STRINGSTRING
RYR2 RYR2 TMOD2 TMOD2 CACNA1S CACNA1S FXR1 FXR1 SVIL SVIL TRIM54 TRIM54 ENSCAFP00000065595 ENSCAFP00000065595 MYL2 MYL2 CFL2 CFL2 PYROXD1 PYROXD1 KLHL41 KLHL41 BAG3 BAG3 ABCC9 ABCC9 CAPN9 CAPN9 XIRP2 XIRP2 MYO18B MYO18B GGPS1 GGPS1 ADPRH ADPRH ACTN2 ACTN2 MYOZ2 MYOZ2 TNNI1 TNNI1 CAPN3 CAPN3 PPP3CA PPP3CA LOC483676 LOC483676 ENSCAFP00000062374 ENSCAFP00000062374 PDLIM2 PDLIM2 ACTA2 ACTA2 NEXN NEXN MYBPC1 MYBPC1 ENSCAFP00000061338 ENSCAFP00000061338 PDLIM5 PDLIM5 TEKT1 TEKT1 PSEN2 PSEN2 MYL12B MYL12B SCN3B SCN3B ADPRHL1 ADPRHL1 ENSCAFP00000057483 ENSCAFP00000057483 ENSCAFP00000057453 ENSCAFP00000057453 SYNM SYNM MYL3 MYL3 ENSCAFP00000057067 ENSCAFP00000057067 PPP1R12A PPP1R12A TNNT3 TNNT3 MYZAP MYZAP ANKRD1 ANKRD1 TNNT1 TNNT1 PDLIM3 PDLIM3 MYH6 MYH6 CHORDC1 CHORDC1 DES DES MYH15 MYH15 PPP1R12B PPP1R12B MYOT MYOT NEBL NEBL CSRP1 CSRP1 PDE4B PDE4B SYNE2 SYNE2 CASQ2 CASQ2 C18H7orf57 C18H7orf57 PALLD PALLD ENSCAFP00000049249 ENSCAFP00000049249 ACTG2 ACTG2 ACTN1 ACTN1 ATP2B4 ATP2B4 ENSCAFP00000047500 ENSCAFP00000047500 MYOM2 MYOM2 TNNC1 TNNC1 PPP3CB PPP3CB TCAP TCAP SMN SMN RTN2 RTN2 IGSF22 IGSF22 SIMC1 SIMC1 SYNC SYNC J9P960_CANLF J9P960_CANLF SRI SRI TNNT2 TNNT2 CASQ1 CASQ1 ANKRD23 ANKRD23 MYL7 MYL7 LOC100856485 LOC100856485 FBP2 FBP2 FHL5 FHL5 C28H10orf71 C28H10orf71 KAT2B KAT2B PDLIM1 PDLIM1 PDE4DIP PDE4DIP NRAP NRAP J9NV76_CANLF J9NV76_CANLF KCNJ8 KCNJ8 SCO1 SCO1 STUB1 STUB1 TWF1 TWF1 LRRC10B LRRC10B FBXO32 FBXO32 ANKRD40 ANKRD40 ILK ILK TRIM32 TRIM32 E2R2S9_CANLF E2R2S9_CANLF LRRC39 LRRC39 MYBPHL MYBPHL FLNA FLNA MTM1 MTM1 MTMR12 MTMR12 MYOM1 MYOM1 UNC45B UNC45B SYNPO SYNPO MYOZ3 MYOZ3 ASB2 ASB2 MYH4 MYH4 MYH3 MYH3 MYH2 MYH2 MYH1 MYH1 MYH8 MYH8 MYH13 MYH13 ITGB1BP2 ITGB1BP2 FBXL22 FBXL22 PSEN1 PSEN1 PDLIM7 PDLIM7 LDB3 LDB3 AKAP4 AKAP4 JUP JUP VCL VCL MYH16 MYH16 SYNPO2L SYNPO2L MYOZ1 MYOZ1 MYOM2-2 MYOM2-2 SLC4A1 SLC4A1 CRYAB CRYAB MYL4 MYL4 MYPN MYPN HSPB1 HSPB1 GLRX3 GLRX3 SMPX SMPX MYOM3 MYOM3 ACTN3 ACTN3 TMOD4 TMOD4 SYNPO2 SYNPO2 LMAN1 LMAN1 MYL1 MYL1 LRRC10 LRRC10 SCO2 SCO2 ABRA ABRA PDLIM4 PDLIM4 PRICKLE4 PRICKLE4 LMOD2 LMOD2 PGM5 PGM5 FHL2 FHL2 TMOD1 TMOD1 CAVIN4 CAVIN4 DNAAF3 DNAAF3 TNNI3 TNNI3 FHL3 FHL3 BMP10 BMP10 HRC HRC FKBP1B FKBP1B SCN5A SCN5A KLHL40 KLHL40 RYR1 RYR1 LMOD3 LMOD3 KCTD6 KCTD6 LOC102151511 LOC102151511 SMTNL1 SMTNL1 MYH7B MYH7B ACTA1 ACTA1 MYL9 MYL9 MYBPC3 MYBPC3 MYOD1 MYOD1 HOMER1 HOMER1 CSRP3 CSRP3 TLR9 TLR9 TNNI2 TNNI2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RYR2Ryanodine receptor 2. (4903 aa)
TMOD2Tropomodulin 2. (356 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2002 aa)
FXR1FMR1 autosomal homolog 1. (648 aa)
SVILSupervillin. (2246 aa)
TRIM54Tripartite motif containing 54. (429 aa)
ENSCAFP00000065595Ig-like domain-containing protein. (160 aa)
MYL2Myosin light chain 2. (175 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
PYROXD1Pyridine nucleotide-disulphide oxidoreductase domain 1. (483 aa)
KLHL41Kelch like family member 41. (606 aa)
BAG3BCL2 associated athanogene 3. (579 aa)
ABCC9ATP binding cassette subfamily C member 9. (1549 aa)
CAPN9Calpain 9; Belongs to the peptidase C2 family. (692 aa)
XIRP2Xin actin binding repeat containing 2. (3291 aa)
MYO18BMyosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2557 aa)
GGPS1Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family. (300 aa)
ADPRHADP-ribosylarginine hydrolase. (362 aa)
ACTN2Actinin alpha 2. (894 aa)
MYOZ2Myozenin 2. (264 aa)
TNNI1Troponin I1, slow skeletal type. (270 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (821 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
LOC483676Uncharacterized protein; Belongs to the actin family. (380 aa)
