STRINGSTRING
PRPF6 PRPF6 TCF21 TCF21 ESR1 ESR1 DCAF13 DCAF13 MED30 MED30 EP300 EP300 BRD8 BRD8 HMGA1 HMGA1 FOXH1 FOXH1 CRY1 CRY1 NR1H2 NR1H2 THRAP3 THRAP3 MED25 MED25 CRX CRX NCOA1 NCOA1 MED17 MED17 LOC100856461 LOC100856461 TRIM24 TRIM24 MED4 MED4 SMARCD3 SMARCD3 ACTN4 ACTN4 TAF10 TAF10 TMF1 TMF1 NR1H4 NR1H4 RNF6 RNF6 KDM3A KDM3A NCOA6 NCOA6 CCDC62 CCDC62 ZNF366 ZNF366 NRIP1 NRIP1 CNOT1 CNOT1 PPID PPID NR1H3 NR1H3 MYOD1 MYOD1 VDR VDR MMS19 MMS19 GTF2H1 GTF2H1 NR4A2 NR4A2 CRY2 CRY2 DCAF1 DCAF1 NCOA3 NCOA3 NR1I2 NR1I2 DDX5 DDX5 ARID1A ARID1A PROX1 PROX1 SIRT1 SIRT1 PRAME PRAME STAT5B STAT5B PADI2 PADI2 DNAAF4 DNAAF4 SMARCE1 SMARCE1 SRARP SRARP PKN1 PKN1 MED1 MED1 NSD1 NSD1 TGFB1I1 TGFB1I1 MED12 MED12 SMAD3 SMAD3 PRKCB PRKCB TAF7L TAF7L MED13 MED13 BCAS3 BCAS3 MED16 MED16 LRIF1 LRIF1 GTF2B GTF2B RNF14 RNF14 TOB2 TOB2 TADA3 TADA3 C1D C1D TAF7 TAF7 NRBF2 NRBF2 TCF7L2 TCF7L2 SNW1 SNW1 LATS1 LATS1 STRN STRN J9PBG0_CANLF J9PBG0_CANLF ENSCAFP00000044371 ENSCAFP00000044371 ARID5A ARID5A ENSCAFP00000044673 ENSCAFP00000044673 TRIP4 TRIP4 MED4-2 MED4-2 DAXX DAXX LOC100856560 LOC100856560 TACC1 TACC1 NR0B1 NR0B1 PPARGC1A PPARGC1A ENSCAFP00000051035 ENSCAFP00000051035 CTBP2 CTBP2 PPARGC1B PPARGC1B DDX54 DDX54 KDM1A KDM1A ENSCAFP00000053603 ENSCAFP00000053603 NCOR1 NCOR1 BUD31 BUD31 ENSCAFP00000055276 ENSCAFP00000055276 FOXP1 FOXP1 LEF1 LEF1 NCOA7 NCOA7 YWHAH YWHAH SLC30A9 SLC30A9 ENSCAFP00000058309 ENSCAFP00000058309 RXRA RXRA ENSCAFP00000059928 ENSCAFP00000059928 TRIM68 TRIM68 TACC2 TACC2 MED24 MED24 NR4A3 NR4A3 ENSCAFP00000060937 ENSCAFP00000060937 PRMT2 PRMT2 WIPI1 WIPI1 PARK7 PARK7 NR4A1 NR4A1 RARG RARG ZBTB7A ZBTB7A ENSCAFP00000064778 ENSCAFP00000064778 HIF1A HIF1A GRIP1 GRIP1 NCOA2 NCOA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRPF6Pre-mRNA processing factor 6. (971 aa)
TCF21Transcription factor 21. (179 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (598 aa)
DCAF13DDB1 and CUL4 associated factor 13. (445 aa)
MED30Mediator complex subunit 30. (178 aa)
EP300E1A binding protein p300. (2308 aa)
BRD8Bromodomain containing 8. (1233 aa)
HMGA1High mobility group protein HMG-I/HMG-Y; HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions (By similarity); Belongs to the HMGA family. (106 aa)
FOXH1Forkhead box H1. (399 aa)
CRY1Cryptochrome circadian regulator 1. (587 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (455 aa)
THRAP3Thyroid hormone receptor associated protein 3. (958 aa)
MED25Mediator complex subunit 25. (529 aa)
CRXCone-rod homeobox protein; Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors (By similarity); Belongs to the paired homeobox family. (299 aa)
NCOA1Nuclear receptor coactivator. (1410 aa)
MED17Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (652 aa)
LOC100856461Bromo domain-containing protein. (653 aa)
TRIM24Tripartite motif containing 24. (1052 aa)
MED4Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (224 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (558 aa)
ACTN4Actinin alpha 4. (1163 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
TMF1TATA element modulatory factor 1. (1058 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (485 aa)
RNF6Ring finger protein 6. (683 aa)
KDM3ALysine demethylase 3A. (1322 aa)
NCOA6Nuclear receptor coactivator 6. (2060 aa)
CCDC62Coiled-coil domain containing 62. (662 aa)
ZNF366Zinc finger protein 366. (691 aa)
NRIP1Nuclear receptor interacting protein 1. (1178 aa)
CNOT1CCR4-NOT transcription complex subunit 1. (2376 aa)
PPIDPeptidylprolyl isomerase D. (370 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (447 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
VDRVitamin D receptor. (432 aa)
MMS19MMS19 homolog, cytosolic iron-sulfur assembly component. (1029 aa)
GTF2H1General transcription factor IIH subunit 1. (548 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
CRY2Cryptochrome circadian regulator 2. (593 aa)
DCAF1DDB1 and CUL4 associated factor 1. (1506 aa)
NCOA3Nuclear receptor coactivator. (1416 aa)
NR1I2Nuclear receptor subfamily 1 group I member 2. (471 aa)
DDX5Uncharacterized protein; Belongs to the DEAD box helicase family. (614 aa)
