STRINGSTRING
METTL14 METTL14 BANK1 BANK1 EIF2S1 EIF2S1 NANOS2 NANOS2 MEX3D MEX3D YTHDF2 YTHDF2 TSC1 TSC1 CIRBP CIRBP PLEKHN1 PLEKHN1 FMR1 FMR1 SHMT1 SHMT1 SHFL SHFL ILF3 ILF3 LARP1 LARP1 CNOT8 CNOT8 TOB1 TOB1 IGF2BP1 IGF2BP1 TARDBP TARDBP NANOS3 NANOS3 ZFP36L1 ZFP36L1 GRB7 GRB7 SRP9 SRP9 CNOT9 CNOT9 UPF1 UPF1 IGFBP5 IGFBP5 RC3H1 RC3H1 EXOSC7 EXOSC7 DDX6 DDX6 GIGYF2 GIGYF2 PUM1 PUM1 LRRC27 LRRC27 CAPRIN2 CAPRIN2 DCPS DCPS EIF4EBP2 EIF4EBP2 PCIF1 PCIF1 BTG2 BTG2 CNOT6L CNOT6L DHX36 DHX36 DCP1A DCP1A CNOT1 CNOT1 ENC1 ENC1 EIF6 EIF6 PDE12 PDE12 PATL1 PATL1 LSM14A LSM14A CAPRIN1 CAPRIN1 CNOT7 CNOT7 EIF4EBP1 EIF4EBP1 LSM1 LSM1 EIF2AK2 EIF2AK2 DND1 DND1 PURA PURA EIF4A3 EIF4A3 ZFP36 ZFP36 RPS3 RPS3 EXOSC9 EXOSC9 PUS7 PUS7 NOCT NOCT RPL13A RPL13A AGO4 AGO4 AGO1 AGO1 AGO3 AGO3 TIA1 TIA1 SYNCRIP SYNCRIP PNPT1 PNPT1 MALSU1 MALSU1 YBX1 YBX1 EXOSC3 EXOSC3 CNOT11 CNOT11 IREB2 IREB2 DAPK1 DAPK1 MRPL13 MRPL13 PNLDC1 PNLDC1 CNOT6 CNOT6 SHMT2 SHMT2 PAN2 PAN2 TPR TPR PATL2 PATL2 YTHDF1 YTHDF1 EIF4ENIF1 EIF4ENIF1 PAIP2B PAIP2B PARN PARN RC3H2 RC3H2 CPEB4 CPEB4 EPRS1 EPRS1 RNF139 RNF139 FXR1 FXR1 ENSCAFP00000063024 ENSCAFP00000063024 ENSCAFP00000060413 ENSCAFP00000060413 CPEB1 CPEB1 LOC479011 LOC479011 ENSCAFP00000057429 ENSCAFP00000057429 DDX3X DDX3X CNOT2 CNOT2 EXOSC8 EXOSC8 CNOT3 CNOT3 DIS3L2 DIS3L2 FXR2 FXR2 EIF4E EIF4E ROCK1 ROCK1 SAMD4B SAMD4B TNRC6A TNRC6A C8orf88 C8orf88 ENSCAFP00000048491 ENSCAFP00000048491 CPEB2 CPEB2 ENSCAFP00000047314 ENSCAFP00000047314 TNRC6B TNRC6B CPEB3 CPEB3 ENSCAFP00000045619 ENSCAFP00000045619 ZC3H12A ZC3H12A ENSCAFP00000044783 ENSCAFP00000044783 AGO2 AGO2 PAN3 PAN3 PAIP2 PAIP2 J9P9A0_CANLF J9P9A0_CANLF SESN2 SESN2 EXOSC5 EXOSC5 YTHDF3 YTHDF3 EXOSC2 EXOSC2 ZFP36L2 ZFP36L2 DCP2 DCP2 TNRC6C TNRC6C RIDA RIDA NANOS1 NANOS1 SAMD4A SAMD4A TRIM71 TRIM71 CNOT10 CNOT10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
METTL14Methyltransferase like 14; Belongs to the MT-A70-like family. (456 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (787 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
NANOS2Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (138 aa)
MEX3DMex-3 RNA binding family member D. (671 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (580 aa)
TSC1TSC complex subunit 1. (1169 aa)
CIRBPCold inducible RNA binding protein. (172 aa)
PLEKHN1Pleckstrin homology domain containing N1. (618 aa)
FMR1Fragile X mental retardation 1. (615 aa)
SHMT1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
SHFLShiftless antiviral inhibitor of ribosomal frameshifting. (286 aa)
ILF3Interleukin enhancer binding factor 3. (900 aa)
LARP1La ribonucleoprotein domain family member 1. (1069 aa)
CNOT8CCR4-NOT transcription complex subunit 8. (292 aa)
TOB1Transducer of ERBB2, 1. (492 aa)
IGF2BP1Insulin like growth factor 2 mRNA binding protein 1. (577 aa)
TARDBPTAR DNA binding protein. (607 aa)
NANOS3Nanos C2HC-type zinc finger 3; Belongs to the nanos family. (224 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