ENSCAFP00000062374IF rod domain-containing protein; Belongs to the intermediate filament family. (439 aa)
PDLIM2PDZ and LIM domain 2. (687 aa)
ACTA2Actin alpha 2, smooth muscle. (421 aa)
NEXNNexilin F-actin binding protein. (881 aa)
MYBPC1Myosin binding protein C, slow type. (1203 aa)
ENSCAFP00000061338Uncharacterized protein. (163 aa)
PDLIM5PDZ and LIM domain 5. (626 aa)
TEKT1Tektin-1. (504 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (526 aa)
MYL12BUncharacterized protein. (259 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (292 aa)
ADPRHL1Uncharacterized protein. (352 aa)
ENSCAFP00000057483Uncharacterized protein. (167 aa)
ENSCAFP00000057453PDZ domain-containing protein. (221 aa)
SYNMSynemin; Belongs to the intermediate filament family. (1280 aa)
MYL3Myosin light chain 3. (308 aa)
ENSCAFP00000057067Myotubularin phosphatase domain-containing protein. (544 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1084 aa)
TNNT3Troponin T3, fast skeletal type. (340 aa)
MYZAPUncharacterized protein. (765 aa)
ANKRD1Ankyrin repeat domain 1. (340 aa)
TNNT1Troponin T1, slow skeletal type. (328 aa)
PDLIM3PDZ and LIM domain 3. (405 aa)
MYH6Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1894 aa)
CHORDC1Cysteine and histidine rich domain containing 1. (510 aa)
DESDesmin; Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-ancho [...] (644 aa)
MYH15Myosin heavy chain 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1807 aa)
PPP1R12BProtein phosphatase 1 regulatory subunit. (1059 aa)
MYOTMyotilin. (804 aa)
NEBLNebulette. (1017 aa)
CSRP1Cysteine and glycine rich protein 1. (201 aa)
PDE4BPhosphodiesterase. (737 aa)
SYNE2Spectrin repeat containing nuclear envelope protein 2. (6903 aa)
CASQ2Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. (554 aa)
C18H7orf57Chromosome 18 C7orf57 homolog. (432 aa)
PALLDPalladin, cytoskeletal associated protein. (1178 aa)
ENSCAFP00000049249Uncharacterized protein. (234 aa)
ACTG2Deoxyguanosine kinase. (521 aa)
ACTN1Actinin alpha 1. (956 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1206 aa)
ENSCAFP00000047500Uncharacterized protein. (178 aa)
MYOM2Uncharacterized protein. (1022 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (303 aa)
PPP3CBSerine/threonine-protein phosphatase. (534 aa)
TCAPTitin-cap. (210 aa)
SMNSurvival motor neuron protein; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the ch [...] (323 aa)
RTN2Reticulon. (499 aa)
IGSF22Immunoglobulin superfamily member 22. (1342 aa)
SIMC1SUMO interacting motifs containing 1. (941 aa)
SYNCSyncoilin, intermediate filament protein; Belongs to the intermediate filament family. (472 aa)
J9P960_CANLFUncharacterized protein. (181 aa)
SRISorcin. (348 aa)
TNNT2Troponin T2, cardiac type. (296 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (591 aa)
ANKRD23Ankyrin repeat domain 39. (433 aa)
MYL7Uncharacterized protein. (203 aa)
LOC100856485Uncharacterized protein. (147 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (360 aa)
FHL5Four and a half LIM domains 5. (284 aa)
C28H10orf71Chromosome 28 C10orf71 homolog. (1423 aa)
KAT2BLysine acetyltransferase 2B. (738 aa)
PDLIM1PDZ and LIM domain 1. (317 aa)
PDE4DIPPhosphodiesterase 4D interacting protein. (2632 aa)
NRAPNebulin related anchoring protein. (1728 aa)
J9NV76_CANLFUncharacterized protein. (172 aa)
KCNJ8Potassium voltage-gated channel subfamily J member 8. (424 aa)
SCO1SCO cytochrome c oxidase assembly protein 1. (304 aa)
STUB1STIP1 homology and U-box containing protein 1. (306 aa)
TWF1Twinfilin actin binding protein 1. (376 aa)
LRRC10BLeucine rich repeat containing 10B. (292 aa)
FBXO32F-box protein 32. (355 aa)
ANKRD40Ankyrin repeat domain 40. (342 aa)