ARID1AAT-rich interaction domain 1A. (2284 aa)
PROX1Prospero homeobox 1. (737 aa)
SIRT1Sirtuin 1. (745 aa)
PRAMEPreferentially expressed antigen in melanoma. (512 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
PADI2Peptidyl arginine deiminase 2. (634 aa)
DNAAF4Dynein axonemal assembly factor 4. (420 aa)
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (376 aa)
SRARPSteroid receptor associated and regulated protein. (153 aa)
PKN1Protein kinase N1. (1145 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
NSD1Nuclear receptor binding SET domain protein 1. (2698 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (464 aa)
MED12Mediator complex subunit 12. (2141 aa)
SMAD3Mothers against decapentaplegic homolog. (611 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (767 aa)
TAF7LTATA-box binding protein associated factor 7 like. (504 aa)
MED13Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2157 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (950 aa)
MED16Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (397 aa)
LRIF1Ligand dependent nuclear receptor interacting factor 1. (757 aa)
GTF2BGeneral transcription factor IIB. (316 aa)
RNF14RBR-type E3 ubiquitin transferase. (474 aa)
TOB2Transducer of ERBB2, 2. (336 aa)
TADA3Transcriptional adaptor 3. (432 aa)
C1DC1D nuclear receptor corepressor. (141 aa)
TAF7TATA-box binding protein associated factor 7. (349 aa)
NRBF2Nuclear receptor binding factor 2. (288 aa)
TCF7L2Transcription factor 7 like 2. (565 aa)
SNW1SNW domain containing 1. (536 aa)
LATS1Large tumor suppressor kinase 1. (1127 aa)
STRNStriatin. (679 aa)
J9PBG0_CANLFUncharacterized protein. (109 aa)
ENSCAFP00000044371Uncharacterized protein. (187 aa)
ARID5AAT-rich interaction domain 5A. (881 aa)
ENSCAFP00000044673Uncharacterized protein. (109 aa)
TRIP4Thyroid hormone receptor interactor 4. (584 aa)
MED4-2Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (224 aa)
DAXXDeath domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 throu [...] (735 aa)
LOC100856560RING-type domain-containing protein. (207 aa)
TACC1Transforming acidic coiled-coil containing protein 1. (1002 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (487 aa)
PPARGC1APPARG coactivator 1 alpha. (891 aa)
ENSCAFP00000051035Uncharacterized protein. (340 aa)
CTBP2C-terminal binding protein 2. (914 aa)
PPARGC1BPPARG coactivator 1 beta. (1028 aa)
DDX54ATP-dependent RNA helicase DDX54; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (866 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (877 aa)
ENSCAFP00000053603Uncharacterized protein. (96 aa)
NCOR1Nuclear receptor corepressor 1. (2542 aa)
BUD31Uncharacterized protein. (144 aa)
ENSCAFP00000055276Uncharacterized protein. (363 aa)
FOXP1Forkhead box P1. (693 aa)
LEF1Lymphoid enhancer binding factor 1. (481 aa)
NCOA7Nuclear receptor coactivator 7. (1224 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (266 aa)
SLC30A9Solute carrier family 30 member 9. (609 aa)
ENSCAFP00000058309Uncharacterized protein. (61 aa)
RXRARetinoid X receptor alpha. (556 aa)
ENSCAFP00000059928HMG box domain-containing protein. (331 aa)
TRIM68Tripartite motif containing 68. (485 aa)
TACC2Transforming acidic coiled-coil containing protein 2. (2955 aa)
MED24Mediator complex subunit 24. (1026 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (579 aa)
ENSCAFP00000060937HMG box domain-containing protein. (119 aa)
PRMT2Protein arginine methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (535 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (624 aa)
PARK7Parkinsonism associated deglycase. (297 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). (606 aa)
RARGRetinoic acid receptor gamma. (628 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (714 aa)
ENSCAFP00000064778Uncharacterized protein. (179 aa)
HIF1AUncharacterized protein. (823 aa)
GRIP1Glutamate receptor interacting protein 1. (1203 aa)
NCOA2Nuclear receptor coactivator 2. (1568 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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