GRB7Growth factor receptor bound protein 7. (553 aa)
SRP9Signal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding. (86 aa)
CNOT9CCR4-NOT transcription complex subunit 9. (299 aa)
UPF1UPF1 RNA helicase and ATPase. (1130 aa)
IGFBP5Insulin like growth factor binding protein 5. (271 aa)
RC3H1Ring finger and CCCH-type domains 1. (1132 aa)
EXOSC7Exosome component 7. (291 aa)
DDX6DEAD-box helicase 6; Belongs to the DEAD box helicase family. (483 aa)
GIGYF2GRB10 interacting GYF protein 2. (1318 aa)
PUM1Pumilio RNA binding family member 1. (1224 aa)
LRRC27Leucine rich repeat containing 27. (533 aa)
CAPRIN2Caprin family member 2. (1144 aa)
DCPSDecapping enzyme, scavenger. (443 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E binding protein 2. (120 aa)
PCIF1PDX1 C-terminal inhibiting factor 1. (702 aa)
BTG2BTG anti-proliferation factor 2. (243 aa)
CNOT6LCCR4-NOT transcription complex subunit 6 like. (558 aa)
DHX36DEAH-box helicase 36. (1122 aa)
DCP1ADecapping mRNA 1A. (699 aa)
CNOT1CCR4-NOT transcription complex subunit 1. (2376 aa)
ENC1Ectodermal-neural cortex 1. (589 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
PDE12Phosphodiesterase 12. (616 aa)
PATL1PAT1 homolog 1, processing body mRNA decay factor. (771 aa)
LSM14ALSM14A mRNA processing body assembly factor. (448 aa)
CAPRIN1Uncharacterized protein. (717 aa)
CNOT7CCR4-NOT transcription complex subunit 7. (285 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
EIF2AK2Eukaryotic translation initiation factor 2-alpha kinase 2. (532 aa)
DND1DND microRNA-mediated repression inhibitor 1. (353 aa)
PURAPurine rich element binding protein A. (469 aa)
EIF4A3Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. (411 aa)
ZFP36ZFP36 ring finger protein. (335 aa)
RPS340S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8- dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] (243 aa)
EXOSC9Exosome component 9. (423 aa)
PUS7Pseudouridine synthase 7. (695 aa)
NOCTNocturnin. (452 aa)
RPL13A60S ribosomal protein L13a; Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppres [...] (203 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (854 aa)
AGO1Argonaute RISC component 1; Belongs to the argonaute family. (1037 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
TIA1TIA1 cytotoxic granule associated RNA binding protein. (386 aa)
SYNCRIPSynaptotagmin binding cytoplasmic RNA interacting protein. (562 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (763 aa)
MALSU1Mitochondrial assembly of ribosomal large subunit 1. (236 aa)
YBX1Y-box binding protein 1. (324 aa)
EXOSC3Exosome component 3. (275 aa)
CNOT11CCR4-NOT transcription complex subunit 11. (517 aa)
IREB2Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. (964 aa)
DAPK1Death associated protein kinase 1. (1430 aa)
MRPL13Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family. (178 aa)
PNLDC1PARN like, ribonuclease domain containing 1. (531 aa)
CNOT6CCR4-NOT transcription complex subunit 6. (592 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (549 aa)
