 PARP3 PARP3 QTRT2 QTRT2 VWA5A VWA5A FAM162A FAM162A PARP15 PARP15 UMPS UMPS VWA5B2 VWA5B2 ART4 ART4 XXYLT1 XXYLT1 PARP1 PARP1 XYLT2 XYLT2 QTRT1 QTRT1 APRT APRT POGLUT2 POGLUT2 HPRT1 HPRT1 POGLUT1 POGLUT1 QPRT QPRT SIRT6 SIRT6 NAPRT NAPRT
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZC3HAV1Zinc finger CCCH-type containing, antiviral 1. (931 aa)
XYLT1Xylosyltransferase 1; Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D- xylose from UDP-D-xylose to specific serine residues of the core protein. Required for normal maturation of chondrocytes during bone development, normal onset of ossification and normal embryonic and postnatal skeleton development, especially of the long bones. (915 aa)
PARP8Poly [ADP-ribose] polymerase. (854 aa)
UPP1PNP_UDP_1 domain-containing protein. (440 aa)
PARP11Poly [ADP-ribose] polymerase. (400 aa)
LACC1Uncharacterized protein. (430 aa)
MROH6Maestro heat like repeat family member 6. (614 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (1030 aa)
PARP14Poly(ADP-ribose) polymerase family member 14. (1800 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (345 aa)
MTAPMethylthioadenosine phosphorylase. (356 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (334 aa)
UPP1-2PNP_UDP_1 domain-containing protein. (435 aa)
ART3NAD(P)(+)--arginine ADP-ribosyltransferase. (402 aa)
PARP2Poly [ADP-ribose] polymerase. (602 aa)
ENSCAFP00000063281Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
POGLUT3Protein O-glucosyltransferase 3. (519 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (534 aa)
RXYLT1Uncharacterized protein. (183 aa)
FAM162BFamily with sequence similarity 162 member B. (155 aa)
LARGE1LARGE xylosyl- and glucuronyltransferase 1. (800 aa)
PPATAmidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (517 aa)
PARP12Poly(ADP-ribose) polymerase family member 12. (703 aa)
PRTFDC1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (209 aa)
PNPPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
ART5NAD(P)(+)--arginine ADP-ribosyltransferase. (309 aa)
ART1NAD(P)(+)--arginine ADP-ribosyltransferase. (326 aa)
GXYLT2Glucoside xylosyltransferase 2. (442 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
TNKS2Poly [ADP-ribose] polymerase. (1316 aa)
PARP4Poly [ADP-ribose] polymerase. (1688 aa)
TIPARPTCDD inducible poly(ADP-ribose) polymerase. (719 aa)
LARGE2LARGE xylosyl- and glucuronyltransferase 2. (721 aa)
GXYLT1Glucoside xylosyltransferase 1. (392 aa)
PARP3Poly [ADP-ribose] polymerase. (531 aa)
QTRT2Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily. (433 aa)
VWA5AVon Willebrand factor A domain containing 5A. (809 aa)
FAM162AFamily with sequence similarity 162 member A. (155 aa)
PARP15Poly [ADP-ribose] polymerase. (686 aa)
UMPSUridine monophosphate synthetase. (480 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1227 aa)
ART4NAD(P)(+)--arginine ADP-ribosyltransferase. (328 aa)
XXYLT1Xyloside xylosyltransferase 1. (314 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (972 aa)
XYLT2Xylosyltransferase 2; Catalyzes the first step in the biosynthesis of chondroitin sulfate, heparan sulfate and dermatan sulfate proteoglycans, such as DCN (By similarity). Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein (By similarity). Belongs to the glycosyltransferase 14 family. XylT subfamily. (865 aa)
QTRT1Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (403 aa)
APRTAdenine phosphoribosyltransferase. (180 aa)
POGLUT2Protein O-glucosyltransferase 2. (518 aa)
HPRT1Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). (218 aa)
POGLUT1Protein O-glucosyltransferase 1. (392 aa)
QPRTNicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (299 aa)
SIRT6Sirtuin 6. (403 aa)
NAPRTNicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (534 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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