STRINGSTRING
ENSCAFP00000057483 ENSCAFP00000057483 PDLIM4 PDLIM4 ITGB1BP2 ITGB1BP2 ASB2 ASB2 MYOZ3 MYOZ3 SYNPO SYNPO UNC45B UNC45B FLNA FLNA E2R2S9_CANLF E2R2S9_CANLF FBXO32 FBXO32 STUB1 STUB1 NRAP NRAP PDLIM1 PDLIM1 C28H10orf71 C28H10orf71 PSEN1 PSEN1 PDLIM7 PDLIM7 LDB3 LDB3 AKAP4 AKAP4 JUP JUP SYNPO2L SYNPO2L MYOZ1 MYOZ1 SLC4A1 SLC4A1 CRYAB CRYAB MYPN MYPN HSPB1 HSPB1 GLRX3 GLRX3 ACTN3 ACTN3 PPP1R12A PPP1R12A FBXL22 FBXL22 MYOZ2 MYOZ2 SYNPO2 SYNPO2 BAG3 BAG3 CAPN9 CAPN9 XIRP2 XIRP2 MYO18B MYO18B GGPS1 GGPS1 ACTN2 ACTN2 CAPN3 CAPN3 PPP3CA PPP3CA RYR2 RYR2 CSRP3 CSRP3 HOMER1 HOMER1 LOC102151511 LOC102151511 RYR1 RYR1 SCN5A SCN5A FKBP1B FKBP1B HRC HRC BMP10 BMP10 FHL3 FHL3 CAVIN4 CAVIN4 FHL2 FHL2 PGM5 PGM5 PRICKLE4 PRICKLE4 FHL5 FHL5 FBP2 FBP2 CASQ1 CASQ1 SRI SRI SYNC SYNC IGSF22 IGSF22 RTN2 RTN2 SMN SMN TCAP TCAP PPP3CB PPP3CB ATP2B4 ATP2B4 ACTN1 ACTN1 ENSCAFP00000049249 ENSCAFP00000049249 PALLD PALLD C18H7orf57 C18H7orf57 CASQ2 CASQ2 SYNE2 SYNE2 PDE4B PDE4B CSRP1 CSRP1 NEBL NEBL MYOT MYOT PPP1R12B PPP1R12B DES DES CHORDC1 CHORDC1 MYH6 MYH6 PDLIM3 PDLIM3 CFL2 CFL2 ENSCAFP00000065595 ENSCAFP00000065595 TRIM54 TRIM54 ENSCAFP00000062374 ENSCAFP00000062374 PDLIM2 PDLIM2 NEXN NEXN PDLIM5 PDLIM5 PSEN2 PSEN2 SCN3B SCN3B ENSCAFP00000057453 ENSCAFP00000057453
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCAFP00000057483Uncharacterized protein. (167 aa)
PDLIM4PDZ and LIM domain 4. (331 aa)
ITGB1BP2Integrin subunit beta 1 binding protein 2. (347 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (630 aa)
MYOZ3Myozenin 3. (254 aa)
SYNPOSynaptopodin. (1017 aa)
UNC45BUnc-45 myosin chaperone B. (945 aa)
FLNAFilamin A. (2646 aa)
E2R2S9_CANLFPDZ domain-containing protein. (257 aa)
FBXO32F-box protein 32. (355 aa)
STUB1STIP1 homology and U-box containing protein 1. (306 aa)
NRAPNebulin related anchoring protein. (1728 aa)
PDLIM1PDZ and LIM domain 1. (317 aa)
C28H10orf71Chromosome 28 C10orf71 homolog. (1423 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (466 aa)
PDLIM7PDZ domain-containing protein. (269 aa)
LDB3LIM domain binding 3. (780 aa)
AKAP4A-kinase anchoring protein 4. (856 aa)
JUPUncharacterized protein. (744 aa)
SYNPO2LSynaptopodin 2 like. (1074 aa)
MYOZ1Calsarcin 2. (297 aa)
SLC4A1Anion exchange protein. (930 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
MYPNMyopalladin. (1322 aa)
HSPB1Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. (206 aa)
GLRX3Glutaredoxin 3. (333 aa)
ACTN3Actinin alpha 3. (1061 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1084 aa)
FBXL22Uncharacterized protein. (223 aa)
MYOZ2Myozenin 2. (264 aa)
SYNPO2Synaptopodin 2. (1262 aa)
BAG3BCL2 associated athanogene 3. (579 aa)
CAPN9Calpain 9; Belongs to the peptidase C2 family. (692 aa)
XIRP2Xin actin binding repeat containing 2. (3291 aa)
MYO18BMyosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2557 aa)
GGPS1Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family. (300 aa)
ACTN2Actinin alpha 2. (894 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (821 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
RYR2Ryanodine receptor 2. (4903 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
HOMER1Homer scaffold protein 1. (354 aa)
LOC102151511Uncharacterized protein. (1176 aa)
RYR1Ryanodine receptor 1. (5038 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2013 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
HRCHistidine rich calcium binding protein. (763 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
FHL3Four and a half LIM domains 3. (290 aa)
CAVIN4Caveolae associated protein 4. (361 aa)
FHL2Four and a half LIM domains 2. (279 aa)
PGM5Phosphoglucomutase 5; Belongs to the phosphohexose mutase family. (480 aa)
PRICKLE4Uncharacterized protein. (515 aa)
FHL5Four and a half LIM domains 5. (284 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (360 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (591 aa)
SRISorcin. (348 aa)
SYNCSyncoilin, intermediate filament protein; Belongs to the intermediate filament family. (472 aa)
IGSF22Immunoglobulin superfamily member 22. (1342 aa)
RTN2Reticulon. (499 aa)
SMNSurvival motor neuron protein; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the ch [...] (323 aa)
TCAPTitin-cap. (210 aa)
PPP3CBSerine/threonine-protein phosphatase. (534 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1206 aa)
ACTN1Actinin alpha 1. (956 aa)
ENSCAFP00000049249Uncharacterized protein. (234 aa)
PALLDPalladin, cytoskeletal associated protein. (1178 aa)
C18H7orf57Chromosome 18 C7orf57 homolog. (432 aa)
CASQ2Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. (554 aa)
SYNE2Spectrin repeat containing nuclear envelope protein 2. (6903 aa)
PDE4BPhosphodiesterase. (737 aa)
CSRP1Cysteine and glycine rich protein 1. (201 aa)
NEBLNebulette. (1017 aa)
MYOTMyotilin. (804 aa)
PPP1R12BProtein phosphatase 1 regulatory subunit. (1059 aa)
DESDesmin; Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-ancho [...] (644 aa)
CHORDC1Cysteine and histidine rich domain containing 1. (510 aa)
MYH6Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1894 aa)
PDLIM3PDZ and LIM domain 3. (405 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
ENSCAFP00000065595Ig-like domain-containing protein. (160 aa)
TRIM54Tripartite motif containing 54. (429 aa)
ENSCAFP00000062374IF rod domain-containing protein; Belongs to the intermediate filament family. (439 aa)
PDLIM2PDZ and LIM domain 2. (687 aa)
NEXNNexilin F-actin binding protein. (881 aa)
PDLIM5PDZ and LIM domain 5. (626 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (526 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (292 aa)
ENSCAFP00000057453PDZ domain-containing protein. (221 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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