PAN2PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1202 aa)
TPRTranslocated promoter region, nuclear basket protein. (2361 aa)
PATL2PAT1 homolog 2. (532 aa)
YTHDF1YTH N6-methyladenosine RNA binding protein 1. (558 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E nuclear import factor 1. (994 aa)
PAIP2BPoly(A) binding protein interacting protein 2B. (124 aa)
PARNPoly(A)-specific ribonuclease. (665 aa)
RC3H2Ring finger and CCCH-type domains 2. (1191 aa)
CPEB4Cytoplasmic polyadenylation element binding protein 4. (742 aa)
EPRS1Glutamyl-prolyl-tRNA synthetase. (1516 aa)
RNF139Ring finger protein 139. (958 aa)
FXR1FMR1 autosomal homolog 1. (648 aa)
ENSCAFP00000063024CSD_1 domain-containing protein. (205 aa)
ENSCAFP00000060413Uncharacterized protein. (88 aa)
CPEB1RRM domain-containing protein. (802 aa)
LOC479011CSD domain-containing protein. (296 aa)
ENSCAFP00000057429Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (168 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (663 aa)
CNOT2CCR4-NOT transcription complex subunit 2. (594 aa)
EXOSC8Exosome component 8. (448 aa)
CNOT3CCR4-NOT transcription complex subunit 3. (785 aa)
DIS3L2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (963 aa)
FXR2FMR1 autosomal homolog 2. (690 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (246 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1381 aa)
SAMD4BSterile alpha motif domain containing 4B. (806 aa)
TNRC6ATrinucleotide repeat containing adaptor 6A. (1983 aa)
C8orf88Chromosome 8 open reading frame 88. (149 aa)
ENSCAFP00000048491RRM domain-containing protein. (292 aa)
CPEB2Cytoplasmic polyadenylation element binding protein 2. (712 aa)
ENSCAFP00000047314Uncharacterized protein. (153 aa)
TNRC6BTrinucleotide repeat containing adaptor 6B. (2268 aa)
CPEB3Cytoplasmic polyadenylation element binding protein 3. (715 aa)
ENSCAFP00000045619Uncharacterized protein. (58 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (605 aa)
ENSCAFP00000044783CSP domain-containing protein. (298 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (843 aa)
PAN3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (955 aa)
PAIP2Poly(A) binding protein interacting protein 2. (156 aa)
J9P9A0_CANLFCSD_1 domain-containing protein. (372 aa)
SESN2Sestrin 2. (485 aa)
EXOSC5Exosome component 5. (235 aa)
YTHDF3YTH N6-methyladenosine RNA binding protein 3. (588 aa)
EXOSC2Exosome component 2. (293 aa)
ZFP36L2ZFP36 ring finger protein like 2. (456 aa)
DCP2Decapping mRNA 2. (422 aa)
TNRC6CTrinucleotide repeat containing adaptor 6C. (1968 aa)
RIDAReactive intermediate imine deaminase A homolog. (336 aa)
NANOS1Nanos-type domain-containing protein; Belongs to the nanos family. (193 aa)
SAMD4ASterile alpha motif domain containing 4A. (718 aa)
TRIM71Tripartite motif containing 71. (868 aa)
CNOT10CCR4-NOT transcription complex subunit 10. (803 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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