ILKIntegrin linked kinase. (452 aa)
TRIM32Tripartite motif containing 32. (655 aa)
E2R2S9_CANLFPDZ domain-containing protein. (257 aa)
LRRC39Leucine rich repeat containing 39. (335 aa)
MYBPHLMyosin binding protein H like. (406 aa)
FLNAFilamin A. (2646 aa)
MTM1Myotubularin 1. (654 aa)
MTMR12Myotubularin related protein 12. (732 aa)
MYOM1Myomesin 1. (1724 aa)
UNC45BUnc-45 myosin chaperone B. (945 aa)
SYNPOSynaptopodin. (1017 aa)
MYOZ3Myozenin 3. (254 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (630 aa)
MYH4Myosin-4; Muscle contraction. (1939 aa)
MYH3Myosin heavy chain 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1940 aa)
MYH2Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity). (1940 aa)
MYH1Myosin-1; Muscle contraction. (1953 aa)
MYH8Myosin-8; Muscle contraction. (1940 aa)
MYH13Myosin-13; Fast twitching myosin mediating the high-velocity and low- tension contractions of specific striated muscles; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
ITGB1BP2Integrin subunit beta 1 binding protein 2. (347 aa)
FBXL22Uncharacterized protein. (223 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (466 aa)
PDLIM7PDZ domain-containing protein. (269 aa)
LDB3LIM domain binding 3. (780 aa)
AKAP4A-kinase anchoring protein 4. (856 aa)
JUPUncharacterized protein. (744 aa)
VCLVinculin. (1147 aa)
MYH16Myosin-16; May play a role in masticatory muscles contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1945 aa)
SYNPO2LSynaptopodin 2 like. (1074 aa)
MYOZ1Calsarcin 2. (297 aa)
MYOM2-2Ig-like domain-containing protein. (623 aa)
SLC4A1Anion exchange protein. (930 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
MYL4Myosin light chain 4. (299 aa)
MYPNMyopalladin. (1322 aa)
HSPB1Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. (206 aa)
GLRX3Glutaredoxin 3. (333 aa)
SMPXSmall muscle protein X-linked. (88 aa)
MYOM3Myomesin 3. (1449 aa)
ACTN3Actinin alpha 3. (1061 aa)
TMOD4Tropomodulin 4. (345 aa)
SYNPO2Synaptopodin 2. (1262 aa)
LMAN1Lectin, mannose binding 1. (518 aa)
MYL1Myosin light chain 1. (232 aa)
LRRC10Leucine rich repeat containing 10. (279 aa)
SCO2SCO cytochrome c oxidase assembly protein 2. (390 aa)
ABRAActin binding Rho activating protein. (380 aa)
PDLIM4PDZ and LIM domain 4. (331 aa)
PRICKLE4Uncharacterized protein. (515 aa)
LMOD2Leiomodin 2. (158 aa)
PGM5Phosphoglucomutase 5; Belongs to the phosphohexose mutase family. (480 aa)
FHL2Four and a half LIM domains 2. (279 aa)
TMOD1Tropomodulin 1. (359 aa)
CAVIN4Caveolae associated protein 4. (361 aa)
DNAAF3Dynein axonemal assembly factor 3. (504 aa)
TNNI3Troponin I, cardiac muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (211 aa)
FHL3Four and a half LIM domains 3. (290 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
HRCHistidine rich calcium binding protein. (763 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2013 aa)
KLHL40Kelch like family member 40. (625 aa)
RYR1Ryanodine receptor 1. (5038 aa)
LMOD3Leiomodin 3. (620 aa)
KCTD6Potassium channel tetramerization domain containing 6. (237 aa)
LOC102151511Uncharacterized protein. (1176 aa)
SMTNL1Smoothelin like 1. (498 aa)
MYH7BMyosin heavy chain 7B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1844 aa)
ACTA1Actin alpha 1, skeletal muscle. (377 aa)
MYL9Myosin light chain 9. (172 aa)
MYBPC3Myosin binding protein C, cardiac. (1293 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
HOMER1Homer scaffold protein 1. (354 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
TLR9Twinfilin actin binding protein 2. (349 aa)
TNNI2Troponin I2, fast skeletal type. (182 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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